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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BRCA1
Z-value: 0.41
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Transcription factors associated with BRCA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BRCA1 | hg38_v1_chr17_-_43125300_43125331 | -0.13 | 5.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BRCA1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_59630806 Show fit | 9.12 |
ENST00000342503.8
|
reticulon 1 |
|
| chr14_-_59630582 Show fit | 8.68 |
ENST00000395090.5
|
reticulon 1 |
|
| chr2_-_49973939 Show fit | 5.80 |
ENST00000630656.1
|
neurexin 1 |
|
| chr3_-_127736329 Show fit | 4.97 |
ENST00000398101.7
|
monoglyceride lipase |
|
| chr1_+_84181630 Show fit | 4.01 |
ENST00000610457.1
|
protein kinase cAMP-activated catalytic subunit beta |
|
| chr19_-_12801787 Show fit | 3.35 |
ENST00000334482.9
ENST00000301522.3 |
peroxiredoxin 2 |
|
| chr1_+_159171607 Show fit | 3.25 |
ENST00000368124.8
ENST00000368125.9 ENST00000416746.1 |
cell adhesion molecule 3 |
|
| chr2_-_49974083 Show fit | 3.15 |
ENST00000636345.1
|
neurexin 1 |
|
| chr1_-_170074568 Show fit | 2.94 |
ENST00000367767.5
ENST00000361580.7 ENST00000538366.5 |
kinesin associated protein 3 |
|
| chr19_+_55675191 Show fit | 2.37 |
ENST00000270460.11
ENST00000085079.11 |
epsin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.0 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.6 | 5.0 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.0 | 4.2 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.7 | 4.0 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 3.4 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.1 | 3.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 1.0 | 2.9 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.7 | 2.9 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 0.0 | 2.4 | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) |
| 0.1 | 1.9 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 9.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 5.0 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.1 | 4.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.2 | 4.2 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.2 | 4.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 3.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.0 | 2.9 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.0 | 2.4 | GO:0005905 | clathrin-coated pit(GO:0005905) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.0 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.3 | 5.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.3 | 4.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 3.8 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.4 | 3.4 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 1.0 | 2.9 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.0 | 2.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 1.9 | GO:0051430 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.1 | 1.8 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 1.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.1 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.5 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 4.2 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.2 | 3.6 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 2.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.4 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.9 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.0 | 1.8 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.1 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.9 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |