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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DLX1_HOXA3_BARX2
Z-value: 0.79
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Transcription factors associated with DLX1_HOXA3_BARX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARX2 | hg38_v1_chr11_+_129375841_129375863 | 0.26 | 1.2e-04 | Click! |
| HOXA3 | hg38_v1_chr7_-_27140195_27140221 | 0.24 | 3.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX1_HOXA3_BARX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.2 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.3 | 26.9 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 2.2 | 22.1 | GO:0006537 | glutamate biosynthetic process(GO:0006537) |
| 0.2 | 20.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 18.7 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 15.3 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.2 | 14.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 1.2 | 14.5 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 4.7 | 14.0 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.3 | 12.6 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 63.1 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.1 | 35.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 17.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 13.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 1.8 | 12.9 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 11.0 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.3 | 10.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 7.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 7.0 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 6.9 | GO:0043034 | costamere(GO:0043034) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 26.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 1.9 | 26.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.6 | 23.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.2 | 17.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 13.3 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 2.6 | 12.9 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 1.2 | 11.7 | GO:0004064 | arylesterase activity(GO:0004064) |
| 1.9 | 11.3 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.1 | 10.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 14.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 10.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 9.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 6.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 6.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.2 | 4.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 4.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.1 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 4.0 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.1 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 17.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.8 | 12.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.5 | 11.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 10.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.4 | 8.6 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.5 | 7.7 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 7.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 6.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 5.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |