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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CEBPA
Z-value: 1.61
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Transcription factors associated with CEBPA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPA | hg38_v1_chr19_-_33302524_33302542 | 0.63 | 3.9e-25 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.8 | 69.2 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.2 | 66.8 | GO:0002250 | adaptive immune response(GO:0002250) |
| 1.6 | 55.9 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.8 | 54.7 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.8 | 48.9 | GO:0002548 | monocyte chemotaxis(GO:0002548) |
| 9.5 | 47.5 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 5.7 | 39.9 | GO:1990822 | regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822) |
| 3.2 | 35.5 | GO:0051791 | medium-chain fatty acid metabolic process(GO:0051791) |
| 1.7 | 34.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 8.7 | 34.7 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 194.2 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 103.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.6 | 84.9 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 77.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 68.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.3 | 65.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 49.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 5.3 | 47.5 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 41.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 1.8 | 34.7 | GO:0042611 | MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 77.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 76.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 11.5 | 69.2 | GO:0003796 | lysozyme activity(GO:0003796) |
| 1.5 | 56.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 13.1 | 52.3 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 3.3 | 39.9 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 1.4 | 36.2 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 7.1 | 35.5 | GO:0047374 | sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 4.3 | 30.3 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.5 | 29.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 86.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.7 | 72.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.3 | 72.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 55.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 51.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.3 | 46.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 1.6 | 35.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.4 | 30.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.6 | 29.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.9 | 26.0 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 71.7 | REACTOME DEFENSINS | Genes involved in Defensins |
| 1.6 | 71.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 2.0 | 46.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 2.4 | 45.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 3.4 | 43.6 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.2 | 37.9 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.5 | 32.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 32.3 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 1.7 | 31.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.6 | 31.2 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |