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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for BRCA1

Z-value: 0.41

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.23 BRCA1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg38_v1_chr17_-_43125300_43125331-0.135.2e-02Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_-_59630806 9.12 ENST00000342503.8
RTN1
reticulon 1
chr14_-_59630582 8.68 ENST00000395090.5
RTN1
reticulon 1
chr2_-_49973939 5.80 ENST00000630656.1
NRXN1
neurexin 1
chr3_-_127736329 4.97 ENST00000398101.7
MGLL
monoglyceride lipase
chr1_+_84181630 4.01 ENST00000610457.1
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr19_-_12801787 3.35 ENST00000334482.9
ENST00000301522.3
PRDX2
peroxiredoxin 2
chr1_+_159171607 3.25 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr2_-_49974083 3.15 ENST00000636345.1
NRXN1
neurexin 1
chr1_-_170074568 2.94 ENST00000367767.5
ENST00000361580.7
ENST00000538366.5
KIFAP3
kinesin associated protein 3
chr19_+_55675191 2.37 ENST00000270460.11
ENST00000085079.11
EPN1
epsin 1
chr11_+_118077067 1.92 ENST00000522307.5
ENST00000523251.5
ENST00000437212.8
ENST00000522824.5
ENST00000522151.5
TMPRSS4
transmembrane serine protease 4
chr20_+_58907981 1.88 ENST00000656419.1
GNAS
GNAS complex locus
chr11_+_118077009 1.87 ENST00000616579.4
ENST00000534111.5
TMPRSS4
transmembrane serine protease 4
chr2_-_151261839 1.84 ENST00000331426.6
RBM43
RNA binding motif protein 43
chr8_-_80171106 1.84 ENST00000519303.6
TPD52
tumor protein D52
chr8_+_22605018 1.80 ENST00000389279.7
CCAR2
cell cycle and apoptosis regulator 2
chr19_-_34677157 1.78 ENST00000601241.6
SCGB2B2
secretoglobin family 2B member 2
chrX_+_10156960 1.75 ENST00000380833.9
CLCN4
chloride voltage-gated channel 4
chr6_+_12717660 1.64 ENST00000674637.1
PHACTR1
phosphatase and actin regulator 1
chr11_-_61429934 1.64 ENST00000541963.5
ENST00000477890.6
ENST00000439958.8
CPSF7
cleavage and polyadenylation specific factor 7
chr4_-_48780242 1.63 ENST00000507711.5
ENST00000358350.9
FRYL
FRY like transcription coactivator
chr3_-_142448060 1.50 ENST00000264951.8
XRN1
5'-3' exoribonuclease 1
chr11_-_61430008 1.50 ENST00000394888.8
CPSF7
cleavage and polyadenylation specific factor 7
chr1_-_160262522 1.41 ENST00000440682.5
DCAF8
DDB1 and CUL4 associated factor 8
chr3_-_142448028 1.40 ENST00000392981.7
XRN1
5'-3' exoribonuclease 1
chr1_-_160262501 1.38 ENST00000447377.5
DCAF8
DDB1 and CUL4 associated factor 8
chr10_-_73625951 1.37 ENST00000433394.1
ENST00000422491.7
USP54
ubiquitin specific peptidase 54
chr10_-_100529854 1.33 ENST00000370320.4
ENST00000299166.9
ENST00000370322.5
NDUFB8
NADH:ubiquinone oxidoreductase subunit B8
chr11_+_33258304 1.32 ENST00000531504.5
ENST00000456517.2
HIPK3
homeodomain interacting protein kinase 3
chr6_-_158999748 1.30 ENST00000449822.5
RSPH3
radial spoke head 3
chr11_+_73308237 1.28 ENST00000263674.4
ARHGEF17
Rho guanine nucleotide exchange factor 17
chr6_-_159000174 1.28 ENST00000367069.7
RSPH3
radial spoke head 3
chr2_+_203014842 1.22 ENST00000683969.1
ENST00000449802.5
NBEAL1
neurobeachin like 1
chr13_-_49444004 1.14 ENST00000410043.5
ENST00000409308.6
CAB39L
calcium binding protein 39 like
chr9_-_21031614 1.14 ENST00000495827.3
HACD4
3-hydroxyacyl-CoA dehydratase 4
chr7_-_78771265 1.13 ENST00000630991.2
ENST00000629359.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr12_+_57459782 1.11 ENST00000228682.7
GLI1
GLI family zinc finger 1
chr11_-_61429715 1.08 ENST00000449811.5
ENST00000413232.5
ENST00000340437.8
ENST00000539952.5
ENST00000544585.5
ENST00000450000.5
CPSF7
cleavage and polyadenylation specific factor 7
chr16_-_740934 1.05 ENST00000540986.5
CIAO3
cytosolic iron-sulfur assembly component 3
chr10_-_49269 1.01 ENST00000562809.1
ENST00000568866.5
ENST00000561967.1
ENST00000568584.6
TUBB8
tubulin beta 8 class VIII
chr16_-_740980 1.00 ENST00000251588.7
CIAO3
cytosolic iron-sulfur assembly component 3
chr11_-_27700447 0.97 ENST00000356660.9
BDNF
brain derived neurotrophic factor
chr14_+_20190896 0.93 ENST00000641879.2
ENST00000641682.1
OR11G2
olfactory receptor family 11 subfamily G member 2
chr1_-_160262540 0.86 ENST00000368074.6
DCAF8
DDB1 and CUL4 associated factor 8
chr1_-_160262407 0.83 ENST00000419626.1
ENST00000610139.5
ENST00000475733.5
ENST00000407642.6
ENST00000368073.7
ENST00000326837.6
DCAF8
DDB1 and CUL4 associated factor 8
chr1_+_62597510 0.79 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr14_-_68794597 0.73 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein like 1
chr18_-_49557 0.60 ENST00000308911.8
TUBB8B
tubulin beta 8B
chr14_+_88385643 0.56 ENST00000393545.9
ENST00000356583.9
ENST00000555401.5
ENST00000553885.5
SPATA7
spermatogenesis associated 7
chr11_-_27700472 0.55 ENST00000418212.5
ENST00000533246.5
BDNF
brain derived neurotrophic factor
chr13_+_27251569 0.53 ENST00000272274.8
ENST00000319826.8
ENST00000326092.8
RPL21
ribosomal protein L21
chr19_+_44891206 0.52 ENST00000405636.6
ENST00000252487.9
ENST00000592434.5
ENST00000589649.1
ENST00000426677.7
TOMM40
translocase of outer mitochondrial membrane 40
chr4_+_625555 0.49 ENST00000496514.6
ENST00000255622.10
PDE6B
phosphodiesterase 6B
chr11_+_101914997 0.45 ENST00000263468.13
CEP126
centrosomal protein 126
chr18_+_44697118 0.44 ENST00000677077.1
SETBP1
SET binding protein 1
chr13_+_29428709 0.43 ENST00000542829.1
MTUS2
microtubule associated scaffold protein 2
chr20_-_49913693 0.43 ENST00000422556.1
SPATA2
spermatogenesis associated 2
chr11_+_1099730 0.39 ENST00000674892.1
MUC2
mucin 2, oligomeric mucus/gel-forming
chr19_-_47886308 0.38 ENST00000222002.4
SULT2A1
sulfotransferase family 2A member 1
chr17_-_43661915 0.35 ENST00000318579.9
ENST00000393661.2
MEOX1
mesenchyme homeobox 1
chr4_-_184649436 0.31 ENST00000308394.9
ENST00000517513.5
ENST00000447121.2
ENST00000393588.8
ENST00000523916.5
CASP3
caspase 3
chr2_-_144517663 0.25 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
ZEB2
zinc finger E-box binding homeobox 2
chr13_+_29428603 0.22 ENST00000380808.6
MTUS2
microtubule associated scaffold protein 2
chr3_-_116445458 0.17 ENST00000490035.7
LSAMP
limbic system associated membrane protein
chr12_-_116881062 0.14 ENST00000550505.5
HRK
harakiri, BCL2 interacting protein
chr19_-_39834127 0.13 ENST00000601972.1
ENST00000430012.6
ENST00000323039.10
ENST00000348817.7
DYRK1B
dual specificity tyrosine phosphorylation regulated kinase 1B
chr12_-_116881431 0.12 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein
chr13_-_51974775 0.11 ENST00000674147.1
ATP7B
ATPase copper transporting beta
chr13_+_27251545 0.02 ENST00000311549.11
RPL21
ribosomal protein L21

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.8 9.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.7 2.9 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.7 4.0 GO:0097338 response to clozapine(GO:0097338)
0.6 5.0 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.5 1.5 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.4 1.1 GO:0060032 notochord regression(GO:0060032)
0.2 0.7 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.2 1.0 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.1 0.4 GO:0030573 bile acid catabolic process(GO:0030573)
0.1 1.8 GO:1901978 positive regulation of cell cycle checkpoint(GO:1901978)
0.1 1.9 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.4 GO:0061056 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.1 3.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.8 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.1 1.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.1 GO:0042761 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 1.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.6 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.1 3.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 4.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.3 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 2.4 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0 0.1 GO:0060003 copper ion export(GO:0060003)
0.0 1.8 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.5 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.8 GO:0030183 B cell differentiation(GO:0030183)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0016939 kinesin II complex(GO:0016939)
0.6 1.8 GO:0044609 DBIRD complex(GO:0044609)
0.2 4.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 4.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.4 GO:0070701 mucus layer(GO:0070701)
0.1 4.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.0 GO:0072687 meiotic spindle(GO:0072687)
0.1 17.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 9.0 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.6 GO:0097546 ciliary base(GO:0097546)
0.0 1.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 3.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 5.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 1.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.3 GO:0031264 death-inducing signaling complex(GO:0031264)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.4 3.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.4 1.5 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.4 9.0 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.3 5.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 4.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 1.1 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 1.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.9 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 3.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 2.9 GO:0019894 kinesin binding(GO:0019894)
0.0 1.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.8 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 1.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0016004 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) phospholipase activator activity(GO:0016004)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.4 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 PID IL3 PATHWAY IL3-mediated signaling events
0.0 2.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 4.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 3.6 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 2.9 REACTOME KINESINS Genes involved in Kinesins
0.1 2.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.9 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 1.1 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 1.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway