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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CACAGUG
Z-value: 0.44
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miRNA associated with seed CACAGUG
Network of associatons between targets according to the STRING database.
First level regulatory network of CACAGUG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_65488735 Show fit | 9.95 |
ENST00000338957.4
|
zinc finger CCCH-type containing 12B |
|
| chr2_-_9003657 Show fit | 4.51 |
ENST00000462696.1
ENST00000305997.8 |
membrane bound O-acyltransferase domain containing 2 |
|
| chr6_+_11537738 Show fit | 4.31 |
ENST00000379426.2
|
transmembrane protein 170B |
|
| chr7_-_103989649 Show fit | 4.05 |
ENST00000428762.6
|
reelin |
|
| chr16_-_4242068 Show fit | 3.87 |
ENST00000399609.7
|
sarcalumenin |
|
| chr16_-_70685975 Show fit | 3.85 |
ENST00000338779.11
|
MTSS I-BAR domain containing 2 |
|
| chr17_+_49788672 Show fit | 3.64 |
ENST00000454930.6
ENST00000259021.9 ENST00000509773.5 ENST00000510819.5 ENST00000424009.6 |
lysine acetyltransferase 7 |
|
| chr1_-_39672080 Show fit | 3.48 |
ENST00000235628.2
|
5'-nucleotidase, cytosolic IA |
|
| chrX_-_40735476 Show fit | 3.42 |
ENST00000324817.6
|
mediator complex subunit 14 |
|
| chr11_-_18634332 Show fit | 3.30 |
ENST00000336349.6
|
SPT2 chromatin protein domain containing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.2 | 4.5 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 1.1 | 4.2 | GO:0060535 | trachea cartilage morphogenesis(GO:0060535) |
| 0.0 | 4.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.3 | 4.0 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 0.0 | 3.8 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.7 | 3.6 | GO:0072708 | response to sorbitol(GO:0072708) response to actinomycin D(GO:0072716) |
| 0.2 | 3.5 | GO:0009128 | purine nucleoside monophosphate catabolic process(GO:0009128) |
| 0.0 | 3.4 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 1.1 | 3.3 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 3.9 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 3.8 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 3.5 | GO:0043204 | perikaryon(GO:0043204) |
| 0.7 | 3.4 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 3.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 3.2 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 3.1 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 3.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.5 | 2.8 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.0 | 7.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 4.5 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 4.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 1.0 | 4.0 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.2 | 3.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.3 | 3.3 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.3 | 3.1 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.2 | 2.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 2.9 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.1 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 3.0 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 3.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 2.7 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 2.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 4.5 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.2 | 3.5 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.2 | 3.4 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 3.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 3.2 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 3.0 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 3.0 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 2.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 2.8 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |