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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DMBX1
Z-value: 0.39
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Transcription factors associated with DMBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DMBX1 | hg38_v1_chr1_+_46489800_46489842 | 0.29 | 1.0e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DMBX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_174846405 Show fit | 7.66 |
ENST00000409597.5
ENST00000413882.6 |
chimerin 1 |
|
| chr5_+_72107453 Show fit | 3.27 |
ENST00000296755.12
ENST00000511641.2 |
microtubule associated protein 1B |
|
| chr9_-_21995301 Show fit | 3.25 |
ENST00000498628.6
|
cyclin dependent kinase inhibitor 2A |
|
| chr8_-_109644766 Show fit | 3.06 |
ENST00000533065.5
ENST00000276646.14 |
syntabulin |
|
| chr14_-_21022817 Show fit | 2.90 |
ENST00000554104.5
|
NDRG family member 2 |
|
| chr9_-_21995262 Show fit | 2.90 |
ENST00000494262.5
|
cyclin dependent kinase inhibitor 2A |
|
| chr17_-_19748285 Show fit | 2.89 |
ENST00000570414.1
ENST00000225740.11 |
aldehyde dehydrogenase 3 family member A1 |
|
| chr17_-_19748341 Show fit | 2.88 |
ENST00000395555.7
|
aldehyde dehydrogenase 3 family member A1 |
|
| chr17_-_19748355 Show fit | 2.47 |
ENST00000494157.6
|
aldehyde dehydrogenase 3 family member A1 |
|
| chr20_+_35968566 Show fit | 2.41 |
ENST00000373973.7
ENST00000349339.5 ENST00000489667.1 ENST00000538900.1 |
cyclic nucleotide binding domain containing 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 1.1 | 7.7 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 0.2 | 7.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.2 | 3.3 | GO:0061162 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.0 | 3.1 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.2 | 2.9 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.0 | 2.3 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 1.9 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.1 | 1.7 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.5 | 1.6 | GO:1902948 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 7.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 3.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.2 | 3.1 | GO:0097433 | dense body(GO:0097433) |
| 0.2 | 1.9 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 1.6 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 1.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.7 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.1 | 0.6 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.6 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.0 | 0.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 8.2 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.5 | 7.7 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.2 | 7.3 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 3.4 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 3.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 3.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 2.4 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 2.3 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.1 | 1.7 | GO:0004812 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.1 | 1.6 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 7.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 2.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.2 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.0 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 7.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.2 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 1.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 0.9 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 0.7 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |