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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DLX4_HOXD8
Z-value: 0.93
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Transcription factors associated with DLX4_HOXD8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DLX4 | hg38_v1_chr17_+_49969178_49969214 | 0.15 | 2.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX4_HOXD8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_90038848 Show fit | 25.96 |
ENST00000390270.2
|
immunoglobulin kappa variable 3D-20 |
|
| chr2_+_90100235 Show fit | 20.63 |
ENST00000492446.1
|
immunoglobulin kappa variable 1D-16 |
|
| chr2_-_89100352 Show fit | 18.13 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr8_-_85341705 Show fit | 17.39 |
ENST00000517618.5
|
carbonic anhydrase 1 |
|
| chr2_+_90172802 Show fit | 15.77 |
ENST00000390277.3
|
immunoglobulin kappa variable 3D-11 |
|
| chr2_+_90209873 Show fit | 15.71 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr7_+_142791635 Show fit | 13.92 |
ENST00000633705.1
|
T cell receptor beta constant 1 |
|
| chr2_+_90159840 Show fit | 13.40 |
ENST00000377032.5
|
immunoglobulin kappa variable 1D-12 |
|
| chr2_-_88979016 Show fit | 12.47 |
ENST00000390247.2
|
immunoglobulin kappa variable 3-7 (non-functional) |
|
| chr2_-_89117844 Show fit | 12.40 |
ENST00000490686.1
|
immunoglobulin kappa variable 1-17 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 272.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.6 | 107.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.5 | 31.0 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.2 | 16.1 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 5.0 | 15.0 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.5 | 14.9 | GO:0050869 | negative regulation of B cell activation(GO:0050869) |
| 0.1 | 14.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 3.1 | 12.3 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.7 | 12.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 3.7 | 11.0 | GO:0071461 | cellular response to redox state(GO:0071461) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 101.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 94.8 | GO:0005615 | extracellular space(GO:0005615) |
| 1.7 | 86.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 29.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.2 | 23.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 4.0 | 12.0 | GO:0071756 | IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756) |
| 0.2 | 11.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.3 | 11.3 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.3 | 10.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.9 | 10.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 378.1 | GO:0003823 | antigen binding(GO:0003823) |
| 3.0 | 30.0 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 29.4 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 15.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 14.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.7 | 13.4 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 1.3 | 13.0 | GO:0005549 | odorant binding(GO:0005549) |
| 0.9 | 12.8 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 3.1 | 12.3 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.7 | 12.2 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 42.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 22.8 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.2 | 15.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 14.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 13.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.2 | 8.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.3 | 6.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 6.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.9 | 30.5 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 25.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 15.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 13.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 12.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.2 | 12.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.5 | 11.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.5 | 11.0 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 1.7 | 10.5 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |