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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DBX2_HLX
Z-value: 0.64
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Transcription factors associated with DBX2_HLX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HLX | hg38_v1_chr1_+_220879434_220879457 | -0.03 | 6.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DBX2_HLX
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_138621225 Show fit | 13.94 |
ENST00000479848.1
|
Fas apoptotic inhibitory molecule |
|
| chr14_+_34993240 Show fit | 13.32 |
ENST00000677647.1
|
signal recognition particle 54 |
|
| chr1_-_45522870 Show fit | 11.20 |
ENST00000424390.2
|
peroxiredoxin 1 |
|
| chr3_+_138621207 Show fit | 11.18 |
ENST00000464668.5
|
Fas apoptotic inhibitory molecule |
|
| chr4_+_112647059 Show fit | 10.67 |
ENST00000511529.1
|
La ribonucleoprotein 7, transcriptional regulator |
|
| chr1_+_81306096 Show fit | 10.24 |
ENST00000370721.5
ENST00000370727.5 ENST00000370725.5 ENST00000370723.5 ENST00000370728.5 ENST00000370730.5 |
adhesion G protein-coupled receptor L2 |
|
| chr14_+_61697622 Show fit | 8.69 |
ENST00000539097.2
|
hypoxia inducible factor 1 subunit alpha |
|
| chr7_+_130486324 Show fit | 7.75 |
ENST00000427521.6
ENST00000378576.9 |
mesoderm specific transcript |
|
| chr7_+_130486171 Show fit | 7.42 |
ENST00000341441.9
ENST00000416162.7 |
mesoderm specific transcript |
|
| chr3_-_64019334 Show fit | 7.37 |
ENST00000480205.5
|
proteasome 26S subunit, non-ATPase 6 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.7 | GO:0043066 | negative regulation of apoptotic process(GO:0043066) |
| 0.3 | 14.2 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.1 | 14.1 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.3 | 13.4 | GO:0071451 | cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) |
| 3.3 | 13.3 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.1 | 12.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.6 | 11.0 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 1.5 | 10.4 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.1 | 10.3 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.2 | 9.3 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.8 | GO:0005911 | cell-cell junction(GO:0005911) |
| 1.5 | 13.3 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.1 | 12.0 | GO:0005901 | caveola(GO:0005901) |
| 1.6 | 11.0 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.8 | 9.0 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 9.0 | GO:0030529 | intracellular ribonucleoprotein complex(GO:0030529) |
| 0.1 | 8.7 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.8 | 8.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.3 | 7.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 7.5 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 13.3 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.2 | 12.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 1.4 | 11.2 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 2.6 | 10.2 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.3 | 10.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 9.6 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.4 | 9.2 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 8.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 8.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.9 | 8.2 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 13.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 11.2 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.7 | 9.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.3 | 8.7 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 8.5 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 8.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 7.7 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 6.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 6.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.5 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 17.6 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.9 | 14.9 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.4 | 13.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 11.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 10.8 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 9.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.8 | 9.0 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 8.6 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 7.0 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |