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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CBFB
Z-value: 0.46
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Transcription factors associated with CBFB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CBFB | hg38_v1_chr16_+_67029093_67029116 | 0.42 | 6.3e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CBFB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_114439424 Show fit | 9.22 |
ENST00000544196.5
ENST00000265881.10 ENST00000539754.5 ENST00000539275.5 |
RNA exonuclease 2 |
|
| chr11_+_114439515 Show fit | 9.18 |
ENST00000539119.5
|
RNA exonuclease 2 |
|
| chr2_-_64653906 Show fit | 6.16 |
ENST00000313349.3
|
SERTA domain containing 2 |
|
| chr10_+_17229267 Show fit | 6.13 |
ENST00000224237.9
|
vimentin |
|
| chr11_-_58575846 Show fit | 5.74 |
ENST00000395074.7
|
leupaxin |
|
| chr3_-_190122317 Show fit | 3.89 |
ENST00000427335.6
|
prolyl 3-hydroxylase 2 |
|
| chr13_-_46182136 Show fit | 3.79 |
ENST00000323076.7
|
lymphocyte cytosolic protein 1 |
|
| chr2_-_157444044 Show fit | 3.58 |
ENST00000264192.8
|
cytohesin 1 interacting protein |
|
| chr12_+_25052634 Show fit | 3.34 |
ENST00000548766.5
|
inositol 1,4,5-triphosphate receptor associated 2 |
|
| chr3_+_157436842 Show fit | 3.28 |
ENST00000295927.4
|
pentraxin 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.4 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.5 | 6.1 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.7 | 5.7 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.2 | 4.0 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 3.9 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.1 | 3.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.1 | 3.3 | GO:1903015 | regulation of exo-alpha-sialidase activity(GO:1903015) |
| 0.0 | 3.3 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.4 | 2.6 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 0.4 | 2.5 | GO:2000501 | regulation of natural killer cell chemotaxis(GO:2000501) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.2 | 9.5 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 6.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 4.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.9 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 3.6 | GO:0005938 | cell cortex(GO:0005938) |
| 0.5 | 3.1 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 2.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.4 | 2.1 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.0 | 1.7 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.4 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 7.2 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 1.2 | 6.1 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.0 | 4.9 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 4.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.0 | 3.9 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) |
| 0.5 | 3.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.3 | 3.1 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.6 | 2.6 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 0.1 | 2.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 3.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.3 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.4 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 1.3 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 4.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 2.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.1 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 1.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.4 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 1.1 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |