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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CDX2
Z-value: 0.69
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Transcription factors associated with CDX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CDX2 | hg38_v1_chr13_-_27969295_27969350 | 0.08 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CDX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 17.2 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.2 | 15.4 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 3.6 | 10.7 | GO:0015847 | putrescine transport(GO:0015847) |
| 0.7 | 9.3 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.3 | 7.1 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 1.1 | 6.6 | GO:0003051 | angiotensin catabolic process in blood(GO:0002005) angiotensin-mediated drinking behavior(GO:0003051) |
| 0.7 | 6.1 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.1 | 5.8 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 5.8 | GO:0090305 | nucleic acid phosphodiester bond hydrolysis(GO:0090305) |
| 0.2 | 5.7 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 17.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 17.2 | GO:0031514 | motile cilium(GO:0031514) |
| 0.1 | 14.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 12.4 | GO:0016459 | myosin complex(GO:0016459) |
| 0.8 | 9.3 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 6.1 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 5.0 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 4.8 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.9 | 3.8 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.2 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 11.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 11.1 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 3.6 | 10.7 | GO:0015203 | polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489) |
| 1.8 | 7.1 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 1.3 | 6.6 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.1 | 6.5 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 6.4 | GO:0004519 | endonuclease activity(GO:0004519) |
| 1.0 | 5.7 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.1 | 5.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 7.1 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 6.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.7 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 3.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 2.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.7 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 2.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 2.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 9.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 8.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 7.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 4.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 4.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 3.8 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 3.8 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 3.5 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 3.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |