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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DLX3_EVX1_MEOX1
Z-value: 0.74
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Transcription factors associated with DLX3_EVX1_MEOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEOX1 | hg38_v1_chr17_-_43661915_43661929 | -0.46 | 7.7e-13 | Click! |
| EVX1 | hg38_v1_chr7_+_27242796_27242807 | -0.44 | 6.4e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX3_EVX1_MEOX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 31.4 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.4 | 16.4 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 15.8 | GO:0007417 | central nervous system development(GO:0007417) |
| 1.7 | 14.9 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.2 | 14.4 | GO:0008542 | visual learning(GO:0008542) |
| 1.1 | 12.6 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.4 | 11.8 | GO:0034063 | stress granule assembly(GO:0034063) |
| 2.8 | 11.3 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 0.1 | 10.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 1.6 | 9.3 | GO:0042997 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.8 | 23.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 17.0 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 14.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.3 | 12.8 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 12.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 12.6 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 12.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 11.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 11.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.2 | 31.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 2.5 | 17.2 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.4 | 16.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.7 | 14.9 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.7 | 12.6 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 1.1 | 11.8 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.8 | 11.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.6 | 9.5 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.3 | 9.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 13.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 11.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.3 | 10.6 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 7.5 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 7.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 6.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 6.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 5.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 5.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 31.4 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.6 | 17.2 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.9 | 14.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.6 | 11.3 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 9.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.3 | 9.3 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 6.9 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 5.9 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 5.9 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 5.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |