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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DDIT3
Z-value: 0.59
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Transcription factors associated with DDIT3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DDIT3 | hg38_v1_chr12_-_57520480_57520521 | -0.24 | 3.8e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DDIT3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 19.6 | GO:0030497 | fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761) |
| 5.9 | 17.6 | GO:0008615 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819) |
| 1.7 | 13.2 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 1.5 | 11.9 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 0.0 | 11.9 | GO:0051017 | actin filament bundle assembly(GO:0051017) |
| 1.0 | 11.2 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.2 | 9.3 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 2.8 | 8.5 | GO:1903015 | regulation of exo-alpha-sialidase activity(GO:1903015) |
| 0.5 | 8.2 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 1.3 | 7.5 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 13.2 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 10.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 2.3 | 9.3 | GO:0071942 | XPC complex(GO:0071942) |
| 0.1 | 8.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.5 | 8.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 7.9 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.4 | 7.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.2 | 7.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 7.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 19.6 | GO:0080023 | 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023) |
| 0.7 | 19.1 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.2 | 13.2 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 2.0 | 11.9 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 2.2 | 11.2 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.0 | 11.2 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.2 | 9.3 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 1.2 | 8.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.7 | 8.2 | GO:0046790 | virion binding(GO:0046790) |
| 0.2 | 7.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 8.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 7.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 7.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 3.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 2.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 35.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 11.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.3 | 9.3 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 8.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.6 | 8.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.3 | 8.2 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.4 | 7.5 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 4.7 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 4.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 4.1 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |