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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BHLHE22_BHLHA15_BHLHE23
Z-value: 0.56
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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23
Network of associatons between targets according to the STRING database.
First level regulatory network of BHLHE22_BHLHA15_BHLHE23
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_121660892 Show fit | 23.83 |
ENST00000428394.6
ENST00000314583.8 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chrX_+_129779930 Show fit | 13.99 |
ENST00000356892.4
|
SAM and SH3 domain containing 3 |
|
| chr10_+_5094405 Show fit | 13.22 |
ENST00000380554.5
|
aldo-keto reductase family 1 member C3 |
|
| chr5_-_111976925 Show fit | 8.31 |
ENST00000395634.7
|
neuronal regeneration related protein |
|
| chr19_-_54364983 Show fit | 8.22 |
ENST00000434277.6
|
leukocyte associated immunoglobulin like receptor 1 |
|
| chr14_-_106025628 Show fit | 8.04 |
ENST00000631943.1
|
immunoglobulin heavy variable 7-4-1 |
|
| chr11_+_17295322 Show fit | 7.22 |
ENST00000458064.6
ENST00000622082.4 |
nucleobindin 2 |
|
| chr11_+_65638085 Show fit | 7.04 |
ENST00000534313.6
ENST00000533361.1 ENST00000526137.1 |
signal-induced proliferation-associated 1 |
|
| chr5_-_170297746 Show fit | 6.23 |
ENST00000046794.10
|
lymphocyte cytosolic protein 2 |
|
| chr1_+_244051275 Show fit | 5.47 |
ENST00000358704.4
|
zinc finger and BTB domain containing 18 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 23.8 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 16.5 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.6 | 14.0 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 4.4 | 13.2 | GO:0006714 | sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224) |
| 0.2 | 8.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 1.8 | 7.0 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.1 | 6.7 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.3 | 5.6 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 1.8 | 5.3 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.3 | 5.0 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 8.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 7.9 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 6.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 1.2 | 6.2 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.1 | 5.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 5.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 5.3 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.1 | 5.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 3.9 | GO:0031901 | early endosome membrane(GO:0031901) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 4.4 | 13.2 | GO:0045550 | geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787) |
| 0.0 | 9.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 9.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 6.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.5 | 5.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 5.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.9 | 4.6 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.1 | 4.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 4.0 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 37.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 9.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 5.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 5.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.6 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.2 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.2 | 7.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 5.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 5.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 4.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 3.2 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 2.7 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 2.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 2.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.0 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |