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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CUUUGGU
Z-value: 1.43
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miRNA associated with seed CUUUGGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-9-5p
|
MIMAT0000441 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUUUGGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.6 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 1.1 | 27.0 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 1.3 | 26.2 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.2 | 24.7 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.2 | 24.5 | GO:0030509 | BMP signaling pathway(GO:0030509) |
| 0.7 | 22.6 | GO:0071800 | podosome assembly(GO:0071800) |
| 4.5 | 22.4 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 3.1 | 21.9 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.2 | 21.2 | GO:0042035 | regulation of cytokine biosynthetic process(GO:0042035) |
| 1.5 | 20.9 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 63.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 54.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 50.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 43.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 35.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.6 | 33.7 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 32.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 2.7 | 29.3 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 0.0 | 26.8 | GO:0005615 | extracellular space(GO:0005615) |
| 2.5 | 24.8 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 35.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 32.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.4 | 32.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.4 | 29.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 24.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 22.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 3.1 | 21.9 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.5 | 20.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 20.1 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 69.8 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 36.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 33.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.6 | 29.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.8 | 29.3 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 28.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 26.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 25.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 25.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 22.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 31.4 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.4 | 29.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 1.1 | 28.5 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 1.7 | 28.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.6 | 26.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.9 | 23.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.4 | 21.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.7 | 21.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.7 | 19.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 19.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |