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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CXXC1
Z-value: 1.87
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Transcription factors associated with CXXC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CXXC1 | hg38_v1_chr18_-_50287570_50287709 | 0.22 | 8.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CXXC1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_138404206 Show fit | 49.57 |
ENST00000607197.6
ENST00000367697.7 |
heme binding protein 2 |
|
| chr4_-_173334385 Show fit | 40.70 |
ENST00000446922.6
|
high mobility group box 2 |
|
| chr4_-_173334249 Show fit | 36.39 |
ENST00000506267.1
ENST00000296503.10 |
high mobility group box 2 |
|
| chr8_-_80029904 Show fit | 35.35 |
ENST00000521434.5
ENST00000519120.1 ENST00000520946.1 |
mitochondrial ribosomal protein S28 |
|
| chr4_-_173333672 Show fit | 34.86 |
ENST00000438704.6
|
high mobility group box 2 |
|
| chr1_+_40258202 Show fit | 33.52 |
ENST00000372759.4
|
zinc metallopeptidase STE24 |
|
| chr5_+_96662969 Show fit | 33.04 |
ENST00000514845.5
ENST00000675663.1 |
calpastatin |
|
| chr18_+_657637 Show fit | 32.06 |
ENST00000323274.15
|
thymidylate synthetase |
|
| chr8_-_80030232 Show fit | 31.89 |
ENST00000518271.1
ENST00000276585.9 ENST00000521605.1 |
mitochondrial ribosomal protein S28 |
|
| chr3_-_185923893 Show fit | 30.33 |
ENST00000259043.11
|
transformer 2 beta homolog |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 202.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.0 | 130.5 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 9.3 | 112.0 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 1.1 | 102.4 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 2.5 | 81.3 | GO:0007094 | mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173) |
| 0.4 | 76.4 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 3.2 | 63.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 2.2 | 57.8 | GO:0097341 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 1.6 | 52.7 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 8.3 | 49.7 | GO:0006235 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 153.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 1.3 | 140.2 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 4.8 | 133.7 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.3 | 113.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.7 | 86.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.7 | 62.3 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.6 | 60.0 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 1.3 | 52.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.4 | 51.6 | GO:0030496 | midbody(GO:0030496) |
| 2.9 | 49.9 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 217.8 | GO:0003723 | RNA binding(GO:0003723) |
| 0.9 | 193.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 28.0 | 112.0 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 0.6 | 71.6 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 5.8 | 57.8 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 1.8 | 52.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.9 | 52.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 3.8 | 49.9 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 7.0 | 48.9 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 1.3 | 47.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 150.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.6 | 105.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.6 | 70.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.8 | 57.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.7 | 56.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.1 | 53.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 1.0 | 46.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.5 | 45.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.1 | 44.1 | PID MYC PATHWAY | C-MYC pathway |
| 1.0 | 43.3 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 210.1 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.1 | 123.6 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 7.4 | 111.6 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 1.2 | 92.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.6 | 90.7 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 2.1 | 81.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.9 | 79.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.0 | 71.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.3 | 71.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.1 | 65.7 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |