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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CREB1
Z-value: 2.16
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Transcription factors associated with CREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB1 | hg38_v1_chr2_+_207529731_207529747 | 0.63 | 2.2e-25 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 60.0 | 179.9 | GO:0075732 | viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594) |
| 13.6 | 149.6 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.9 | 104.8 | GO:0071427 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 6.4 | 102.5 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 1.3 | 101.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.5 | 100.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 27.3 | 82.0 | GO:0034473 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 18.7 | 74.8 | GO:0006408 | snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833) |
| 2.5 | 74.7 | GO:0072663 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 21.4 | 64.2 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.0 | 238.1 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 9.9 | 128.3 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 24.0 | 120.1 | GO:0042025 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 14.6 | 102.5 | GO:0032021 | NELF complex(GO:0032021) |
| 2.5 | 101.0 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.6 | 100.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 18.7 | 74.8 | GO:0005846 | nuclear cap binding complex(GO:0005846) |
| 2.3 | 64.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 6.8 | 61.4 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 1.6 | 60.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 215.3 | GO:0043495 | protein anchor(GO:0043495) |
| 0.6 | 128.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 6.7 | 120.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 1.9 | 100.6 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 95.0 | GO:0003682 | chromatin binding(GO:0003682) |
| 4.3 | 82.0 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 7.5 | 74.8 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 1.1 | 63.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 20.1 | 60.2 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 14.4 | 57.5 | GO:0004802 | transketolase activity(GO:0004802) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 210.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.5 | 72.4 | PID E2F PATHWAY | E2F transcription factor network |
| 1.4 | 25.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.6 | 20.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 20.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 19.7 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.2 | 15.4 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.2 | 13.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 8.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 8.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.6 | 352.2 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 3.4 | 120.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 1.2 | 100.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 6.8 | 82.0 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 2.2 | 69.7 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.3 | 57.5 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.8 | 55.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.3 | 46.8 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.3 | 40.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.9 | 36.8 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |