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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CAGUGCA
Z-value: 0.73
Motif logo
miRNA associated with seed CAGUGCA
Network of associatons between targets according to the STRING database.
First level regulatory network of CAGUGCA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 23.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.9 | 13.9 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.3 | 12.9 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.8 | 11.8 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 1.6 | 11.5 | GO:0008215 | spermine metabolic process(GO:0008215) |
| 1.3 | 11.3 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.3 | 11.3 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 1.0 | 11.2 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 2.6 | 10.3 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.0 | 10.0 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.8 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 18.5 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.2 | 17.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.3 | 17.2 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.1 | 12.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 12.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.6 | 11.8 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.2 | 10.9 | GO:0043034 | costamere(GO:0043034) |
| 2.0 | 10.2 | GO:0044094 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 0.2 | 9.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 14.4 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.4 | 13.6 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 1.8 | 12.9 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 0.0 | 12.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 2.9 | 11.8 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.1 | 11.5 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 1.3 | 11.3 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.2 | 11.2 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 1.8 | 10.9 | GO:0034046 | poly(G) binding(GO:0034046) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 14.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 11.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 11.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.3 | 10.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.5 | 10.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 10.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.6 | 8.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 8.0 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 7.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 23.1 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.3 | 15.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 1.0 | 14.6 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.6 | 12.1 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.4 | 11.8 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.6 | 11.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.4 | 10.6 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 9.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.4 | 8.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.6 | 8.5 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |