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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BCL6B
Z-value: 0.65
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Transcription factors associated with BCL6B
Network of associatons between targets according to the STRING database.
First level regulatory network of BCL6B
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_149377637 Show fit | 16.14 |
ENST00000305366.8
|
transmembrane 4 L six family member 1 |
|
| chr2_-_215393126 Show fit | 12.59 |
ENST00000456923.5
|
fibronectin 1 |
|
| chr20_+_11892493 Show fit | 11.84 |
ENST00000422390.5
ENST00000618918.4 |
BTB domain containing 3 |
|
| chr9_-_115118145 Show fit | 11.25 |
ENST00000350763.9
|
tenascin C |
|
| chr9_-_115118198 Show fit | 11.12 |
ENST00000534839.1
ENST00000535648.5 |
tenascin C |
|
| chr2_-_175005357 Show fit | 9.05 |
ENST00000409156.7
ENST00000444573.2 ENST00000409900.9 |
chimerin 1 |
|
| chr2_-_55010348 Show fit | 8.29 |
ENST00000394609.6
|
reticulon 4 |
|
| chr12_+_103930600 Show fit | 8.00 |
ENST00000680316.1
ENST00000679861.1 |
heat shock protein 90 beta family member 1 |
|
| chr1_-_108192818 Show fit | 7.37 |
ENST00000370041.4
|
solute carrier family 25 member 24 |
|
| chr9_-_110256466 Show fit | 6.97 |
ENST00000374515.9
ENST00000374517.6 |
thioredoxin |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 22.4 | GO:0060739 | mesenchymal-epithelial cell signaling involved in prostate gland development(GO:0060739) |
| 0.9 | 14.8 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.0 | 14.7 | GO:0006936 | muscle contraction(GO:0006936) |
| 4.2 | 12.6 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 2.5 | 12.6 | GO:0044821 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.1 | 11.3 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 1.2 | 10.4 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.2 | 9.0 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.8 | 8.3 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 1.1 | 7.4 | GO:0015866 | ADP transport(GO:0015866) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 22.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 22.4 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 1.0 | 14.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.9 | 13.3 | GO:0030478 | actin cap(GO:0030478) |
| 1.0 | 12.6 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 1.0 | 11.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 11.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 10.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.3 | 8.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.3 | 6.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 22.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.0 | 17.4 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 1.0 | 13.5 | GO:0046790 | virion binding(GO:0046790) |
| 0.5 | 13.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.6 | 12.6 | GO:0043495 | protein anchor(GO:0043495) |
| 0.2 | 12.6 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.3 | 10.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 9.0 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 1.1 | 7.4 | GO:0005347 | adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217) |
| 1.2 | 7.0 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 37.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 14.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 10.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.2 | 10.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 10.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 9.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 7.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 7.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 4.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 4.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 18.7 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.3 | 17.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.6 | 15.3 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 1.1 | 14.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 7.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.4 | 7.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 6.8 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 6.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 5.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |