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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CREB3L1_CREB3
Z-value: 1.31
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Transcription factors associated with CREB3L1_CREB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB3 | hg38_v1_chr9_+_35732649_35732685 | 0.23 | 5.8e-04 | Click! |
| CREB3L1 | hg38_v1_chr11_+_46277648_46277686 | 0.22 | 1.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB3L1_CREB3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 85.0 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 3.9 | 66.0 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.3 | 46.0 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 4.0 | 39.5 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 3.9 | 34.7 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.3 | 29.0 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 1.4 | 25.4 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.3 | 22.4 | GO:0031529 | ruffle organization(GO:0031529) |
| 2.8 | 16.8 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 5.5 | 16.5 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 88.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 4.4 | 43.9 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 38.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 38.6 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.4 | 37.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.2 | 36.0 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 5.4 | 32.3 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.1 | 31.0 | GO:0043197 | dendritic spine(GO:0043197) |
| 1.0 | 23.0 | GO:0042599 | lamellar body(GO:0042599) |
| 0.3 | 22.1 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.0 | 52.0 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 0.0 | 37.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 37.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 29.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 5.1 | 25.4 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 3.6 | 21.6 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 21.4 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 20.1 | GO:0003723 | RNA binding(GO:0003723) |
| 0.4 | 18.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 6.0 | 18.0 | GO:0005046 | KDEL sequence binding(GO:0005046) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 41.1 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 25.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 22.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.3 | 20.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.5 | 18.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 17.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 16.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 12.9 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.4 | 11.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.2 | 10.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 78.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.6 | 45.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 41.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 16.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.8 | 16.5 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 1.5 | 16.2 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.2 | 14.7 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.9 | 14.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.5 | 11.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.6 | 11.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |