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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CAGUAGU
Z-value: 0.80
Motif logo
miRNA associated with seed CAGUAGU
Network of associatons between targets according to the STRING database.
First level regulatory network of CAGUAGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 16.0 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.7 | 13.0 | GO:0051195 | negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198) |
| 0.3 | 13.0 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 0.5 | 12.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.0 | 11.0 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 2.1 | 10.6 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.2 | 10.4 | GO:0018196 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.7 | 9.4 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.3 | 9.3 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 1.5 | 9.2 | GO:0008218 | bioluminescence(GO:0008218) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 16.7 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 15.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.3 | 13.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 12.2 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 10.6 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 10.4 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.9 | 9.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.2 | 9.3 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 8.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.2 | 16.9 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 13.0 | GO:0020037 | heme binding(GO:0020037) |
| 0.3 | 12.2 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.7 | 10.6 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 10.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 10.3 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
| 0.2 | 9.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 9.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 2.9 | 8.7 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.3 | 16.0 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.3 | 14.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 10.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 10.6 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.3 | 9.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 7.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 7.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 6.7 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 6.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.4 | 15.3 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.4 | 13.0 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 12.8 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 10.4 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.4 | 9.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.4 | 9.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 7.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 7.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 6.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |