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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CENPB
Z-value: 0.87
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Transcription factors associated with CENPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CENPB | hg38_v1_chr20_-_3786677_3786797 | -0.54 | 1.3e-17 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CENPB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 96.7 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 5.3 | 21.1 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
| 0.1 | 20.9 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 17.7 | GO:0030518 | intracellular steroid hormone receptor signaling pathway(GO:0030518) |
| 0.3 | 14.5 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.9 | 14.0 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.2 | 13.2 | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) |
| 2.2 | 13.0 | GO:0021523 | somatic motor neuron differentiation(GO:0021523) |
| 4.0 | 11.9 | GO:1902363 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 3.9 | 11.7 | GO:2001226 | negative regulation of chloride transport(GO:2001226) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 85.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 28.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 23.3 | GO:0009986 | cell surface(GO:0009986) |
| 0.6 | 21.1 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.8 | 13.3 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.2 | 12.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 12.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 4.0 | 11.9 | GO:0061673 | cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673) |
| 0.4 | 11.5 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.3 | 11.4 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.7 | 96.7 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 40.3 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 22.9 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 5.3 | 21.1 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 4.2 | 20.9 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 17.7 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 17.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 14.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 13.3 | GO:0019905 | syntaxin binding(GO:0019905) |
| 1.2 | 11.9 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 11.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 9.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 8.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 8.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 7.7 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 4.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 4.3 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 4.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 4.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 22.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 21.1 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.9 | 11.9 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.6 | 11.7 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.3 | 11.4 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.3 | 9.7 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 8.6 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.4 | 7.3 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 7.3 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |