ISMARA results: CUX1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CUX1

Z-value: 1.68

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Transcription factors associated with CUX1

Gene Symbol	Gene ID	Gene Info
CUX1 Ensembl NCBI GeneCards UniProt	ENSG00000257923.12	CUX1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CUX1	hg38_v1_chr7_+_101815983_101816030	0.34	2.0e-07	Click!

Activity profile of CUX1 motif

Sorted Z-values of CUX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

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Promoter	Score	Transcript	Gene	Gene Info
chr11_-_5227063 Show fit	45.11	ENST00000335295.4 ENST00000485743.1 ENST00000647020.1	HBB Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit beta
chr14_-_105626066 Show fit	35.82	ENST00000641978.1 ENST00000390543.3	IGHG4 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy constant gamma 4 (G4m marker)
chr6_-_32589833 Show fit	28.52	ENST00000360004.5	HLA-DRB1 Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DR beta 1
chr9_+_71911468 Show fit	25.21	ENST00000377031.7	C9orf85 Ensembl NCBI GeneCards UniProt Show fit	chromosome 9 open reading frame 85
chr12_-_9115907 Show fit	23.86	ENST00000318602.12	A2M Ensembl NCBI GeneCards UniProt Show fit	alpha-2-macroglobulin
chr1_+_152675295 Show fit	21.61	ENST00000368783.1	LCE2C Ensembl NCBI GeneCards UniProt Show fit	late cornified envelope 2C
chr10_-_118595637 Show fit	19.70	ENST00000239032.4	PRLHR Ensembl NCBI GeneCards UniProt Show fit	prolactin releasing hormone receptor
chr12_-_91180365 Show fit	19.45	ENST00000547937.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr17_+_1762052 Show fit	19.40	ENST00000254722.9 ENST00000576406.5 ENST00000571149.5	SERPINF1 Ensembl NCBI GeneCards UniProt Show fit	serpin family F member 1
chr5_-_150155828 Show fit	18.54	ENST00000261799.9	PDGFRB Ensembl NCBI GeneCards UniProt Show fit	platelet derived growth factor receptor beta

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	84.5	GO:0006910	phagocytosis, recognition(GO:0006910)
0.6	51.7	GO:0006958	complement activation, classical pathway(GO:0006958)
0.3	51.1	GO:0002377	immunoglobulin production(GO:0002377)
16.6	49.8	GO:0001868	regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
15.0	45.1	GO:0030185	nitric oxide transport(GO:0030185)
1.0	44.3	GO:0019731	antibacterial humoral response(GO:0019731)
0.5	43.0	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.5	42.4	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.4	37.4	GO:0032945	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
2.2	36.7	GO:0090360	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)

Showing 1 to 10 of 323 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	167.9	GO:0005615	extracellular space(GO:0005615)
1.7	84.5	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.5	58.6	GO:0042734	presynaptic membrane(GO:0042734)
0.3	51.1	GO:0030426	growth cone(GO:0030426)
11.3	45.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.4	43.9	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	41.7	GO:0016323	basolateral plasma membrane(GO:0016323)
0.2	39.8	GO:0009897	external side of plasma membrane(GO:0009897)
1.7	32.0	GO:0042613	MHC class II protein complex(GO:0042613)
0.4	30.1	GO:0043195	terminal bouton(GO:0043195)

Showing 1 to 10 of 140 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	158.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.5	89.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.6	61.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.3	47.9	GO:0017137	Rab GTPase binding(GO:0017137)
6.4	45.1	GO:0030492	hemoglobin binding(GO:0030492)
0.4	36.1	GO:0098531	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
2.3	35.1	GO:0019957	C-C chemokine binding(GO:0019957)
6.8	33.9	GO:0004522	ribonuclease A activity(GO:0004522)
1.8	32.9	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.5	31.1	GO:0030507	spectrin binding(GO:0030507)

Showing 1 to 10 of 237 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	76.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.3	74.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	62.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	62.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	34.4	PID EPHB FWD PATHWAY	EPHB forward signaling
0.4	25.6	PID BMP PATHWAY	BMP receptor signaling
0.4	21.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.1	19.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.8	16.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	16.9	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription

Showing 1 to 10 of 66 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	54.2	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
2.1	49.4	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.7	45.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.1	37.9	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.3	36.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	28.4	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
1.0	27.8	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
1.6	26.4	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.5	25.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.6	25.5	REACTOME AMYLOIDS	Genes involved in Amyloids

Showing 1 to 10 of 98 entries

Results for CUX1

Z-value: 1.68

Motif logo

Transcription factors associated with CUX1

Activity-expression correlation:

Activity profile of CUX1 motif

Sorted Z-values of CUX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: