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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CGUACCG

Z-value: 0.13

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miRNA associated with seed CGUACCG

NamemiRBASE accession
hsa-miR-126-3p.1
MIMAT0000445

Activity profile of CGUACCG motif

Sorted Z-values of CGUACCG motif

Network of associatons between targets according to the STRING database.

Top targets:

Promoter Score Transcript Gene Gene Info
chr5_-_58460076 2.06 ENST00000274289.8
ENST00000617412.1
PLK2
polo like kinase 2
chr8_+_96493803 1.16 ENST00000518385.5
ENST00000302190.9
SDC2
syndecan 2
chr2_-_226799806 1.11 ENST00000305123.6
IRS1
insulin receptor substrate 1
chr8_+_38996899 0.86 ENST00000677582.1
ENST00000676643.1
ENST00000676936.1
ENST00000677004.1
ENST00000487273.7
ENST00000481513.5
ADAM9
ADAM metallopeptidase domain 9
chr1_+_15409858 0.61 ENST00000375980.9
EFHD2
EF-hand domain family member D2
chr16_+_56932134 0.60 ENST00000439977.7
ENST00000300302.9
ENST00000344114.8
ENST00000379792.6
HERPUD1
homocysteine inducible ER protein with ubiquitin like domain 1
chr1_-_89126066 0.38 ENST00000370466.4
GBP2
guanylate binding protein 2
chr15_+_85380565 0.30 ENST00000559362.5
ENST00000394518.7
AKAP13
A-kinase anchoring protein 13
chr17_-_1456149 0.24 ENST00000574295.1
ENST00000398970.5
ENST00000300574.3
CRK
CRK proto-oncogene, adaptor protein
chr10_-_689613 0.24 ENST00000280886.12
ENST00000634311.1
DIP2C
disco interacting protein 2 homolog C
chr9_+_136658854 0.14 ENST00000371699.5
EGFL7
EGF like domain multiple 7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0034239 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.2 1.2 GO:0008218 bioluminescence(GO:0008218)
0.1 2.1 GO:0061000 negative regulation of dendritic spine development(GO:0061000)
0.1 1.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.3 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.6 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.6 GO:1990037 Lewy body core(GO:1990037)
0.0 0.9 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 2.1 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 1.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.9 GO:0043236 laminin binding(GO:0043236)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID IGF1 PATHWAY IGF1 pathway
0.0 1.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4