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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CCAGUGU
Z-value: 0.64
Motif logo
miRNA associated with seed CCAGUGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-199a-5p
|
MIMAT0000231 |
|
hsa-miR-199b-5p
|
MIMAT0000263 |
Activity profile of CCAGUGU motif
Sorted Z-values of CCAGUGU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CCAGUGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 10.3 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 2.2 | 6.6 | GO:0051295 | establishment of meiotic spindle localization(GO:0051295) |
| 2.2 | 8.8 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 2.1 | 6.4 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 1.9 | 7.8 | GO:1903891 | regulation of ATF6-mediated unfolded protein response(GO:1903891) |
| 1.7 | 8.5 | GO:0035910 | ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
| 1.6 | 4.9 | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) |
| 1.6 | 9.7 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101) |
| 1.4 | 4.2 | GO:0009447 | putrescine catabolic process(GO:0009447) |
| 1.1 | 3.4 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 1.0 | 3.9 | GO:0061443 | ciliary body morphogenesis(GO:0061073) endocardial cushion cell differentiation(GO:0061443) |
| 1.0 | 2.9 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.9 | 2.6 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
| 0.8 | 11.3 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.7 | 2.8 | GO:0072526 | pyridine-containing compound catabolic process(GO:0072526) |
| 0.7 | 2.1 | GO:0034635 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 0.7 | 12.7 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.7 | 10.6 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532) |
| 0.6 | 1.7 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.6 | 2.3 | GO:2000327 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 0.5 | 1.6 | GO:1903570 | regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.5 | 1.5 | GO:0032289 | central nervous system myelin formation(GO:0032289) |
| 0.5 | 3.1 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.5 | 2.0 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
| 0.5 | 2.4 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.5 | 1.4 | GO:0071922 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.4 | 1.7 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.4 | 1.6 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.4 | 2.9 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.4 | 5.7 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.4 | 3.5 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.4 | 2.3 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.4 | 3.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.4 | 6.7 | GO:0034384 | high-density lipoprotein particle clearance(GO:0034384) |
| 0.4 | 2.9 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.4 | 5.7 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.4 | 1.8 | GO:0070295 | renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127) |
| 0.3 | 5.6 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.3 | 3.5 | GO:0007549 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.3 | 1.7 | GO:0031291 | Ran protein signal transduction(GO:0031291) |
| 0.3 | 4.2 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.3 | 1.0 | GO:0043311 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 0.3 | 1.3 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.3 | 1.5 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.3 | 2.1 | GO:0001705 | ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712) |
| 0.3 | 0.6 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.3 | 1.7 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.3 | 2.4 | GO:0060613 | fat pad development(GO:0060613) |
| 0.2 | 0.5 | GO:1900125 | regulation of hyaluronan biosynthetic process(GO:1900125) |
| 0.2 | 8.0 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 0.2 | 2.7 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.2 | 4.4 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.2 | 1.7 | GO:0071651 | mature ribosome assembly(GO:0042256) positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.2 | 4.4 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.2 | 1.9 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.2 | 1.8 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.2 | 3.7 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.2 | 1.2 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.2 | 1.2 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.2 | 0.8 | GO:0060535 | trachea cartilage morphogenesis(GO:0060535) |
| 0.2 | 1.1 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) |
| 0.2 | 1.8 | GO:0060686 | negative regulation of prostatic bud formation(GO:0060686) |
| 0.2 | 1.6 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.2 | 2.8 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.2 | 1.7 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.2 | 1.1 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.2 | 4.5 | GO:2000637 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.2 | 12.8 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
| 0.2 | 1.1 | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport(GO:0090481) |
| 0.1 | 0.7 | GO:0003344 | pericardium morphogenesis(GO:0003344) |
| 0.1 | 0.6 | GO:0009838 | abscission(GO:0009838) |
| 0.1 | 3.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 3.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 2.1 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.1 | 3.0 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.1 | 1.0 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.1 | 1.7 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.1 | 0.4 | GO:0030327 | prenylated protein catabolic process(GO:0030327) |
| 0.1 | 0.8 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.1 | 2.8 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 0.5 | GO:0000451 | rRNA 2'-O-methylation(GO:0000451) |
| 0.1 | 3.5 | GO:1903432 | regulation of TORC1 signaling(GO:1903432) |
| 0.1 | 0.8 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.1 | 3.7 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 2.3 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.1 | 1.0 | GO:0045040 | protein import into mitochondrial outer membrane(GO:0045040) |
| 0.1 | 1.6 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.1 | 2.3 | GO:0033622 | integrin activation(GO:0033622) |
| 0.1 | 0.2 | GO:2000182 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) regulation of progesterone biosynthetic process(GO:2000182) |
| 0.1 | 0.3 | GO:0043321 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 0.1 | 0.6 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.1 | 0.7 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 1.7 | GO:0071670 | smooth muscle cell chemotaxis(GO:0071670) |
| 0.1 | 4.1 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 3.1 | GO:0032094 | response to food(GO:0032094) |
| 0.1 | 4.5 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.1 | 0.7 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 0.2 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.1 | 2.8 | GO:2000758 | positive regulation of peptidyl-lysine acetylation(GO:2000758) |
| 0.1 | 0.5 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.1 | 3.4 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.1 | 6.2 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
| 0.1 | 0.6 | GO:0070862 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.1 | 3.6 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.1 | 1.0 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 0.1 | 1.8 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.1 | 3.1 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.1 | 0.2 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.1 | 5.7 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.1 | 0.5 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.1 | 1.1 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
| 0.1 | 2.4 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 1.5 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.1 | 0.4 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 1.3 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 2.9 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.1 | 0.3 | GO:0060174 | limb bud formation(GO:0060174) |
| 0.1 | 0.2 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
| 0.1 | 0.6 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 3.0 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.0 | 0.3 | GO:0045617 | negative regulation of keratinocyte differentiation(GO:0045617) |
| 0.0 | 0.7 | GO:0060836 | lymphatic endothelial cell differentiation(GO:0060836) |
| 0.0 | 0.2 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.0 | 2.4 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.0 | 0.1 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.0 | 0.5 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.9 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 2.4 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.2 | GO:0060019 | radial glial cell differentiation(GO:0060019) |
| 0.0 | 4.0 | GO:0048704 | embryonic skeletal system morphogenesis(GO:0048704) |
| 0.0 | 1.8 | GO:0030042 | actin filament depolymerization(GO:0030042) |
| 0.0 | 0.9 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 0.0 | GO:0060601 | lateral sprouting from an epithelium(GO:0060601) |
| 0.0 | 0.2 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.0 | 2.0 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 2.3 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 1.0 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.0 | 0.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.5 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 1.5 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.0 | 1.3 | GO:0007588 | excretion(GO:0007588) |
| 0.0 | 0.8 | GO:0050766 | positive regulation of phagocytosis(GO:0050766) |
| 0.0 | 3.2 | GO:0006457 | protein folding(GO:0006457) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 12.7 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 2.0 | 8.0 | GO:0071942 | XPC complex(GO:0071942) |
| 1.3 | 6.6 | GO:0097513 | actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513) |
| 1.2 | 3.7 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.8 | 7.6 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.7 | 1.5 | GO:1903349 | omegasome membrane(GO:1903349) |
| 0.7 | 5.7 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.6 | 2.5 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.6 | 10.3 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.6 | 3.5 | GO:0034448 | EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.5 | 7.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.4 | 4.9 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.4 | 2.9 | GO:0031415 | NatA complex(GO:0031415) |
| 0.4 | 3.5 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.4 | 1.1 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 0.3 | 1.4 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.3 | 7.0 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.3 | 8.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 2.9 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.2 | 1.2 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 2.7 | GO:0090543 | Flemming body(GO:0090543) |
| 0.2 | 2.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.2 | 1.4 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.2 | 1.7 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.2 | 9.7 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.2 | 2.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 1.9 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 6.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 2.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 1.4 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.1 | 2.3 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 2.4 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 4.5 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.1 | 0.6 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 1.1 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 6.9 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 10.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 6.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 0.8 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 1.1 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 0.9 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 2.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 7.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 3.5 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 1.0 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 1.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 5.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.5 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 0.7 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 0.1 | 6.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 1.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 3.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.5 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.0 | 1.0 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.0 | 2.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 4.7 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.5 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.2 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.0 | 2.8 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.6 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 0.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.4 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 1.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 2.4 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 2.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 3.8 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 2.6 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 0.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 2.8 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 0.2 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.8 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.1 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 0.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.2 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 10.3 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 1.5 | 4.5 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 1.4 | 4.3 | GO:0005055 | laminin receptor activity(GO:0005055) |
| 1.1 | 4.4 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) |
| 0.7 | 2.9 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.7 | 2.8 | GO:0002060 | purine nucleobase binding(GO:0002060) |
| 0.7 | 2.0 | GO:0051717 | phosphohistidine phosphatase activity(GO:0008969) bisphosphoglycerate phosphatase activity(GO:0034416) inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) |
| 0.7 | 2.7 | GO:1990189 | peptide-serine-N-acetyltransferase activity(GO:1990189) |
| 0.6 | 1.8 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.5 | 2.6 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.5 | 3.1 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.5 | 1.8 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.4 | 2.2 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.4 | 1.7 | GO:0043273 | CTPase activity(GO:0043273) |
| 0.4 | 2.1 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.4 | 3.5 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.3 | 7.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.3 | 1.6 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.3 | 1.6 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.3 | 6.6 | GO:0043495 | protein anchor(GO:0043495) |
| 0.3 | 2.9 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.3 | 3.4 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.3 | 2.3 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 1.0 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.2 | 12.2 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.2 | 1.8 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.2 | 2.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.2 | 6.6 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.2 | 0.6 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) |
| 0.2 | 4.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.2 | 1.7 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.2 | 4.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 1.3 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.2 | 2.5 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.2 | 1.7 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.2 | 1.0 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.2 | 0.5 | GO:0070039 | rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039) |
| 0.2 | 3.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.2 | 5.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 4.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 8.0 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 1.2 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 1.0 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.1 | 2.4 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 1.1 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.1 | 13.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 2.3 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 3.6 | GO:0008308 | voltage-gated anion channel activity(GO:0008308) |
| 0.1 | 2.1 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 5.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 2.8 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 1.1 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.1 | 3.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 2.6 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 7.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 2.2 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 7.2 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 5.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 1.1 | GO:0005072 | transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072) |
| 0.1 | 3.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 1.6 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 4.6 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 0.9 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 6.9 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 0.5 | GO:0098988 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988) |
| 0.1 | 1.8 | GO:0071949 | FAD binding(GO:0071949) |
| 0.1 | 6.9 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 6.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.3 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 6.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 4.2 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.1 | 0.4 | GO:0044547 | DNA topoisomerase binding(GO:0044547) RS domain binding(GO:0050733) |
| 0.1 | 1.1 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.1 | 0.4 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.1 | 0.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.8 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 2.3 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.8 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 3.4 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 1.4 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.8 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 1.4 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 8.5 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 1.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.8 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 2.6 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.5 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 1.0 | GO:0016860 | intramolecular oxidoreductase activity(GO:0016860) |
| 0.0 | 0.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.5 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 1.2 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.1 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
| 0.0 | 7.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.4 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.4 | 20.0 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.2 | 7.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 7.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 6.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 1.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 2.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 2.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 2.1 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 7.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 2.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 3.0 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 3.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 1.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 2.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 1.8 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 2.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 7.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 2.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 6.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.1 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.4 | 3.9 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 10.3 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.3 | 9.7 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.2 | 8.0 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.2 | 4.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 8.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 2.8 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.2 | 1.7 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.2 | 7.1 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 3.4 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 1.8 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 1.7 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 2.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 11.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 7.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.8 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 2.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 3.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 5.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 0.8 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 1.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 2.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 1.1 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 2.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 0.7 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 1.0 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.3 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 1.5 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.1 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 5.7 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.0 | 2.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 4.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.5 | REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 0.0 | 1.0 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.3 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |