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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CUX2
Z-value: 1.17
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Transcription factors associated with CUX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CUX2 | hg38_v1_chr12_+_111034136_111034173 | 0.35 | 7.9e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 44.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 3.9 | 35.4 | GO:2000332 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.5 | 27.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 26.6 | GO:0050808 | synapse organization(GO:0050808) |
| 4.8 | 23.8 | GO:1902952 | NMDA glutamate receptor clustering(GO:0097114) positive regulation of postsynaptic membrane organization(GO:1901628) positive regulation of dendritic spine maintenance(GO:1902952) |
| 1.6 | 23.0 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.4 | 22.8 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 1.7 | 22.6 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 1.3 | 19.8 | GO:2000394 | positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 0.3 | 18.8 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 110.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 81.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 77.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 3.4 | 44.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.0 | 38.2 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 5.9 | 23.8 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.2 | 23.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.3 | 21.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 20.2 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.2 | 19.3 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 45.4 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.5 | 43.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 4.4 | 35.4 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.4 | 23.9 | GO:0004601 | peroxidase activity(GO:0004601) |
| 5.9 | 23.8 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 2.3 | 23.4 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.7 | 21.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 20.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 4.9 | 19.8 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 19.7 | GO:0030246 | carbohydrate binding(GO:0030246) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 60.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 42.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 34.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 26.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 20.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 19.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 15.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 15.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.2 | 13.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 11.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 47.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 1.6 | 44.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 38.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.3 | 27.4 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 1.7 | 27.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.8 | 19.6 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.3 | 18.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.8 | 18.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 16.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.3 | 15.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |