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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DRGX_PROP1
Z-value: 0.46
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Transcription factors associated with DRGX_PROP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PROP1 | hg38_v1_chr5_-_177996242_177996242 | -0.23 | 5.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DRGX_PROP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_34236865 Show fit | 9.28 |
ENST00000674029.1
ENST00000447654.5 ENST00000347617.10 ENST00000401473.7 ENST00000311487.9 |
high mobility group AT-hook 1 |
|
| chrX_+_120604199 Show fit | 7.86 |
ENST00000371315.3
|
MCTS1 re-initiation and release factor |
|
| chr8_+_26293112 Show fit | 7.22 |
ENST00000523925.5
ENST00000315985.7 |
protein phosphatase 2 regulatory subunit Balpha |
|
| chr6_-_41071825 Show fit | 7.10 |
ENST00000468811.5
|
O-acyl-ADP-ribose deacylase 1 |
|
| chr11_-_11353241 Show fit | 7.00 |
ENST00000528848.3
|
casein kinase 2 alpha 3 |
|
| chrX_+_120604084 Show fit | 6.78 |
ENST00000371317.10
|
MCTS1 re-initiation and release factor |
|
| chr17_+_44957907 Show fit | 6.58 |
ENST00000678938.1
|
N-myristoyltransferase 1 |
|
| chr3_+_138621225 Show fit | 5.78 |
ENST00000479848.1
|
Fas apoptotic inhibitory molecule |
|
| chr11_+_108116688 Show fit | 5.68 |
ENST00000672284.1
|
acetyl-CoA acetyltransferase 1 |
|
| chr12_-_119804472 Show fit | 5.48 |
ENST00000678087.1
ENST00000677993.1 |
citron rho-interacting serine/threonine kinase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 14.6 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.2 | 10.5 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 3.1 | 9.3 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.3 | 7.2 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 7.1 | GO:0042278 | purine nucleoside metabolic process(GO:0042278) |
| 1.6 | 6.6 | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201) |
| 0.0 | 6.5 | GO:0030307 | positive regulation of cell growth(GO:0030307) |
| 1.9 | 5.7 | GO:0072019 | proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 1.4 | 5.4 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.2 | 4.8 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 10.8 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 1.3 | 9.3 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.2 | 7.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 6.0 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 5.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 4.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 4.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.2 | 3.8 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 3.3 | GO:0005875 | microtubule associated complex(GO:0005875) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.4 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.1 | 8.8 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.6 | 7.3 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.3 | 7.2 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 7.1 | GO:0019213 | deacetylase activity(GO:0019213) |
| 1.6 | 6.6 | GO:0019107 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 1.4 | 5.7 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 1.4 | 5.4 | GO:0035276 | aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276) |
| 0.2 | 4.6 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 4.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 10.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 9.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 9.2 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 7.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 5.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 2.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.5 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.3 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.4 | 7.8 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 7.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 6.6 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.2 | 5.7 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.5 | 5.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 3.1 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.2 | 3.0 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 2.7 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.2 | 2.5 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |