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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CDC5L
Z-value: 0.81
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Transcription factors associated with CDC5L
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CDC5L | hg38_v1_chr6_+_44387686_44387730 | 0.04 | 5.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CDC5L
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.3 | 11.6 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 1.5 | 10.3 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 1.3 | 9.4 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.3 | 9.0 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.2 | 8.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.3 | 8.5 | GO:1900037 | regulation of cellular response to hypoxia(GO:1900037) |
| 0.9 | 8.1 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 1.6 | 8.0 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.2 | 7.8 | GO:0048665 | neuron fate specification(GO:0048665) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.3 | 9.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.4 | 8.1 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.6 | 7.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 6.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 5.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.5 | 5.0 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.3 | 5.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 4.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 4.6 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 11.1 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.1 | 11.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.5 | 10.3 | GO:0102345 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 0.1 | 10.3 | GO:0051087 | chaperone binding(GO:0051087) |
| 2.4 | 9.4 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 9.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.8 | 8.1 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.4 | 8.1 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.0 | 7.0 | GO:0008201 | heparin binding(GO:0008201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 11.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 11.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 10.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 10.3 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 8.1 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 7.4 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 5.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 5.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 8.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.5 | 8.1 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.3 | 8.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 7.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.4 | 7.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 6.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 6.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 5.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 5.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |