ISMARA results: CPEB1

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for CPEB1

Z-value: 1.09

Motif logo

Transcription factors associated with CPEB1

Gene Symbol	Gene ID	Gene Info
CPEB1 Ensembl NCBI GeneCards UniProt	ENSG00000214575.10	CPEB1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CPEB1	hg38_v1_chr15_-_82647336_82647386	-0.41	2.4e-10	Click!

Activity profile of CPEB1 motif

Sorted Z-values of CPEB1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CPEB1

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr14_+_55611977 Show fit	32.53	ENST00000395309.7 ENST00000413890.6	KTN1 Ensembl NCBI GeneCards UniProt Show fit	kinectin 1
chr12_-_53677397 Show fit	25.80	ENST00000338662.6 ENST00000552242.5	ATP5MC2 Ensembl NCBI GeneCards UniProt Show fit	ATP synthase membrane subunit c locus 2
chr2_-_150487658 Show fit	24.65	ENST00000375734.6 ENST00000263895.9 ENST00000454202.5	RND3 Ensembl NCBI GeneCards UniProt Show fit	Rho family GTPase 3
chr11_-_11353241 Show fit	19.68	ENST00000528848.3	CSNK2A3 Ensembl NCBI GeneCards UniProt Show fit	casein kinase 2 alpha 3
chr3_-_142028597 Show fit	19.22	ENST00000467667.5	TFDP2 Ensembl NCBI GeneCards UniProt Show fit	transcription factor Dp-2
chr17_+_47209375 Show fit	17.84	ENST00000572303.1	MYL4 Ensembl NCBI GeneCards UniProt Show fit	myosin light chain 4
chr1_-_92075441 Show fit	17.34	ENST00000596516.2	SETSIP Ensembl NCBI GeneCards UniProt Show fit	SET like protein
chr2_-_189179754 Show fit	15.79	ENST00000374866.9 ENST00000618828.1	COL5A2 Ensembl NCBI GeneCards UniProt Show fit	collagen type V alpha 2 chain
chr6_+_110874775 Show fit	15.41	ENST00000675380.1 ENST00000368882.8 ENST00000368877.9 ENST00000368885.8 ENST00000672937.2	AMD1 Ensembl NCBI GeneCards UniProt Show fit	adenosylmethionine decarboxylase 1
chr1_-_31919093 Show fit	15.02	ENST00000602683.5 ENST00000470404.5	PTP4A2 Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase 4A2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.3	47.0	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
3.5	46.1	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.9	36.7	GO:0002026	regulation of the force of heart contraction(GO:0002026)
0.7	27.0	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2	26.8	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1	25.3	GO:0007018	microtubule-based movement(GO:0007018)
1.7	25.0	GO:1903760	regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.4	24.0	GO:0031648	protein destabilization(GO:0031648)
1.6	21.0	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.6	20.7	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)

Showing 1 to 10 of 177 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	51.6	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.5	46.9	GO:0016459	myosin complex(GO:0016459)
1.8	44.7	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.2	36.6	GO:0031901	early endosome membrane(GO:0031901)
0.2	36.0	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.0	32.3	GO:0000139	Golgi membrane(GO:0000139)
1.2	27.2	GO:0035748	myelin sheath abaxonal region(GO:0035748)
0.1	23.2	GO:0005938	cell cortex(GO:0005938)
7.7	23.0	GO:0008623	CHRAC(GO:0008623)
0.1	21.2	GO:0005769	early endosome(GO:0005769)

Showing 1 to 10 of 86 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.1	46.1	GO:0008494	translation activator activity(GO:0008494)
1.9	42.0	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1	41.8	GO:0045296	cadherin binding(GO:0045296)
0.6	40.6	GO:0019894	kinesin binding(GO:0019894)
6.1	36.4	GO:0032038	myosin II heavy chain binding(GO:0032038)
3.1	28.2	GO:0004727	prenylated protein tyrosine phosphatase activity(GO:0004727)
1.3	23.1	GO:0097016	L27 domain binding(GO:0097016)
0.3	23.0	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.1	22.9	GO:0005525	GTP binding(GO:0005525)
1.6	21.0	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)

Showing 1 to 10 of 129 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	47.9	PID E2F PATHWAY	E2F transcription factor network
0.4	31.3	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.7	30.3	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.4	21.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.4	21.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.3	16.6	NABA COLLAGENS	Genes encoding collagen proteins
0.3	16.3	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	15.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	13.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.3	12.3	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway

Showing 1 to 10 of 40 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	43.9	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
2.6	42.0	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.1	39.8	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5	34.2	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	25.0	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.4	20.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
1.0	17.3	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.4	16.6	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.4	16.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.3	15.6	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis

Showing 1 to 10 of 61 entries

Results for CPEB1

Z-value: 1.09

Motif logo

Transcription factors associated with CPEB1

Activity-expression correlation:

Activity profile of CPEB1 motif

Sorted Z-values of CPEB1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CPEB1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: