ISMARA results: CEBPE

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CEBPE_CEBPD

Z-value: 1.40

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Transcription factors associated with CEBPE_CEBPD

Gene Symbol	Gene ID	Gene Info
CEBPE Ensembl NCBI GeneCards UniProt	ENSG00000092067.6	CEBPE
CEBPD Ensembl NCBI GeneCards UniProt	ENSG00000221869.5	CEBPD

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CEBPD	hg38_v1_chr8_-_47738153_47738173	0.41	4.8e-10	Click!
CEBPE	hg38_v1_chr14_-_23119248_23119265	-0.12	8.4e-02	Click!

Activity profile of CEBPE_CEBPD motif

Sorted Z-values of CEBPE_CEBPD motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPE_CEBPD

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr9_-_91423819 Show fit	42.01	ENST00000297689.4	NFIL3 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor, interleukin 3 regulated
chr5_+_96662214 Show fit	34.61	ENST00000395812.6	CAST Ensembl NCBI GeneCards UniProt Show fit	calpastatin
chr5_+_96662366 Show fit	33.15	ENST00000675179.1 ENST00000421689.6 ENST00000674984.1 ENST00000512620.5	CAST Ensembl NCBI GeneCards UniProt Show fit	calpastatin
chr16_-_84618041 Show fit	32.75	ENST00000564057.1	COTL1 Ensembl NCBI GeneCards UniProt Show fit	coactosin like F-actin binding protein 1
chr5_+_96662314 Show fit	32.63	ENST00000674702.1	CAST Ensembl NCBI GeneCards UniProt Show fit	calpastatin
chr16_-_84618067 Show fit	32.30	ENST00000262428.5	COTL1 Ensembl NCBI GeneCards UniProt Show fit	coactosin like F-actin binding protein 1
chr15_+_45635017 Show fit	31.49	ENST00000260324.12	SQOR Ensembl NCBI GeneCards UniProt Show fit	sulfide quinone oxidoreductase
chr5_+_96662046 Show fit	28.59	ENST00000338252.7 ENST00000508830.5	CAST Ensembl NCBI GeneCards UniProt Show fit	calpastatin
chr3_+_157436842 Show fit	27.54	ENST00000295927.4	PTX3 Ensembl NCBI GeneCards UniProt Show fit	pentraxin 3
chr19_-_40465760 Show fit	27.33	ENST00000643519.1	BLVRB Ensembl NCBI GeneCards UniProt Show fit	biliverdin reductase B

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.6	129.0	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
1.8	75.1	GO:0050832	defense response to fungus(GO:0050832)
4.5	58.0	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
3.7	51.7	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
6.9	48.6	GO:1990822	regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
1.0	42.0	GO:0071353	cellular response to interleukin-4(GO:0071353)
0.3	36.0	GO:0036498	IRE1-mediated unfolded protein response(GO:0036498)
4.9	34.1	GO:0034201	response to oleic acid(GO:0034201)
7.9	31.5	GO:0070221	sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
1.8	27.4	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)

Showing 1 to 10 of 124 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	112.7	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
5.7	51.7	GO:0097452	GAIT complex(GO:0097452)
0.0	49.8	GO:0005615	extracellular space(GO:0005615)
0.1	45.1	GO:0016323	basolateral plasma membrane(GO:0016323)
0.4	45.0	GO:0043195	terminal bouton(GO:0043195)
0.3	37.4	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	32.7	GO:0005783	endoplasmic reticulum(GO:0005783)
0.3	26.3	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1	26.3	GO:0005743	mitochondrial inner membrane(GO:0005743)
5.0	24.8	GO:0005896	interleukin-6 receptor complex(GO:0005896)

Showing 1 to 10 of 72 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.9	129.0	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
14.5	58.0	GO:0004074	biliverdin reductase activity(GO:0004074)
1.3	51.7	GO:0008143	poly(A) binding(GO:0008143)
4.0	48.6	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.4	43.2	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1	41.8	GO:0003779	actin binding(GO:0003779)
0.1	38.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
2.2	37.6	GO:0001222	transcription corepressor binding(GO:0001222)
1.4	34.1	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.6	31.7	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)

Showing 1 to 10 of 114 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	31.6	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.5	27.5	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4	26.5	PID AURORA B PATHWAY	Aurora B signaling
0.7	25.1	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
1.3	24.8	ST STAT3 PATHWAY	STAT3 Pathway
0.4	22.8	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.1	22.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	15.7	PID IL12 2PATHWAY	IL12-mediated signaling events
0.3	14.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.3	14.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	61.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.9	44.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.5	37.6	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
2.0	37.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.2	34.4	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
1.9	34.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.5	29.3	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	28.7	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
1.6	27.9	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
1.7	22.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1

Showing 1 to 10 of 57 entries

Results for CEBPE_CEBPD

Z-value: 1.40

Motif logo

Transcription factors associated with CEBPE_CEBPD

Activity-expression correlation:

Activity profile of CEBPE_CEBPD motif

Sorted Z-values of CEBPE_CEBPD motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPE_CEBPD

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: