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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CDC5L
Z-value: 0.81
Motif logo
Transcription factors associated with CDC5L
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CDC5L
|
ENSG00000096401.8 | CDC5L |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CDC5L | hg38_v1_chr6_+_44387686_44387730 | 0.04 | 5.8e-01 | Click! |
Activity profile of CDC5L motif
Sorted Z-values of CDC5L motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CDC5L
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 11.6 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 2.0 | 6.0 | GO:0044007 | negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010768) transmission of virus(GO:0019089) dissemination or transmission of symbiont from host(GO:0044007) dissemination or transmission of organism from other organism involved in symbiotic interaction(GO:0051821) |
| 1.6 | 8.0 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 1.6 | 4.7 | GO:0014810 | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014810) |
| 1.5 | 10.3 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 1.3 | 9.4 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 1.3 | 3.9 | GO:2000296 | negative regulation of hydrogen peroxide catabolic process(GO:2000296) |
| 1.2 | 3.6 | GO:0031455 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 1.2 | 3.5 | GO:1904732 | regulation of electron carrier activity(GO:1904732) |
| 1.1 | 6.9 | GO:0006696 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 1.1 | 3.2 | GO:2000048 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.9 | 3.7 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.9 | 8.1 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.9 | 3.5 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.8 | 3.2 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.8 | 3.8 | GO:0001971 | negative regulation of activation of membrane attack complex(GO:0001971) |
| 0.7 | 6.6 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.7 | 2.2 | GO:0097069 | response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387) |
| 0.7 | 2.9 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.7 | 7.4 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.6 | 3.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.6 | 4.2 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.6 | 4.2 | GO:0090204 | protein localization to nuclear pore(GO:0090204) positive regulation of calcium-transporting ATPase activity(GO:1901896) |
| 0.6 | 1.1 | GO:0035990 | tendon cell differentiation(GO:0035990) tendon formation(GO:0035992) |
| 0.5 | 2.1 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.5 | 2.1 | GO:0006175 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) |
| 0.5 | 2.1 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.5 | 1.6 | GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.5 | 1.5 | GO:1902594 | viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594) |
| 0.5 | 1.4 | GO:0006781 | succinyl-CoA pathway(GO:0006781) |
| 0.5 | 2.4 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.5 | 1.4 | GO:0036233 | glycine import(GO:0036233) |
| 0.5 | 2.8 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.5 | 2.7 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.4 | 3.8 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.4 | 1.6 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.4 | 2.8 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.4 | 1.2 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.4 | 1.5 | GO:0051944 | peptidyl-cysteine methylation(GO:0018125) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) |
| 0.3 | 6.2 | GO:0045086 | positive regulation of interleukin-2 biosynthetic process(GO:0045086) |
| 0.3 | 3.1 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.3 | 8.5 | GO:1900037 | regulation of cellular response to hypoxia(GO:1900037) |
| 0.3 | 2.0 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.3 | 3.0 | GO:0098814 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.3 | 1.3 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 0.3 | 1.3 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.3 | 1.3 | GO:0097325 | melanocyte proliferation(GO:0097325) |
| 0.3 | 1.2 | GO:0048627 | myoblast development(GO:0048627) |
| 0.3 | 0.6 | GO:0042640 | anagen(GO:0042640) |
| 0.3 | 4.6 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 0.3 | 1.2 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.3 | 1.2 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.3 | 2.7 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.3 | 1.7 | GO:0032383 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 0.3 | 1.1 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.3 | 0.8 | GO:0097534 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 0.3 | 1.1 | GO:0072660 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.3 | 2.2 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.3 | 9.0 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.3 | 3.2 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.3 | 5.0 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.3 | 1.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.3 | 0.8 | GO:0021965 | spinal cord ventral commissure morphogenesis(GO:0021965) |
| 0.3 | 1.6 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.3 | 2.3 | GO:0060613 | fat pad development(GO:0060613) |
| 0.3 | 0.5 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 0.2 | 2.9 | GO:0042407 | cristae formation(GO:0042407) |
| 0.2 | 0.9 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 0.2 | 3.6 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.2 | 0.9 | GO:0055011 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.2 | 1.7 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.2 | 6.6 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.2 | 7.8 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.2 | 1.2 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.2 | 1.2 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.2 | 2.0 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.2 | 2.3 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.2 | 2.1 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.2 | 0.6 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.2 | 0.7 | GO:1902725 | negative regulation of satellite cell differentiation(GO:1902725) |
| 0.2 | 0.7 | GO:0090164 | protein retention in Golgi apparatus(GO:0045053) asymmetric Golgi ribbon formation(GO:0090164) |
| 0.2 | 2.2 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.2 | 0.9 | GO:2000320 | T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.2 | 2.4 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.2 | 0.5 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.2 | 1.8 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.2 | 1.8 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
| 0.2 | 1.5 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.2 | 8.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.2 | 1.4 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.2 | 1.3 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.2 | 0.6 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.1 | 1.5 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.1 | 0.4 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 1.7 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.1 | 0.4 | GO:0006533 | aspartate catabolic process(GO:0006533) |
| 0.1 | 4.4 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.1 | 0.8 | GO:1900368 | adenosine to inosine editing(GO:0006382) regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) |
| 0.1 | 0.5 | GO:0032072 | plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426) |
| 0.1 | 1.9 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 2.0 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.1 | 0.6 | GO:2000015 | negative regulation of cell fate commitment(GO:0010454) regulation of determination of dorsal identity(GO:2000015) |
| 0.1 | 1.2 | GO:0097647 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.1 | 0.9 | GO:0009441 | glycolate metabolic process(GO:0009441) |
| 0.1 | 0.7 | GO:0019530 | taurine metabolic process(GO:0019530) |
| 0.1 | 0.3 | GO:0044278 | cell wall disruption in other organism(GO:0044278) |
| 0.1 | 1.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.1 | 1.4 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.1 | 4.0 | GO:0051569 | regulation of histone H3-K4 methylation(GO:0051569) |
| 0.1 | 1.3 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 0.8 | GO:0045040 | protein import into mitochondrial outer membrane(GO:0045040) |
| 0.1 | 0.6 | GO:2000535 | regulation of entry of bacterium into host cell(GO:2000535) |
| 0.1 | 2.7 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 2.6 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.1 | 1.8 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.1 | 0.6 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 0.5 | GO:0097461 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.1 | 0.6 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 2.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 5.9 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 1.2 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.1 | 1.1 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.1 | 0.5 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.1 | 0.8 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 1.2 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.1 | 0.3 | GO:0060974 | neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713) |
| 0.1 | 0.1 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 0.1 | 0.5 | GO:0001554 | luteolysis(GO:0001554) |
| 0.1 | 1.3 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.1 | 0.3 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.1 | 1.9 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
| 0.1 | 1.5 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.1 | 12.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 0.1 | GO:0051552 | flavone metabolic process(GO:0051552) positive regulation of cellular respiration(GO:1901857) |
| 0.1 | 0.6 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
| 0.1 | 0.6 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 3.2 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.1 | 1.7 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.1 | 0.4 | GO:0008295 | spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295) |
| 0.1 | 2.3 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.1 | 1.3 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.1 | 0.8 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.1 | 0.3 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 0.1 | 1.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 0.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 2.0 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 0.2 | GO:0045643 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.1 | 0.9 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
| 0.1 | 0.7 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 0.1 | GO:0070172 | positive regulation of tooth mineralization(GO:0070172) |
| 0.0 | 0.2 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.0 | 0.8 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.2 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.0 | 0.5 | GO:0070989 | oxidative demethylation(GO:0070989) |
| 0.0 | 0.8 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.9 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.0 | 0.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.4 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.0 | 0.5 | GO:0060992 | response to fungicide(GO:0060992) |
| 0.0 | 0.8 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 1.0 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 1.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 1.7 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.0 | 2.5 | GO:0071806 | protein transmembrane transport(GO:0071806) |
| 0.0 | 0.8 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.0 | 0.4 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 0.1 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.0 | 0.2 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 0.2 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.0 | 0.7 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 0.4 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.0 | 1.2 | GO:0006363 | transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363) |
| 0.0 | 0.9 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 0.9 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.0 | 0.4 | GO:0009950 | dorsal/ventral axis specification(GO:0009950) trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.5 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.0 | 0.4 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.0 | 0.9 | GO:0039694 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.0 | 0.4 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.2 | GO:0032769 | glycoside catabolic process(GO:0016139) negative regulation of monooxygenase activity(GO:0032769) negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.0 | 0.7 | GO:0033962 | cytoplasmic mRNA processing body assembly(GO:0033962) |
| 0.0 | 0.2 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.0 | 0.2 | GO:1902358 | sulfate transmembrane transport(GO:1902358) |
| 0.0 | 0.1 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.0 | 1.5 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 0.2 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.0 | 0.2 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 0.0 | 3.4 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 1.3 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.0 | 0.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.1 | GO:0043128 | regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128) |
| 0.0 | 1.0 | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway(GO:2001244) |
| 0.0 | 1.0 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 1.5 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.0 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.0 | 0.2 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.0 | 0.1 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.0 | 0.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.0 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.0 | 0.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 1.3 | GO:0007286 | spermatid development(GO:0007286) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 8.1 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 1.1 | 3.2 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 1.1 | 4.2 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 1.0 | 3.9 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.7 | 2.2 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 0.7 | 2.7 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.6 | 7.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.6 | 1.7 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 0.5 | 3.2 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.5 | 1.6 | GO:0005656 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.5 | 5.0 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.5 | 2.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.5 | 1.4 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.4 | 1.3 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.4 | 1.2 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.4 | 3.8 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.4 | 1.8 | GO:0045273 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.3 | 3.3 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.3 | 9.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.3 | 0.8 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 0.3 | 5.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 0.9 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.2 | 4.6 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 3.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 3.8 | GO:0016342 | catenin complex(GO:0016342) |
| 0.2 | 1.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.2 | 2.4 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.2 | 3.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 4.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.2 | 1.4 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.2 | 2.6 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 1.1 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 1.7 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 1.5 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 3.1 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 1.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 1.3 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 0.8 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 2.9 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 0.8 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 4.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 0.7 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.5 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.1 | 1.4 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 1.5 | GO:0044613 | nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615) |
| 0.1 | 0.6 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 1.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 0.4 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 1.4 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 0.8 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 4.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 5.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 0.6 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.1 | 3.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 0.3 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.1 | 1.6 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.1 | 0.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 3.2 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.6 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 1.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 2.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 10.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 4.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.2 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.0 | 1.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.4 | GO:0071564 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.0 | 2.4 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.5 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.0 | 0.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 1.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 1.0 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.0 | 1.6 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 4.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.4 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 3.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.7 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 1.7 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 0.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 2.4 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.0 | 0.3 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 2.5 | GO:0044455 | mitochondrial membrane part(GO:0044455) |
| 0.0 | 6.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 4.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.1 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 0.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.1 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 1.4 | GO:0031901 | early endosome membrane(GO:0031901) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 9.4 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 1.5 | 10.3 | GO:0102345 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 1.3 | 5.0 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 1.1 | 6.9 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.9 | 4.7 | GO:0050610 | glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
| 0.9 | 2.8 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.9 | 6.4 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.9 | 2.6 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.9 | 6.0 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 0.8 | 8.1 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.7 | 2.2 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 0.7 | 5.4 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.6 | 1.7 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.6 | 1.7 | GO:0004618 | copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682) |
| 0.6 | 1.7 | GO:0080130 | L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.6 | 5.0 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.6 | 3.9 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.5 | 2.1 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.5 | 2.1 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 0.4 | 1.8 | GO:0051538 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.4 | 8.1 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.4 | 4.2 | GO:0044388 | small protein activating enzyme binding(GO:0044388) |
| 0.4 | 1.3 | GO:0052794 | exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796) |
| 0.4 | 1.6 | GO:0033823 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 0.4 | 3.2 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.4 | 1.2 | GO:0019150 | D-ribulokinase activity(GO:0019150) |
| 0.4 | 1.2 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.4 | 1.1 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.4 | 1.9 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.4 | 1.8 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.4 | 1.4 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.3 | 2.5 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.3 | 11.1 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.3 | 0.9 | GO:0003973 | (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854) |
| 0.3 | 1.2 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.3 | 2.4 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.3 | 1.7 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.3 | 0.8 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.3 | 2.7 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.3 | 4.6 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.2 | 3.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 0.7 | GO:0052816 | medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816) |
| 0.2 | 2.2 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.2 | 1.1 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.2 | 1.7 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.2 | 2.3 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.2 | 3.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 1.4 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.2 | 4.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 0.8 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 0.2 | 1.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.2 | 0.9 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.2 | 4.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 6.8 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.2 | 0.6 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 2.9 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 2.2 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 0.4 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 1.4 | GO:0036435 | K48-linked polyubiquitin binding(GO:0036435) |
| 0.1 | 3.7 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.1 | 2.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.5 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
| 0.1 | 1.9 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 1.5 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 0.5 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 0.5 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 3.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 0.6 | GO:0017161 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.1 | 0.8 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.1 | 3.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 2.0 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 3.8 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 1.9 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.1 | 0.5 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 1.6 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.1 | 11.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 0.8 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.1 | 0.6 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 1.5 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 1.8 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 1.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 0.5 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.1 | 2.3 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 10.3 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 9.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 0.7 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.1 | 0.5 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.1 | 0.8 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 3.4 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 1.3 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 0.7 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.1 | 1.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.1 | 0.4 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.1 | 0.6 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 1.5 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 0.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 0.4 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.1 | 0.3 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.1 | 0.3 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.1 | 4.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.3 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 0.3 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.1 | 0.8 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 1.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 2.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 1.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.6 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 0.2 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 0.1 | 1.7 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.1 | 0.5 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.1 | 1.8 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.1 | 1.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.4 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.0 | 3.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.6 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 1.3 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 1.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.6 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 7.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.7 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 5.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.3 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.0 | 0.7 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.9 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.0 | 0.2 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.0 | 0.8 | GO:0098847 | sequence-specific single stranded DNA binding(GO:0098847) |
| 0.0 | 1.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 1.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 2.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 2.0 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.9 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 0.1 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.0 | 0.2 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.0 | 2.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 1.6 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.7 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.3 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.0 | 5.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.1 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 1.4 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 1.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.2 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 0.9 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.1 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.0 | 5.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.2 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.0 | 0.4 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.2 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 0.4 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 0.5 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.3 | GO:0008252 | nucleotidase activity(GO:0008252) |
| 0.0 | 0.2 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.0 | 0.1 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 2.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 11.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 5.1 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.0 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 0.5 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.1 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.8 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 0.5 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.1 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.2 | 11.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 4.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 5.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 3.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 10.3 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 2.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 4.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 7.4 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 5.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 3.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 10.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 16.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 4.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 2.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 3.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 11.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.6 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 0.8 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.5 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 5.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.9 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.1 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.4 | 7.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.3 | 8.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 7.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 4.2 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 6.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 1.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 5.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 1.9 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 2.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 4.0 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 3.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.7 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 4.6 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 1.5 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 4.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 3.2 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 12.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 1.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 3.8 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.1 | 2.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 2.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.1 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 2.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 8.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 4.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 1.2 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.1 | 2.6 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 1.5 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 1.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 6.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.2 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 1.2 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 2.0 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 4.5 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 0.9 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 2.1 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 2.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.9 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 1.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.5 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 1.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 5.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 2.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 5.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 1.6 | REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR) |
| 0.0 | 0.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 2.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 4.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 3.7 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.0 | 0.2 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 2.7 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.0 | 0.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |