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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CTCF_CTCFL
Z-value: 0.91
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Transcription factors associated with CTCF_CTCFL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CTCFL | hg38_v1_chr20_-_57525097_57525108 | -0.40 | 1.3e-09 | Click! |
| CTCF | hg38_v1_chr16_+_67562514_67562594 | 0.37 | 2.8e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CTCF_CTCFL
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 50.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 35.5 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 3.9 | 34.8 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.4 | 32.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.7 | 32.2 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.1 | 23.9 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.3 | 22.9 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 4.2 | 21.0 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 0.3 | 20.7 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 3.1 | 18.8 | GO:1904688 | regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 51.9 | GO:0008274 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.4 | 46.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.1 | 44.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 33.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.0 | 28.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 2.7 | 26.9 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.2 | 25.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.5 | 23.7 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 21.1 | GO:0005840 | ribosome(GO:0005840) |
| 1.9 | 21.0 | GO:0030870 | Mre11 complex(GO:0030870) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 79.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 31.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.6 | 28.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.6 | 28.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 25.3 | GO:0043175 | RNA polymerase core enzyme binding(GO:0043175) |
| 2.1 | 21.1 | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242) |
| 0.5 | 20.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 3.0 | 18.1 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 1.4 | 18.0 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.0 | 17.1 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 17.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 15.6 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 15.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 14.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.3 | 11.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.2 | 10.4 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.4 | 9.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 9.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 8.9 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 37.8 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.4 | 37.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.3 | 34.1 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.5 | 34.0 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 1.3 | 28.9 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.4 | 28.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.8 | 24.1 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.7 | 23.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 22.0 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 19.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |