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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DLX5
Z-value: 0.39
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Transcription factors associated with DLX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DLX5 | hg38_v1_chr7_-_97024821_97024950 | -0.09 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_73988179 Show fit | 7.87 |
ENST00000296028.4
|
pro-platelet basic protein |
|
| chr6_+_106360668 Show fit | 6.59 |
ENST00000633556.3
|
crystallin beta-gamma domain containing 1 |
|
| chr19_+_49513353 Show fit | 3.13 |
ENST00000596975.5
|
Fc fragment of IgG receptor and transporter |
|
| chr11_-_33892010 Show fit | 2.80 |
ENST00000257818.3
|
LIM domain only 2 |
|
| chr18_-_61892997 Show fit | 2.72 |
ENST00000312828.4
|
ring finger protein 152 |
|
| chr7_-_87220567 Show fit | 2.67 |
ENST00000433078.5
|
transmembrane protein 243 |
|
| chr12_+_51424802 Show fit | 2.56 |
ENST00000453097.7
|
solute carrier family 4 member 8 |
|
| chr18_-_55587335 Show fit | 2.50 |
ENST00000638154.3
|
transcription factor 4 |
|
| chrX_+_101390824 Show fit | 2.45 |
ENST00000427805.6
ENST00000614077.4 |
ribosomal protein L36a |
|
| chr3_+_158801926 Show fit | 2.33 |
ENST00000622669.4
ENST00000392813.8 ENST00000415822.8 ENST00000651862.1 ENST00000264266.12 |
major facilitator superfamily domain containing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.9 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.1 | 5.7 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.0 | 3.1 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.1 | 2.8 | GO:0042789 | mRNA transcription from RNA polymerase II promoter(GO:0042789) |
| 0.0 | 2.8 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.2 | 2.7 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 2.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.6 | 1.9 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
| 0.6 | 1.8 | GO:0001300 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.1 | 1.8 | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 5.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 4.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 3.1 | GO:0031301 | integral component of organelle membrane(GO:0031301) |
| 0.0 | 2.8 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 2.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 1.8 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.6 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 6.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 5.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 4.3 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.8 | 3.1 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.1 | 2.8 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 2.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 1.9 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.0 | 1.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.6 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.5 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.8 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 5.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 3.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 1.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 1.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 1.0 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.0 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |