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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DBP
Z-value: 0.73
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Transcription factors associated with DBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DBP | hg38_v1_chr19_-_48634526_48634636 | 0.25 | 1.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DBP
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_2324642 Show fit | 12.89 |
ENST00000650485.1
ENST00000649207.1 |
myelin transcription factor 1 like |
|
| chr4_-_175812746 Show fit | 12.50 |
ENST00000393658.6
|
glycoprotein M6A |
|
| chr2_-_2324323 Show fit | 10.03 |
ENST00000648339.1
ENST00000647694.1 |
myelin transcription factor 1 like |
|
| chr16_+_7332839 Show fit | 8.80 |
ENST00000355637.9
|
RNA binding fox-1 homolog 1 |
|
| chr8_+_84705920 Show fit | 7.85 |
ENST00000523850.5
ENST00000521376.1 |
RALY RNA binding protein like |
|
| chr11_+_121590388 Show fit | 7.70 |
ENST00000527934.1
|
sortilin related receptor 1 |
|
| chr4_-_56681288 Show fit | 7.02 |
ENST00000556376.6
ENST00000420433.6 |
HOP homeobox |
|
| chr8_-_109680812 Show fit | 6.69 |
ENST00000528716.5
ENST00000527600.5 ENST00000531230.5 ENST00000532189.5 ENST00000534184.5 ENST00000408889.7 ENST00000533171.5 |
syntabulin |
|
| chr6_-_31546552 Show fit | 6.51 |
ENST00000303892.10
ENST00000376151.4 |
ATPase H+ transporting V1 subunit G2 |
|
| chr11_-_31811140 Show fit | 6.30 |
ENST00000639916.1
|
paired box 6 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 40.9 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.6 | 22.8 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.2 | 15.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 1.3 | 13.2 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.3 | 11.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.2 | 11.3 | GO:0043278 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.3 | 10.8 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.3 | 9.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.6 | 8.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 2.6 | 7.7 | GO:1905246 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.3 | 17.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 17.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 16.3 | GO:0005694 | chromosome(GO:0005694) |
| 0.2 | 13.2 | GO:0031430 | M band(GO:0031430) |
| 0.5 | 12.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 10.3 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.4 | 8.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 7.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 6.9 | GO:0071565 | nBAF complex(GO:0071565) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 41.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 28.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.8 | 13.3 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 12.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.5 | 11.9 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 10.7 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.6 | 8.9 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.7 | 8.8 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.5 | 7.7 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.2 | 7.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 40.2 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.5 | 14.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 11.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 8.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 6.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.3 | 6.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 4.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 2.4 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 2.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.0 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 40.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.3 | 14.0 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.4 | 10.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 8.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 8.0 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 6.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 6.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.3 | 6.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 5.6 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 4.9 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |