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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BHLHE22_BHLHA15_BHLHE23
Z-value: 0.56
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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
BHLHE22
|
ENSG00000180828.3 | BHLHE22 |
|
BHLHA15
|
ENSG00000180535.4 | BHLHA15 |
|
BHLHE23
|
ENSG00000125533.6 | BHLHE23 |
Activity profile of BHLHE22_BHLHA15_BHLHE23 motif
Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of BHLHE22_BHLHA15_BHLHE23
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 13.2 | GO:0006714 | sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224) |
| 1.8 | 5.3 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 1.8 | 7.0 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 1.4 | 23.8 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.8 | 4.0 | GO:0048022 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670) |
| 0.6 | 14.0 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 0.5 | 4.6 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.5 | 2.0 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.5 | 1.8 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 0.5 | 4.6 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.4 | 0.8 | GO:0097325 | melanocyte proliferation(GO:0097325) |
| 0.4 | 3.2 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.3 | 1.4 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.3 | 1.0 | GO:0001812 | positive regulation of type I hypersensitivity(GO:0001812) |
| 0.3 | 5.0 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.3 | 2.0 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.3 | 1.3 | GO:1901143 | insulin catabolic process(GO:1901143) |
| 0.3 | 3.8 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.3 | 1.6 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.3 | 5.6 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.3 | 3.9 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.3 | 1.8 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.2 | 2.1 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.2 | 0.6 | GO:0060279 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.2 | 1.4 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.2 | 2.0 | GO:0001865 | NK T cell differentiation(GO:0001865) |
| 0.2 | 8.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.6 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.1 | 2.7 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 1.4 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.1 | 4.3 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.1 | 1.3 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 2.0 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 1.3 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 0.4 | GO:1904075 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.1 | 0.8 | GO:0009048 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.1 | 0.9 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.1 | 0.2 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.1 | 6.7 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.1 | 0.6 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.1 | 0.5 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.1 | 1.1 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 1.7 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.0 | 1.2 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 1.3 | GO:1902751 | positive regulation of cell cycle G2/M phase transition(GO:1902751) |
| 0.0 | 1.6 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.0 | 16.5 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.0 | 0.2 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.0 | 4.9 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 0.2 | GO:0010759 | positive regulation of macrophage chemotaxis(GO:0010759) negative regulation of interleukin-12 production(GO:0032695) |
| 0.0 | 0.1 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.0 | 0.5 | GO:0034243 | regulation of transcription elongation from RNA polymerase II promoter(GO:0034243) |
| 0.0 | 1.0 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 1.3 | GO:1902036 | regulation of hematopoietic stem cell differentiation(GO:1902036) |
| 0.0 | 0.3 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.2 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.6 | 1.8 | GO:0097636 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.5 | 1.4 | GO:0036194 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.2 | 2.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 2.0 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.2 | 0.6 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.2 | 3.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 1.7 | GO:0044754 | autolysosome(GO:0044754) |
| 0.2 | 1.3 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.2 | 1.1 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 1.6 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 5.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 5.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 2.0 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 0.4 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.1 | 1.3 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.1 | 0.2 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 0.1 | 0.3 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 8.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 26.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 0.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 7.9 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 1.6 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.0 | 0.4 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.0 | 5.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 6.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 0.2 | GO:1990745 | EARP complex(GO:1990745) |
| 0.0 | 2.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 3.9 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 1.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 3.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.3 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 5.3 | GO:0030133 | transport vesicle(GO:0030133) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 13.2 | GO:0045550 | geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787) |
| 0.9 | 4.6 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.5 | 5.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.4 | 1.3 | GO:0031626 | beta-endorphin binding(GO:0031626) |
| 0.4 | 1.8 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.3 | 2.0 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.3 | 0.6 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 1.8 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.2 | 4.0 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
| 0.2 | 1.4 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.2 | 3.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 1.0 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) IgE binding(GO:0019863) |
| 0.1 | 23.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 1.2 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.1 | 0.3 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.1 | 4.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 2.0 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 1.6 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 2.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 0.6 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 2.1 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 1.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 1.0 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 3.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 9.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 9.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 5.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 1.3 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.8 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.6 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.0 | 0.2 | GO:0004738 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.0 | 2.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.6 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.2 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.0 | 6.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 1.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.2 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 1.7 | GO:0008135 | translation factor activity, RNA binding(GO:0008135) |
| 0.0 | 0.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.4 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 1.2 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 1.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.1 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.7 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 37.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 5.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 2.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 9.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 5.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.6 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.4 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 0.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 2.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 8.2 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.2 | 7.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 2.7 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 1.3 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 0.9 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.1 | 3.2 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 2.0 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 0.6 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 5.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 2.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 5.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.1 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 1.2 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 1.2 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.6 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 0.6 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.7 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.6 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 2.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |