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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CCCUGAG
Z-value: 1.64
Motif logo
miRNA associated with seed CCCUGAG
Network of associatons between targets according to the STRING database.
First level regulatory network of CCCUGAG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_65488735 Show fit | 40.53 |
ENST00000338957.4
|
zinc finger CCCH-type containing 12B |
|
| chr15_+_31326807 Show fit | 30.92 |
ENST00000307145.4
|
Kruppel like factor 13 |
|
| chr9_-_113340248 Show fit | 24.55 |
ENST00000341761.8
ENST00000374195.7 ENST00000374193.9 |
WD repeat domain 31 |
|
| chr1_+_77779618 Show fit | 23.10 |
ENST00000370791.7
ENST00000443751.3 ENST00000645756.1 ENST00000643390.1 ENST00000642959.1 |
mitoguardin 1 |
|
| chr22_-_39152622 Show fit | 22.89 |
ENST00000216133.10
|
chromobox 7 |
|
| chr6_+_11537738 Show fit | 21.66 |
ENST00000379426.2
|
transmembrane protein 170B |
|
| chr19_+_7903843 Show fit | 21.20 |
ENST00000397981.7
ENST00000397979.4 ENST00000397983.7 |
mitogen-activated protein kinase kinase 7 |
|
| chr4_-_2262082 Show fit | 20.51 |
ENST00000337190.7
|
MAX dimerization protein 4 |
|
| chr15_+_74541200 Show fit | 20.31 |
ENST00000622429.1
ENST00000346246.10 |
AT-rich interaction domain 3B |
|
| chr3_-_57693045 Show fit | 20.21 |
ENST00000311128.10
|
DENN domain containing 6A |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 30.9 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.4 | 25.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.9 | 24.9 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.7 | 24.2 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 2.4 | 21.2 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 2.0 | 20.2 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 1.1 | 19.2 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 4.8 | 19.1 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 2.3 | 18.1 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.4 | 18.1 | GO:0006198 | cAMP catabolic process(GO:0006198) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 115.5 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 67.8 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 36.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 32.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 28.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 28.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 24.4 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.3 | 23.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 1.4 | 22.9 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.3 | 22.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 39.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 36.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.0 | 34.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 32.9 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.1 | 28.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.3 | 26.9 | GO:0101005 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 1.3 | 25.8 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.7 | 24.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.3 | 21.8 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.1 | 21.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 74.4 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 44.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 21.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 19.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.2 | 18.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 18.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 18.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 15.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.3 | 14.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 12.5 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 34.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 32.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.4 | 25.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.8 | 24.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.9 | 21.8 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 20.1 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.7 | 15.1 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.6 | 14.6 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.4 | 14.0 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.2 | 13.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |