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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CLOCK
Z-value: 1.83
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Transcription factors associated with CLOCK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CLOCK | hg38_v1_chr4_-_55546900_55546919 | 0.01 | 9.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CLOCK
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.8 | 153.8 | GO:1905098 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 27.8 | 139.0 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 7.6 | 122.4 | GO:0009113 | purine nucleobase biosynthetic process(GO:0009113) |
| 13.2 | 118.6 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 19.3 | 115.5 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 1.5 | 112.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 6.5 | 109.8 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 11.0 | 98.8 | GO:0031536 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536) |
| 32.3 | 96.9 | GO:0002368 | B cell cytokine production(GO:0002368) |
| 21.3 | 85.3 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 201.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 11.6 | 115.5 | GO:0070552 | BRISC complex(GO:0070552) |
| 18.8 | 112.8 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.2 | 109.4 | GO:0005874 | microtubule(GO:0005874) |
| 3.4 | 98.8 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 10.8 | 96.9 | GO:0046696 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 96.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 94.7 | GO:0005730 | nucleolus(GO:0005730) |
| 2.3 | 90.7 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.3 | 89.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 158.0 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.7 | 137.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 135.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.4 | 130.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 19.3 | 115.5 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 2.2 | 102.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 14.4 | 100.8 | GO:0004459 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 0.3 | 100.2 | GO:0015631 | tubulin binding(GO:0015631) |
| 16.1 | 96.9 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 1.6 | 80.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 436.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 7.8 | 155.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 3.8 | 72.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.3 | 62.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 58.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.5 | 52.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.8 | 49.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.9 | 47.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.3 | 38.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 25.5 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 204.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 8.8 | 177.0 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 6.9 | 103.5 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 3.8 | 98.8 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 2.6 | 85.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.9 | 74.5 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 2.0 | 72.4 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 1.7 | 68.4 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.6 | 62.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.6 | 52.7 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |