ISMARA results: CDX1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CDX1

Z-value: 0.88

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Transcription factors associated with CDX1

Gene Symbol	Gene ID	Gene Info
CDX1 Ensembl NCBI GeneCards UniProt	ENSG00000113722.17	CDX1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CDX1	hg38_v1_chr5_+_150166770_150166788, hg38_v1_chr5_+_150166790_150166890	0.47	1.4e-13	Click!

Activity profile of CDX1 motif

Sorted Z-values of CDX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr12_-_9115907 Show fit	15.47	ENST00000318602.12	A2M Ensembl NCBI GeneCards UniProt Show fit	alpha-2-macroglobulin
chr16_+_172869 Show fit	14.46	ENST00000251595.11 ENST00000397806.1 ENST00000484216.1	HBA2 Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit alpha 2
chr12_-_91179472 Show fit	13.09	ENST00000550099.5 ENST00000546391.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr12_-_52385649 Show fit	12.80	ENST00000257951.3	KRT84 Ensembl NCBI GeneCards UniProt Show fit	keratin 84
chr12_-_110920710 Show fit	12.54	ENST00000546404.1	MYL2 Ensembl NCBI GeneCards UniProt Show fit	myosin light chain 2
chr10_-_67838019 Show fit	10.50	ENST00000483798.6	DNAJC12 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member C12
chr10_-_88952763 Show fit	9.58	ENST00000224784.10	ACTA2 Ensembl NCBI GeneCards UniProt Show fit	actin alpha 2, smooth muscle
chr2_-_86105839 Show fit	8.62	ENST00000263857.11	POLR1A Ensembl NCBI GeneCards UniProt Show fit	RNA polymerase I subunit A
chr2_-_178807415 Show fit	8.40	ENST00000342992.10 ENST00000460472.6 ENST00000589042.5 ENST00000591111.5 ENST00000360870.10	TTN Ensembl NCBI GeneCards UniProt Show fit	titin
chr3_-_195583931 Show fit	8.27	ENST00000343267.8 ENST00000421243.5 ENST00000453131.1	APOD Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein D

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	23.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9	21.7	GO:0071294	cellular response to zinc ion(GO:0071294)
1.8	20.1	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
3.1	15.6	GO:0035995	detection of muscle stretch(GO:0035995)
5.2	15.5	GO:0001868	regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
2.3	13.9	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	13.7	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.0	13.1	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.9	12.8	GO:0035878	nail development(GO:0035878)
1.4	12.3	GO:0072564	response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)

Showing 1 to 10 of 173 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	61.2	GO:0005615	extracellular space(GO:0005615)
0.0	23.9	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	20.5	GO:0031093	platelet alpha granule lumen(GO:0031093)
1.3	20.1	GO:0097512	cardiac myofibril(GO:0097512)
0.4	17.7	GO:0045095	keratin filament(GO:0045095)
0.1	15.2	GO:0030018	Z disc(GO:0030018)
0.4	14.5	GO:0031092	platelet alpha granule membrane(GO:0031092)
3.5	13.9	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3	13.9	GO:1902711	GABA-A receptor complex(GO:1902711)
0.3	13.2	GO:0031430	M band(GO:0031430)

Showing 1 to 10 of 85 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	35.7	GO:0005509	calcium ion binding(GO:0005509)
0.2	25.7	GO:0005518	collagen binding(GO:0005518)
0.1	25.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.0	20.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	16.6	GO:0003725	double-stranded RNA binding(GO:0003725)
1.4	15.6	GO:0031433	telethonin binding(GO:0031433)
5.2	15.5	GO:0019959	interleukin-8 binding(GO:0019959)
1.2	14.5	GO:0030280	structural constituent of epidermis(GO:0030280)
1.5	12.3	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.1	10.6	GO:0004984	olfactory receptor activity(GO:0004984)

Showing 1 to 10 of 133 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	28.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	20.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.2	20.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	13.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	12.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	11.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	9.8	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	9.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	8.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	7.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 36 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	37.7	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.1	19.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.6	15.5	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.3	13.9	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.5	13.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	12.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	10.5	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	10.1	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.0	9.8	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	9.1	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression

Showing 1 to 10 of 61 entries

Results for CDX1

Z-value: 0.88

Motif logo

Transcription factors associated with CDX1

Activity-expression correlation:

Activity profile of CDX1 motif

Sorted Z-values of CDX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: