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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CAGUAAC

Z-value: 0.64

Motif logo

miRNA associated with seed CAGUAAC

NamemiRBASE accession

Activity profile of CAGUAAC motif

Sorted Z-values of CAGUAAC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CAGUAAC

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_62437015 11.20 ENST00000339950.5
ubiquitin specific peptidase 1
chr15_+_52019206 10.58 ENST00000681888.1
ENST00000261845.7
ENST00000680066.1
ENST00000680777.1
ENST00000680652.1
mitogen-activated protein kinase 6
chr1_-_63523175 10.57 ENST00000371092.7
ENST00000271002.15
integrin subunit beta 3 binding protein
chr3_+_23805941 10.21 ENST00000306627.8
ENST00000346855.7
ubiquitin conjugating enzyme E2 E1
chr3_+_152299392 9.71 ENST00000498502.5
ENST00000545754.5
ENST00000357472.7
ENST00000324196.9
muscleblind like splicing regulator 1
chr5_+_177592182 8.43 ENST00000332598.7
transmembrane p24 trafficking protein 9
chr2_-_197499826 7.26 ENST00000439605.2
ENST00000388968.8
ENST00000418022.2
heat shock protein family D (Hsp60) member 1
chr4_-_186723776 7.16 ENST00000614102.4
ENST00000441802.7
FAT atypical cadherin 1
chr14_+_57268963 7.16 ENST00000261558.8
adaptor related protein complex 5 subunit mu 1
chr3_-_72446623 7.03 ENST00000477973.4
RING1 and YY1 binding protein
chr13_+_97953652 6.94 ENST00000460070.6
ENST00000481455.6
ENST00000261574.10
ENST00000651721.2
ENST00000493281.6
ENST00000463157.6
ENST00000471898.5
ENST00000489058.6
ENST00000481689.6
importin 5
chr2_-_86194972 6.67 ENST00000254636.9
inner membrane mitochondrial protein
chr14_+_93207229 6.38 ENST00000554232.5
ENST00000556871.5
ENST00000013070.11
ENST00000555113.5
ubiquitin protein ligase E3 component n-recognin 7
chr1_+_193121950 6.00 ENST00000367435.5
cell division cycle 73
chr5_+_151771884 5.79 ENST00000627077.2
ENST00000678976.1
ENST00000677408.1
ENST00000678070.1
ENST00000678964.1
ENST00000678925.1
ENST00000394123.7
ENST00000522761.6
ENST00000676827.1
G3BP stress granule assembly factor 1
chr19_+_41262480 5.75 ENST00000352456.7
ENST00000595018.5
ENST00000597725.5
heterogeneous nuclear ribonucleoprotein U like 1
chr16_-_47143934 5.55 ENST00000562435.6
neuropilin and tolloid like 2
chr2_+_231056845 5.34 ENST00000677230.1
ENST00000677259.1
ENST00000677180.1
ENST00000409643.6
ENST00000619128.5
ENST00000678679.1
ENST00000676740.1
ENST00000308696.11
ENST00000440838.5
ENST00000373635.9
proteasome 26S subunit, non-ATPase 1
chr9_-_32573150 5.29 ENST00000379847.8
ENST00000350021.2
NADH:ubiquinone oxidoreductase subunit B6
chr2_-_69387188 4.98 ENST00000674507.1
ENST00000357308.9
glutamine--fructose-6-phosphate transaminase 1
chr20_-_45348414 4.94 ENST00000372733.3
syndecan 4
chr5_+_66144288 4.93 ENST00000334121.11
splicing regulatory glutamic acid and lysine rich protein 1
chr12_-_79690957 4.90 ENST00000328827.9
pro-apoptotic WT1 regulator
chr12_+_130872037 4.81 ENST00000448750.7
ENST00000541630.5
ENST00000543796.6
ENST00000392369.6
ENST00000535090.5
ENST00000541679.7
ENST00000392367.4
RAN, member RAS oncogene family
chr14_+_51240205 4.70 ENST00000457354.7
thioredoxin related transmembrane protein 1
chr22_-_19479160 4.48 ENST00000399523.5
ENST00000421968.6
ENST00000263202.15
ENST00000447868.5
ubiquitin recognition factor in ER associated degradation 1
chr9_+_36572854 4.47 ENST00000543751.5
ENST00000536860.5
ENST00000541717.4
ENST00000536329.5
ENST00000536987.5
ENST00000298048.7
ENST00000495529.5
ENST00000545008.5
maternal embryonic leucine zipper kinase
chr12_+_32679200 4.38 ENST00000452533.6
ENST00000414834.6
dynamin 1 like
chr2_+_227472132 4.25 ENST00000409979.6
ENST00000310078.13
ArfGAP with FG repeats 1
chr12_+_70243412 4.00 ENST00000550160.5
ENST00000551132.5
ENST00000552915.5
ENST00000550641.6
ENST00000229195.8
ENST00000552483.5
CCR4-NOT transcription complex subunit 2
chr10_-_125160499 3.98 ENST00000494626.6
ENST00000337195.9
C-terminal binding protein 2
chr8_-_129939694 3.74 ENST00000522250.5
ENST00000522941.5
ENST00000522746.5
ENST00000520204.5
ENST00000519070.5
ENST00000520254.5
ENST00000519824.6
CYFIP related Rac1 interactor B
chr10_+_22321056 3.69 ENST00000376663.8
BMI1 proto-oncogene, polycomb ring finger
chr12_-_117190456 3.67 ENST00000330622.9
ENST00000622495.5
ENST00000427718.6
F-box protein 21
chr17_-_50866347 3.63 ENST00000499247.3
transducer of ERBB2, 1
chr4_+_143513661 3.57 ENST00000283131.4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr11_+_114400592 3.56 ENST00000541475.5
RNA binding motif protein 7
chr3_-_52679713 3.44 ENST00000296302.11
ENST00000356770.8
ENST00000337303.8
ENST00000409057.5
ENST00000410007.5
ENST00000409114.7
ENST00000409767.5
ENST00000423351.5
polybromo 1
chr1_+_32013848 3.39 ENST00000327300.12
ENST00000492989.1
KH RNA binding domain containing, signal transduction associated 1
chr16_-_20900319 3.37 ENST00000564349.5
ENST00000324344.9
ERI1 exoribonuclease family member 2
defective in cullin neddylation 1 domain containing 3
chr12_-_120469655 3.37 ENST00000229390.8
serine and arginine rich splicing factor 9
chr7_+_107580215 3.18 ENST00000465919.5
ENST00000005259.9
ENST00000445771.6
ENST00000479917.5
ENST00000421217.5
ENST00000457837.5
B cell receptor associated protein 29
chr22_-_35840218 3.06 ENST00000414461.6
ENST00000416721.6
ENST00000449924.6
ENST00000262829.11
ENST00000397305.3
RNA binding fox-1 homolog 2
chr6_-_116060859 3.03 ENST00000606080.2
fyn related Src family tyrosine kinase
chr3_+_61561561 3.00 ENST00000474889.6
protein tyrosine phosphatase receptor type G
chrX_+_41334154 2.99 ENST00000441189.4
ENST00000644513.1
ENST00000644109.1
ENST00000646122.1
ENST00000644074.1
ENST00000644876.2
ENST00000399959.7
ENST00000646319.1
DEAD-box helicase 3 X-linked
chr4_-_75673112 2.79 ENST00000395719.7
ENST00000677489.1
G3BP stress granule assembly factor 2
chr2_+_169733811 2.78 ENST00000392647.7
kelch like family member 23
chr6_-_16761447 2.67 ENST00000244769.8
ENST00000436367.6
ataxin 1
chr9_+_32384603 2.67 ENST00000541043.5
ENST00000379923.5
ENST00000309951.8
aconitase 1
chr2_+_177212724 2.57 ENST00000677043.1
ENST00000677863.1
ENST00000676681.1
ENST00000678111.1
ENST00000676874.1
ENST00000676736.1
ENST00000411529.6
ENST00000435711.5
heterogeneous nuclear ribonucleoprotein A3
chr17_-_1400168 2.43 ENST00000573026.1
ENST00000575977.1
ENST00000571732.5
ENST00000264335.13
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
chr19_-_58558561 2.40 ENST00000253023.8
ubiquitin conjugating enzyme E2 M
chr3_-_52278620 2.35 ENST00000296490.8
WD repeat domain 82
chr3_+_133574434 2.30 ENST00000508481.5
ENST00000420115.6
ENST00000504867.5
ENST00000507408.5
ENST00000511392.5
ENST00000515421.1
CDV3 homolog
chr17_-_40647809 2.30 ENST00000580419.6
ENST00000348513.12
ENST00000643806.1
ENST00000478349.7
ENST00000264640.9
ENST00000644527.1
ENST00000645104.1
ENST00000577721.6
ENST00000580654.6
ENST00000644701.1
ENST00000646283.1
ENST00000431889.6
ENST00000377808.9
ENST00000447024.6
ENST00000642459.1
ENST00000474246.2
ENST00000647515.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr4_-_101347471 2.16 ENST00000323055.10
ENST00000512215.5
protein phosphatase 3 catalytic subunit alpha
chr5_+_139293728 2.05 ENST00000510056.5
ENST00000511249.5
ENST00000394805.8
ENST00000503811.5
ENST00000618441.5
matrin 3
chr8_+_96493803 1.96 ENST00000518385.5
ENST00000302190.9
syndecan 2
chr10_-_15168667 1.78 ENST00000378165.9
N-myristoyltransferase 2
chr15_-_64703199 1.74 ENST00000559753.1
ENST00000560258.6
ENST00000559912.2
ENST00000326005.10
ornithine decarboxylase antizyme 2
chr2_+_46698909 1.71 ENST00000650611.1
ENST00000306503.5
long intergenic non-protein coding RNA 1118
suppressor of cytokine signaling 5
chr12_-_118359639 1.69 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr1_+_113929600 1.68 ENST00000369558.5
ENST00000369561.8
homeodomain interacting protein kinase 1
chr5_-_128538230 1.65 ENST00000262464.9
fibrillin 2
chr12_-_389249 1.64 ENST00000535014.5
ENST00000543507.1
ENST00000544760.1
ENST00000399788.7
lysine demethylase 5A
chr1_+_26695993 1.64 ENST00000324856.13
ENST00000637465.1
AT-rich interaction domain 1A
chrX_-_133415478 1.64 ENST00000370828.4
glypican 4
chr17_+_68512379 1.60 ENST00000392711.5
ENST00000585427.5
ENST00000589228.6
ENST00000536854.6
ENST00000588702.5
ENST00000589309.5
protein kinase cAMP-dependent type I regulatory subunit alpha
chr4_+_41990496 1.59 ENST00000264451.12
solute carrier family 30 member 9
chr1_-_114757971 1.58 ENST00000261443.9
ENST00000534699.5
ENST00000339438.10
ENST00000358528.9
ENST00000529046.5
ENST00000525970.5
ENST00000369530.5
ENST00000530886.5
ENST00000610726.4
cold shock domain containing E1
chr1_-_77219399 1.57 ENST00000359130.1
ENST00000370812.8
ENST00000445065.5
phosphatidylinositol glycan anchor biosynthesis class K
chr4_-_65670339 1.54 ENST00000273854.7
EPH receptor A5
chr3_-_125055987 1.54 ENST00000311127.9
heart development protein with EGF like domains 1
chr21_-_15064934 1.45 ENST00000400199.5
ENST00000400202.5
ENST00000318948.7
nuclear receptor interacting protein 1
chr17_+_2593628 1.30 ENST00000397195.10
platelet activating factor acetylhydrolase 1b regulatory subunit 1
chr1_+_78004930 1.30 ENST00000370763.6
DnaJ heat shock protein family (Hsp40) member B4
chr2_+_230712817 1.24 ENST00000258418.10
calcium binding protein 39
chr3_+_155870623 1.22 ENST00000295920.7
ENST00000496455.7
guanine monophosphate synthase
chr10_+_22316375 1.21 ENST00000376836.8
ENST00000456711.5
ENST00000444869.5
ENST00000475460.6
ENST00000602390.5
ENST00000489125.2
COMM domain containing 3
COMMD3-BMI1 readthrough
chr16_-_73048104 1.19 ENST00000268489.10
zinc finger homeobox 3
chr6_+_12012304 1.19 ENST00000379388.7
ENST00000627968.2
ENST00000541134.5
HIVEP zinc finger 1
chr14_-_23034878 1.18 ENST00000493471.2
ENST00000460922.2
ENST00000361611.11
proteasome 20S subunit beta 5
chr18_+_49562049 1.18 ENST00000261292.9
ENST00000427224.6
ENST00000580036.5
lipase G, endothelial type
chr12_-_14803462 1.14 ENST00000261167.7
ENST00000535328.1
WW domain binding protein 11
chr5_+_73498408 1.10 ENST00000335895.12
ENST00000678135.1
ENST00000380591.7
ENST00000677654.1
ENST00000507081.6
basic transcription factor 3
chr11_-_58575846 1.07 ENST00000395074.7
leupaxin
chr9_-_38069220 1.04 ENST00000377707.4
SH2 domain containing adaptor protein B
chr1_-_92792396 0.96 ENST00000370331.5
ENST00000540033.2
ecotropic viral integration site 5
chrX_+_135985416 0.91 ENST00000370698.7
ENST00000627534.2
ENST00000370695.8
ENST00000630721.3
ENST00000678163.1
solute carrier family 9 member A6
chr10_-_119872754 0.91 ENST00000360003.7
minichromosome maintenance complex binding protein
chr20_-_543770 0.89 ENST00000460062.7
ENST00000645187.1
ENST00000647348.1
ENST00000217244.9
ENST00000349736.10
casein kinase 2 alpha 1
chr9_-_134068012 0.86 ENST00000303407.12
bromodomain containing 3
chr10_-_92574027 0.83 ENST00000650060.1
ENST00000265986.11
ENST00000679089.1
ENST00000676540.1
ENST00000678673.1
ENST00000677079.1
insulin degrading enzyme
chr12_+_19129689 0.80 ENST00000429027.7
ENST00000540972.5
pleckstrin homology domain containing A5
chr9_-_14314067 0.76 ENST00000397575.7
nuclear factor I B
chr20_+_58651228 0.73 ENST00000361830.7
ENST00000458280.5
ENST00000355957.9
ENST00000312283.12
ENST00000412911.5
ENST00000359617.8
ENST00000371141.8
syntaxin 16
chr17_+_62458641 0.72 ENST00000582809.5
tousled like kinase 2
chr6_+_117675448 0.71 ENST00000368494.4
NUS1 dehydrodolichyl diphosphate synthase subunit
chr1_+_35931076 0.63 ENST00000397828.3
ENST00000373191.9
argonaute RISC catalytic component 3
chr4_+_169620527 0.62 ENST00000360642.7
ENST00000512813.5
ENST00000513761.6
chloride voltage-gated channel 3
chr14_+_102777461 0.59 ENST00000560371.5
ENST00000347662.8
TNF receptor associated factor 3
chr14_+_54567612 0.59 ENST00000251091.9
ENST00000392067.7
ENST00000631086.2
sterile alpha motif domain containing 4A
chr14_-_77616630 0.58 ENST00000216484.7
serine palmitoyltransferase long chain base subunit 2
chr1_-_206772484 0.56 ENST00000423557.1
interleukin 10
chr3_-_47164058 0.50 ENST00000409792.4
SET domain containing 2, histone lysine methyltransferase
chr8_-_56993803 0.42 ENST00000262644.9
3'(2'), 5'-bisphosphate nucleotidase 2
chr3_-_36993103 0.39 ENST00000322716.8
EPM2A interacting protein 1
chr6_+_16129077 0.37 ENST00000356840.8
ENST00000349606.4
myosin regulatory light chain interacting protein
chr3_-_49411917 0.37 ENST00000454011.7
ENST00000445425.6
ENST00000422781.6
ENST00000418115.6
ENST00000678921.2
ENST00000676712.2
ras homolog family member A
chr14_-_89619118 0.33 ENST00000345097.8
ENST00000555855.5
ENST00000555353.5
forkhead box N3
chr1_+_179293760 0.32 ENST00000367619.8
sterol O-acyltransferase 1
chr10_-_59906509 0.30 ENST00000263102.7
coiled-coil domain containing 6
chr2_-_213151590 0.24 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKAROS family zinc finger 2
chr2_-_121285194 0.24 ENST00000263707.6
transcription factor CP2 like 1
chr8_-_118111806 0.23 ENST00000378204.7
exostosin glycosyltransferase 1
chr16_+_12901591 0.22 ENST00000558583.3
shisa family member 9
chr20_+_52972347 0.21 ENST00000371497.10
teashirt zinc finger homeobox 2
chr22_+_20917398 0.18 ENST00000354336.8
CRK like proto-oncogene, adaptor protein
chr15_-_61229297 0.12 ENST00000335670.11
RAR related orphan receptor A
chr2_+_203328378 0.11 ENST00000430418.5
ENST00000261018.12
ENST00000295851.10
ENST00000424558.5
ENST00000417864.5
ENST00000422511.6
abl interactor 2
chr1_+_12063285 0.08 ENST00000263932.7
TNF receptor superfamily member 8
chr2_+_191678122 0.07 ENST00000425611.9
ENST00000410026.7
nucleic acid binding protein 1
chr20_-_14337602 0.07 ENST00000378053.3
ENST00000341420.5
fibronectin leucine rich transmembrane protein 3
chr5_-_84384871 0.06 ENST00000296591.10
EGF like repeats and discoidin domains 3
chr3_-_120094436 0.01 ENST00000264235.13
ENST00000677034.1
glycogen synthase kinase 3 beta
chr8_+_80485641 0.00 ENST00000430430.5
zinc finger and BTB domain containing 10

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0002368 B cell cytokine production(GO:0002368)
2.1 8.4 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
2.0 6.0 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
1.5 4.4 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
1.3 10.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.0 5.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.8 3.4 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.8 4.9 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.8 2.4 GO:0003064 regulation of heart rate by hormone(GO:0003064) negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.7 11.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.6 3.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.6 3.0 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.6 4.0 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.5 2.2 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.5 4.8 GO:1902570 protein localization to nucleolus(GO:1902570)
0.5 1.6 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.5 6.7 GO:0042407 cristae formation(GO:0042407)
0.5 3.6 GO:0016584 nucleosome positioning(GO:0016584)
0.5 4.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.5 6.9 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.5 5.5 GO:0001675 acrosome assembly(GO:0001675)
0.4 1.8 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
0.4 3.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.4 1.2 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.4 1.6 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.4 3.0 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.4 5.8 GO:0045116 protein neddylation(GO:0045116)
0.3 1.7 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.3 1.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.3 4.5 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.3 1.6 GO:0006344 optic cup formation involved in camera-type eye development(GO:0003408) maintenance of chromatin silencing(GO:0006344)
0.3 2.0 GO:0008218 bioluminescence(GO:0008218)
0.3 7.0 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.3 10.6 GO:0034080 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3 3.7 GO:0007379 segment specification(GO:0007379)
0.3 2.7 GO:0010040 response to iron(II) ion(GO:0010040)
0.3 1.2 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
0.3 5.0 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.3 1.7 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.3 0.6 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.3 0.8 GO:1901143 insulin catabolic process(GO:1901143)
0.2 1.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 1.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 1.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 1.5 GO:0090270 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.2 3.4 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 1.6 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 3.6 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA catabolic process(GO:1902373)
0.2 2.8 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 1.7 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.2 0.6 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.6 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1 0.7 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 1.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.5 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) histone H3-K36 dimethylation(GO:0097676)
0.1 8.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 5.8 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.1 0.6 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 9.2 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 0.4 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 0.4 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 0.9 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 5.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 9.4 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 1.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 1.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 2.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 2.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.8 GO:2000795 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 6.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.7 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 5.8 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 1.6 GO:0006829 zinc II ion transport(GO:0006829)
0.1 4.5 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 4.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.7 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 3.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 8.3 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0045554 TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556)
0.0 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 3.4 GO:0006338 chromatin remodeling(GO:0006338)
0.0 7.2 GO:0007163 establishment or maintenance of cell polarity(GO:0007163)
0.0 0.2 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.9 GO:0071174 mitotic spindle checkpoint(GO:0071174)
0.0 7.0 GO:0016197 endosomal transport(GO:0016197)
0.0 1.6 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 10.6 GO:0016567 protein ubiquitination(GO:0016567)
0.0 2.7 GO:0051168 nuclear export(GO:0051168)
0.0 0.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.9 GO:0007062 sister chromatid cohesion(GO:0007062)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0034515 proteasome storage granule(GO:0034515)
1.1 6.7 GO:0061617 MICOS complex(GO:0061617)
1.0 8.9 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.7 2.7 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.5 6.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.5 3.6 GO:0016589 NURF complex(GO:0016589)
0.4 1.6 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.3 4.8 GO:0090543 Flemming body(GO:0090543)
0.3 4.0 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 2.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.3 4.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 4.0 GO:0097470 ribbon synapse(GO:0097470)
0.2 18.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 3.7 GO:0035102 PRC1 complex(GO:0035102)
0.2 8.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 2.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 2.2 GO:0005955 calcineurin complex(GO:0005955)
0.2 2.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 0.9 GO:0044308 axonal spine(GO:0044308)
0.2 7.4 GO:0090544 BAF-type complex(GO:0090544)
0.1 7.4 GO:0031519 PcG protein complex(GO:0031519)
0.1 0.6 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 1.3 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 7.2 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 1.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 11.2 GO:0005643 nuclear pore(GO:0005643)
0.1 10.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 1.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 5.3 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.6 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 4.9 GO:0043034 costamere(GO:0043034)
0.1 1.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.6 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.9 GO:0042555 MCM complex(GO:0042555)
0.1 16.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 4.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 0.8 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 7.3 GO:0030175 filopodium(GO:0030175)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.8 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.0 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 4.9 GO:0005884 actin filament(GO:0005884)
0.0 1.1 GO:0002102 podosome(GO:0002102)
0.0 6.1 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 3.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 1.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 4.2 GO:0005938 cell cortex(GO:0005938)
0.0 4.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.7 GO:0016605 PML body(GO:0016605)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 3.7 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0001069 regulatory region RNA binding(GO:0001069)
2.0 10.2 GO:0042296 ISG15 transferase activity(GO:0042296)
1.3 4.0 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
1.2 5.0 GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360)
1.2 7.3 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.7 3.0 GO:0043273 CTPase activity(GO:0043273)
0.7 2.7 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.6 4.0 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.5 3.7 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.5 0.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.5 4.8 GO:0070883 pre-miRNA binding(GO:0070883)
0.4 4.5 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.4 2.7 GO:0034046 poly(G) binding(GO:0034046)
0.4 1.8 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.4 2.6 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.4 4.9 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.4 1.6 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.3 1.7 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.3 2.4 GO:0050815 phosphoserine binding(GO:0050815)
0.3 2.4 GO:0019788 NEDD8 transferase activity(GO:0019788) protein-glutamic acid ligase activity(GO:0070739)
0.3 10.6 GO:0004707 MAP kinase activity(GO:0004707)
0.3 1.6 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.3 4.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 6.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.3 0.8 GO:0031626 beta-endorphin binding(GO:0031626)
0.2 2.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.6 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.2 1.6 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.2 4.4 GO:0051400 BH domain binding(GO:0051400)
0.2 3.4 GO:0097602 cullin family protein binding(GO:0097602)
0.2 0.6 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 4.3 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 6.0 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 1.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.2 5.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 0.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 5.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.3 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 1.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 5.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.4 GO:0008143 poly(A) binding(GO:0008143)
0.1 3.0 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 11.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 9.2 GO:0019905 syntaxin binding(GO:0019905)
0.1 7.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 1.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 1.3 GO:0034452 dynactin binding(GO:0034452)
0.1 0.2 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1 5.5 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 2.8 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 0.8 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 5.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 1.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 3.6 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.4 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 1.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 10.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.7 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.6 GO:0035198 miRNA binding(GO:0035198)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.0 6.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 7.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 4.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 4.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 4.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 5.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 4.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 10.6 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 4.9 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 1.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 6.1 PID E2F PATHWAY E2F transcription factor network
0.1 2.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 2.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.0 PID AURORA B PATHWAY Aurora B signaling
0.0 1.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 11.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.7 10.6 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.4 10.2 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.3 8.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.3 1.8 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 4.8 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.2 3.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 7.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 8.3 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 4.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 11.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 5.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.6 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 6.9 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 4.4 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.0 0.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.9 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 2.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases