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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BARX1
Z-value: 1.03
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Transcription factors associated with BARX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARX1 | hg38_v1_chr9_-_93955347_93955362 | 0.11 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_151025343 Show fit | 43.58 |
ENST00000521632.1
|
glutathione peroxidase 3 |
|
| chr5_+_141382702 Show fit | 16.40 |
ENST00000617050.1
ENST00000518325.2 |
protocadherin gamma subfamily A, 7 |
|
| chr9_-_14300231 Show fit | 16.11 |
ENST00000636735.1
|
nuclear factor I B |
|
| chr13_-_44474296 Show fit | 15.93 |
ENST00000611198.4
|
TSC22 domain family member 1 |
|
| chr14_+_55129242 Show fit | 11.46 |
ENST00000254301.14
ENST00000554715.1 |
galectin 3 |
|
| chr1_-_94925759 Show fit | 10.17 |
ENST00000415017.1
ENST00000545882.5 |
calponin 3 |
|
| chr11_-_125592448 Show fit | 10.14 |
ENST00000648911.1
|
fasciculation and elongation protein zeta 1 |
|
| chr1_-_230745574 Show fit | 10.07 |
ENST00000681269.1
|
angiotensinogen |
|
| chrX_+_136205982 Show fit | 9.85 |
ENST00000628568.1
|
four and a half LIM domains 1 |
|
| chr4_+_41538143 Show fit | 9.78 |
ENST00000503057.6
ENST00000511496.5 |
LIM and calponin homology domains 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 76.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 14.5 | 43.6 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.3 | 33.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.5 | 16.1 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.5 | 14.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.1 | 14.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.7 | 13.9 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 1.1 | 13.2 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.5 | 11.7 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.0 | 11.6 | GO:0006936 | muscle contraction(GO:0006936) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 53.8 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 0.1 | 40.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.9 | 18.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.8 | 16.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 15.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.1 | 14.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 13.1 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 12.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 11.4 | GO:0044439 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.1 | 10.4 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 74.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.8 | 45.2 | GO:0008430 | selenium binding(GO:0008430) |
| 0.3 | 26.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 17.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.7 | 15.7 | GO:0031005 | filamin binding(GO:0031005) |
| 0.3 | 15.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.9 | 13.9 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 13.9 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 13.7 | GO:0003779 | actin binding(GO:0003779) |
| 0.4 | 12.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 15.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 12.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 11.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 11.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 10.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 10.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.5 | 9.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 8.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 7.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.5 | 16.1 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 16.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.5 | 15.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.5 | 14.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 11.5 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.5 | 10.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 8.7 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 8.2 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.5 | 8.1 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |