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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for BHLHE40

Z-value: 0.97

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Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.5 BHLHE40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE40hg38_v1_chr3_+_4979428_4979495-0.018.4e-01Click!

Activity profile of BHLHE40 motif

Sorted Z-values of BHLHE40 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE40

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_54135203 23.17 ENST00000260102.9
ENST00000519831.5
MRPL15
mitochondrial ribosomal protein L15
chr1_-_43172504 23.03 ENST00000431635.6
EBNA1BP2
EBNA1 binding protein 2
chrX_+_23667461 21.41 ENST00000379341.9
ENST00000379331.3
PRDX4
peroxiredoxin 4
chr1_-_43172244 20.47 ENST00000236051.3
EBNA1BP2
EBNA1 binding protein 2
chr4_+_56435730 18.51 ENST00000514888.5
ENST00000264221.6
ENST00000505164.5
PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr4_+_56436131 17.85 ENST00000399688.7
PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr2_-_27323006 17.60 ENST00000402310.5
ENST00000405983.5
ENST00000403262.6
MPV17
mitochondrial inner membrane protein MPV17
chr11_+_60842095 17.30 ENST00000227520.10
CCDC86
coiled-coil domain containing 86
chr2_-_10447771 15.54 ENST00000405333.5
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr2_-_46916020 15.12 ENST00000409800.5
ENST00000409218.5
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr2_-_27323072 14.95 ENST00000428910.5
ENST00000402722.5
ENST00000380044.6
ENST00000399052.8
ENST00000405076.5
MPV17
mitochondrial inner membrane protein MPV17
chr8_-_98117110 14.84 ENST00000520507.5
RIDA
reactive intermediate imine deaminase A homolog
chr2_-_10448318 13.84 ENST00000234111.9
ODC1
ornithine decarboxylase 1
chr17_-_63773534 13.21 ENST00000403162.7
ENST00000582252.1
ENST00000225726.10
CCDC47
coiled-coil domain containing 47
chr6_-_5260883 13.20 ENST00000330636.9
LYRM4
LYR motif containing 4
chr2_-_46915745 12.99 ENST00000649435.1
ENST00000409105.5
ENST00000319466.9
ENST00000409973.5
ENST00000409913.5
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr12_+_93467506 12.20 ENST00000549982.6
ENST00000552217.6
ENST00000393128.8
ENST00000547098.5
MRPL42
mitochondrial ribosomal protein L42
chr1_-_85708382 11.24 ENST00000370574.4
ENST00000431532.6
ZNHIT6
zinc finger HIT-type containing 6
chr5_-_72320217 11.14 ENST00000508863.6
ENST00000522095.1
ENST00000513900.5
ENST00000515404.5
ENST00000261413.10
ENST00000457646.8
MRPS27
mitochondrial ribosomal protein S27
chr5_+_36151989 11.08 ENST00000274254.9
SKP2
S-phase kinase associated protein 2
chr1_-_193105373 10.63 ENST00000367439.8
GLRX2
glutaredoxin 2
chr17_-_54968637 10.49 ENST00000299335.8
COX11
cytochrome c oxidase copper chaperone COX11
chr8_-_98117155 10.41 ENST00000254878.8
ENST00000521560.1
RIDA
reactive intermediate imine deaminase A homolog
chr6_+_13615322 10.18 ENST00000451315.7
NOL7
nucleolar protein 7
chr10_-_95656643 10.12 ENST00000371221.3
ENST00000371224.7
ALDH18A1
aldehyde dehydrogenase 18 family member A1
chr6_-_5260730 9.75 ENST00000464010.5
ENST00000500576.4
ENST00000468929.5
ENST00000480566.5
LYRM4
LYR motif containing 4
chr21_-_25735570 9.62 ENST00000400090.7
ENST00000400087.7
ENST00000400093.3
ATP5PF
ATP synthase peripheral stalk subunit F6
chr19_-_18323065 9.47 ENST00000252816.10
ENST00000593829.6
LSM4
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
chr1_-_200620729 9.21 ENST00000367350.5
KIF14
kinesin family member 14
chr20_+_23350755 8.95 ENST00000254998.3
NXT1
nuclear transport factor 2 like export factor 1
chr19_-_18323100 8.72 ENST00000594828.7
LSM4
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
chrX_-_16869840 8.35 ENST00000380084.8
RBBP7
RB binding protein 7, chromatin remodeling factor
chr22_-_43015133 8.30 ENST00000453643.5
ENST00000263246.8
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr21_-_25735026 7.89 ENST00000400099.5
ENST00000457143.6
ATP5PF
ATP synthase peripheral stalk subunit F6
chr17_+_38752731 7.86 ENST00000619426.5
ENST00000610434.4
PSMB3
proteasome 20S subunit beta 3
chr2_+_206765578 7.82 ENST00000403094.3
ENST00000402774.8
FASTKD2
FAST kinase domains 2
chrX_-_47659128 7.82 ENST00000333119.7
ENST00000335890.3
UXT
ubiquitously expressed prefoldin like chaperone
chr11_+_64234569 7.78 ENST00000309422.7
ENST00000426086.3
VEGFB
vascular endothelial growth factor B
chr16_-_56668034 7.55 ENST00000569500.5
ENST00000379811.4
ENST00000444837.6
MT1G
metallothionein 1G
chr8_+_32548303 7.52 ENST00000650967.1
NRG1
neuregulin 1
chr19_-_55140922 7.40 ENST00000589745.5
TNNT1
troponin T1, slow skeletal type
chr19_-_5719849 7.28 ENST00000590729.5
LONP1
lon peptidase 1, mitochondrial
chr7_+_116672187 7.11 ENST00000318493.11
ENST00000397752.8
MET
MET proto-oncogene, receptor tyrosine kinase
chr22_-_30591850 7.07 ENST00000335214.8
ENST00000406208.7
ENST00000402284.7
ENST00000354694.12
PES1
pescadillo ribosomal biogenesis factor 1
chr9_+_706841 6.99 ENST00000382293.7
KANK1
KN motif and ankyrin repeat domains 1
chr16_+_29900345 6.74 ENST00000563177.5
ENST00000483405.5
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr19_-_5720159 6.72 ENST00000593119.5
LONP1
lon peptidase 1, mitochondrial
chr5_+_36152077 6.70 ENST00000546211.6
ENST00000620197.5
ENST00000678270.1
ENST00000679015.1
ENST00000678580.1
ENST00000274255.11
ENST00000508514.5
SKP2
S-phase kinase associated protein 2
chr18_+_58045642 6.65 ENST00000676223.1
ENST00000675147.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr11_+_6603708 6.65 ENST00000532063.5
ILK
integrin linked kinase
chr18_+_58045683 6.60 ENST00000592846.5
ENST00000675801.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr14_+_77458032 6.58 ENST00000535854.6
ENST00000555517.1
ENST00000216479.8
AHSA1
activator of HSP90 ATPase activity 1
chr11_+_6603740 6.45 ENST00000537806.5
ENST00000420936.6
ENST00000299421.9
ENST00000528995.5
ENST00000396751.6
ILK
integrin linked kinase
chr1_+_45550783 6.25 ENST00000621846.4
ENST00000434299.5
ENST00000351829.9
AKR1A1
aldo-keto reductase family 1 member A1
chr8_+_32548210 6.21 ENST00000523079.5
ENST00000650919.1
NRG1
neuregulin 1
chr2_+_73926826 6.18 ENST00000629438.2
ENST00000348222.3
ENST00000264093.9
DGUOK
deoxyguanosine kinase
chr8_+_108443601 6.18 ENST00000524143.5
ENST00000220853.8
EMC2
ER membrane protein complex subunit 2
chr19_-_5720131 5.56 ENST00000587365.1
ENST00000360614.8
ENST00000585374.5
LONP1
lon peptidase 1, mitochondrial
chr21_+_33230375 5.15 ENST00000447980.1
IFNAR2
interferon alpha and beta receptor subunit 2
chr11_-_61792581 4.99 ENST00000537328.6
TMEM258
transmembrane protein 258
chr16_+_29900474 4.95 ENST00000308748.10
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr1_+_117929720 4.76 ENST00000369441.7
ENST00000349139.6
WDR3
WD repeat domain 3
chr2_-_135985568 4.67 ENST00000264161.9
DARS1
aspartyl-tRNA synthetase 1
chr1_+_218346235 4.46 ENST00000366929.4
TGFB2
transforming growth factor beta 2
chr6_-_111606260 4.32 ENST00000340026.10
TRAF3IP2
TRAF3 interacting protein 2
chr1_+_7771263 4.29 ENST00000054666.11
VAMP3
vesicle associated membrane protein 3
chr4_+_88007624 4.25 ENST00000237596.7
PKD2
polycystin 2, transient receptor potential cation channel
chr19_+_45406630 4.15 ENST00000309424.8
POLR1G
RNA polymerase I subunit G
chr10_+_99732211 3.99 ENST00000370476.10
ENST00000370472.4
CUTC
cutC copper transporter
chr1_+_43979877 3.93 ENST00000356836.10
ENST00000309519.8
B4GALT2
beta-1,4-galactosyltransferase 2
chr6_+_44247866 3.66 ENST00000371554.2
HSP90AB1
heat shock protein 90 alpha family class B member 1
chr12_-_24949026 3.58 ENST00000539780.5
ENST00000546285.1
ENST00000342945.9
ENST00000261192.12
BCAT1
branched chain amino acid transaminase 1
chr4_-_56435581 3.57 ENST00000264220.6
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr17_-_3668557 3.57 ENST00000225525.4
TAX1BP3
Tax1 binding protein 3
chr8_-_108443409 3.56 ENST00000678023.1
ENST00000679198.1
ENST00000678881.1
ENST00000677084.1
ENST00000676663.1
ENST00000677614.1
ENST00000677040.1
ENST00000676487.1
ENST00000677409.1
ENST00000678797.1
ENST00000678334.1
EIF3E
eukaryotic translation initiation factor 3 subunit E
chr5_+_90474879 3.44 ENST00000504930.5
ENST00000514483.5
POLR3G
RNA polymerase III subunit G
chr17_+_36949285 3.34 ENST00000681062.1
ENST00000679881.1
ENST00000680782.1
AATF
apoptosis antagonizing transcription factor
chr5_+_90474848 3.31 ENST00000651687.1
POLR3G
RNA polymerase III subunit G
chr18_+_58196736 3.16 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr1_+_231241195 3.08 ENST00000436239.5
ENST00000366647.9
ENST00000416000.1
GNPAT
glyceronephosphate O-acyltransferase
chr12_-_6568256 3.00 ENST00000382421.7
ENST00000545200.5
ENST00000399466.6
ENST00000322166.10
ENST00000536124.5
ENST00000540228.1
ENST00000542867.5
ENST00000545492.5
ENST00000545915.5
ENST00000620535.4
ENST00000617555.4
NOP2
NOP2 nucleolar protein
chr22_-_30557586 2.62 ENST00000338911.6
ENST00000453479.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr17_+_74203582 2.57 ENST00000439590.6
ENST00000311111.11
ENST00000584577.5
ENST00000534490.5
ENST00000528433.2
ENST00000533498.1
RPL38
ribosomal protein L38
chr4_-_176792913 2.54 ENST00000618562.2
VEGFC
vascular endothelial growth factor C
chr15_+_58431985 2.41 ENST00000433326.2
ENST00000299022.10
LIPC
lipase C, hepatic type
chr17_+_50719565 2.37 ENST00000625349.2
ENST00000393227.6
ENST00000240304.5
ENST00000505658.6
ENST00000505619.5
ENST00000510984.5
LUC7L3
LUC7 like 3 pre-mRNA splicing factor
chr17_-_76737321 2.35 ENST00000359995.10
ENST00000508921.7
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
SRSF2
serine and arginine rich splicing factor 2
chr9_+_127802858 2.35 ENST00000393706.6
ENST00000630236.2
ENST00000373247.7
ENST00000373228.5
FPGS
folylpolyglutamate synthase
chr8_+_98117285 1.98 ENST00000401707.7
ENST00000522319.5
POP1
POP1 homolog, ribonuclease P/MRP subunit
chrX_+_129906146 1.92 ENST00000394422.8
UTP14A
UTP14A small subunit processome component
chr2_-_111884117 1.83 ENST00000341068.8
ANAPC1
anaphase promoting complex subunit 1
chr6_+_5260992 1.67 ENST00000324331.10
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr10_-_103917657 1.61 ENST00000369764.1
STN1
STN1 subunit of CST complex
chr12_-_47904986 1.60 ENST00000549336.6
VDR
vitamin D receptor
chrX_+_129906118 1.55 ENST00000425117.6
UTP14A
UTP14A small subunit processome component
chr11_-_65859282 1.53 ENST00000526975.1
ENST00000531413.5
ENST00000525451.6
CFL1
cofilin 1
chr2_+_189784435 1.49 ENST00000409985.5
ENST00000441310.7
ENST00000446877.5
ENST00000409823.7
ENST00000374826.8
ENST00000424766.5
ENST00000447232.6
PMS1
PMS1 homolog 1, mismatch repair system component
chr15_+_77420880 1.41 ENST00000336216.9
ENST00000558176.1
HMG20A
high mobility group 20A
chr17_-_13601901 1.32 ENST00000284110.2
HS3ST3A1
heparan sulfate-glucosamine 3-sulfotransferase 3A1
chr1_+_206897435 1.10 ENST00000391929.7
ENST00000294984.7
ENST00000611909.4
ENST00000367093.3
IL24
interleukin 24
chr3_-_48301577 1.03 ENST00000451657.6
NME6
NME/NM23 nucleoside diphosphate kinase 6
chr6_+_151239951 0.99 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chr15_-_74695987 0.70 ENST00000563009.5
ENST00000568176.5
ENST00000566243.5
ENST00000566219.1
ENST00000426797.7
ENST00000315127.9
ENST00000566119.5
EDC3
enhancer of mRNA decapping 3
chr1_-_15585015 0.69 ENST00000375826.4
AGMAT
agmatinase
chr22_+_41301514 0.60 ENST00000352645.5
ZC3H7B
zinc finger CCCH-type containing 7B
chr6_+_122399536 0.53 ENST00000452194.5
HSF2
heat shock transcription factor 2
chr17_+_77405070 0.47 ENST00000585930.5
SEPTIN9
septin 9
chr5_-_137754327 0.33 ENST00000314940.7
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr6_+_5261497 0.12 ENST00000274680.9
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr12_-_54280087 0.02 ENST00000209875.9
CBX5
chromobox 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.6 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
5.9 29.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
5.4 21.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
3.7 36.9 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
3.0 17.8 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
2.2 32.5 GO:0032836 glomerular basement membrane development(GO:0032836)
2.0 7.8 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
1.9 11.2 GO:0048254 snoRNA localization(GO:0048254)
1.7 7.0 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.7 8.3 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
1.5 9.2 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
1.5 9.0 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
1.5 4.5 GO:0042704 uterine wall breakdown(GO:0042704)
1.5 25.2 GO:0070314 G1 to G0 transition(GO:0070314)
1.4 4.2 GO:0071464 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) cellular response to hydrostatic pressure(GO:0071464)
1.4 16.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
1.3 10.1 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
1.2 6.2 GO:0046070 dGTP metabolic process(GO:0046070)
1.2 3.7 GO:1901389 regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
1.1 10.3 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
1.0 6.2 GO:0051167 glucuronate catabolic process(GO:0006064) glucuronate catabolic process to xylulose 5-phosphate(GO:0019640) L-ascorbic acid biosynthetic process(GO:0019853) xylulose 5-phosphate metabolic process(GO:0051167) xylulose 5-phosphate biosynthetic process(GO:1901159)
1.0 12.4 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
1.0 3.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
1.0 7.1 GO:0007000 nucleolus organization(GO:0007000)
1.0 10.6 GO:0042262 DNA protection(GO:0042262)
0.9 8.3 GO:0070836 caveola assembly(GO:0070836)
0.9 13.2 GO:0006983 ER overload response(GO:0006983)
0.8 7.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.7 3.6 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.7 7.5 GO:0042117 monocyte activation(GO:0042117)
0.7 3.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.6 18.4 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.6 46.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.6 49.1 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.6 2.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.5 13.1 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.5 28.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.4 2.0 GO:0016078 tRNA catabolic process(GO:0016078)
0.4 3.6 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.4 1.8 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.3 6.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.3 1.5 GO:2000769 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.3 2.6 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3 3.1 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.3 3.6 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.3 4.3 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.2 7.8 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.2 0.7 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.2 4.3 GO:0048305 immunoglobulin secretion(GO:0048305)
0.2 6.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 8.2 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.2 2.4 GO:0034638 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.2 3.9 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.1 5.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 9.7 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.1 2.3 GO:0033197 response to vitamin E(GO:0033197)
0.1 1.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 6.6 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 2.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 9.0 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 1.0 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 1.1 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.8 GO:0016233 telomere capping(GO:0016233)
0.0 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 1.3 GO:0006024 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 50.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
1.4 11.2 GO:0070761 pre-snoRNP complex(GO:0070761)
1.4 18.2 GO:0005688 U6 snRNP(GO:0005688)
1.2 3.7 GO:1990913 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
1.0 4.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.9 35.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.8 4.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.7 6.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.6 7.9 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.5 27.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 2.3 GO:0035061 interchromatin granule(GO:0035061)
0.5 20.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.4 5.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.4 28.1 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.4 8.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 7.4 GO:0005861 troponin complex(GO:0005861)
0.3 60.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 2.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 17.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 6.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 9.2 GO:0051233 spindle midzone(GO:0051233)
0.2 13.1 GO:0043198 dendritic shaft(GO:0043198)
0.2 10.7 GO:0030673 axolemma(GO:0030673)
0.2 16.4 GO:0005771 multivesicular body(GO:0005771)
0.2 0.8 GO:1990879 CST complex(GO:1990879)
0.2 12.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.5 GO:0032389 MutLalpha complex(GO:0032389)
0.1 12.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 14.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 3.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 2.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 3.5 GO:0032040 small-subunit processome(GO:0032040)
0.1 39.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 1.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 3.1 GO:0009925 basal plasma membrane(GO:0009925)
0.1 2.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 13.7 GO:0005840 ribosome(GO:0005840)
0.1 8.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 3.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.5 GO:0005643 nuclear pore(GO:0005643)
0.0 5.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 8.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.1 33.3 GO:0004639 phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
6.5 19.6 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
2.7 21.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
2.5 10.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
1.8 18.2 GO:0042731 PH domain binding(GO:0042731)
1.7 25.2 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
1.6 7.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
1.5 10.6 GO:0030613 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
1.2 3.7 GO:0002135 CTP binding(GO:0002135)
1.0 3.0 GO:0008169 C-methyltransferase activity(GO:0008169)
1.0 3.9 GO:0004461 lactose synthase activity(GO:0004461)
0.9 16.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.9 4.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.8 4.2 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.7 11.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.7 3.6 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.7 6.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.7 12.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176) transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.7 6.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.5 29.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.5 7.4 GO:0031014 troponin T binding(GO:0031014)
0.4 2.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.4 1.8 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 1.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3 9.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 2.6 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.3 9.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 8.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.3 7.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 3.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 7.8 GO:0019843 rRNA binding(GO:0019843)
0.2 3.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 6.6 GO:0001671 ATPase activator activity(GO:0001671)
0.2 7.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 37.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 9.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 2.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 4.8 GO:0030515 snoRNA binding(GO:0030515)
0.1 6.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 8.3 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 2.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 2.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 8.7 GO:0051213 dioxygenase activity(GO:0051213)
0.1 10.6 GO:0008013 beta-catenin binding(GO:0008013)
0.1 17.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 13.1 GO:0005178 integrin binding(GO:0005178)
0.1 3.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.8 GO:0043047 single-stranded telomeric DNA binding(GO:0043047)
0.1 1.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 3.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 2.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 1.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 61.4 GO:0003723 RNA binding(GO:0003723)
0.0 3.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 1.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0004905 type I interferon receptor activity(GO:0004905)
0.0 1.5 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 9.4 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.4 10.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 11.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 16.4 PID MYC PATHWAY C-MYC pathway
0.3 12.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 33.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 20.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 8.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 7.8 PID E2F PATHWAY E2F transcription factor network
0.1 3.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 6.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 4.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 36.9 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.5 30.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.0 18.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.6 10.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.6 32.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.4 13.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.4 10.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 12.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 25.6 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.3 6.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 3.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 3.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 2.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 7.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.8 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 1.5 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 3.1 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 3.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.3 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 4.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation