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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for E2F2_E2F5

Z-value: 2.86

Motif logo

Transcription factors associated with E2F2_E2F5

Gene Symbol Gene ID Gene Info
ENSG00000007968.7 E2F2
ENSG00000133740.11 E2F5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F2hg38_v1_chr1_-_23531206_23531241-0.449.7e-12Click!
E2F5hg38_v1_chr8_+_85187650_851876850.414.6e-10Click!

Activity profile of E2F2_E2F5 motif

Sorted Z-values of E2F2_E2F5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_+_10123171 204.86 ENST00000615152.5
ribonucleotide reductase regulatory subunit M2
chr2_-_135876382 124.17 ENST00000264156.3
minichromosome maintenance complex component 6
chr10_+_60778331 123.61 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
cyclin dependent kinase 1
chr7_-_100101333 117.20 ENST00000303887.10
minichromosome maintenance complex component 7
chr10_+_60778490 116.06 ENST00000448257.6
ENST00000614696.4
cyclin dependent kinase 1
chr15_-_64381431 105.89 ENST00000558008.3
ENST00000300035.9
ENST00000559519.5
ENST00000380258.6
PCNA clamp associated factor
chr6_+_24775413 99.37 ENST00000378054.6
ENST00000620958.4
ENST00000476555.5
geminin DNA replication inhibitor
chr6_-_52284677 96.97 ENST00000596288.7
ENST00000616552.4
ENST00000229854.12
ENST00000419835.8
minichromosome maintenance complex component 3
chr6_+_24774925 94.43 ENST00000356509.7
ENST00000230056.8
geminin DNA replication inhibitor
chr20_+_25407657 93.15 ENST00000262460.5
GINS complex subunit 1
chr3_+_127598400 89.50 ENST00000265056.12
minichromosome maintenance complex component 2
chr1_-_25906457 85.49 ENST00000426559.6
stathmin 1
chr19_-_10194898 84.83 ENST00000359526.9
ENST00000679103.1
ENST00000676610.1
ENST00000678804.1
ENST00000679313.1
ENST00000677946.1
DNA methyltransferase 1
chr8_-_123396412 81.93 ENST00000287394.10
ATPase family AAA domain containing 2
chr10_-_73247241 79.09 ENST00000372950.6
DnaJ heat shock protein family (Hsp40) member C9
chr7_+_26201705 75.02 ENST00000396386.7
ENST00000456948.5
ENST00000409747.5
chromobox 3
chr2_+_10122730 72.63 ENST00000304567.10
ribonucleotide reductase regulatory subunit M2
chr7_-_100101915 72.61 ENST00000621318.4
ENST00000343023.10
minichromosome maintenance complex component 7
chr6_-_18264475 71.75 ENST00000515742.2
ENST00000651624.1
ENST00000507591.2
ENST00000652689.1
ENST00000244776.11
ENST00000503715.5
DEK proto-oncogene
chr5_-_80654956 55.69 ENST00000439211.7
dihydrofolate reductase
chr5_-_80654552 55.61 ENST00000511032.5
ENST00000504396.1
ENST00000505337.5
dihydrofolate reductase
chr11_+_65041203 52.90 ENST00000652489.1
ENST00000674184.1
SAC3 domain containing 1
chr1_-_25906411 51.38 ENST00000455785.7
stathmin 1
chr18_+_21612274 50.95 ENST00000579618.1
ENST00000300413.10
ENST00000582475.1
small nuclear ribonucleoprotein D1 polypeptide
chr14_-_49688201 50.32 ENST00000553805.2
ENST00000554396.5
ENST00000216367.10
DNA polymerase epsilon 2, accessory subunit
chr15_-_66356672 50.22 ENST00000261881.9
TIMELESS interacting protein
chr11_+_65040895 49.17 ENST00000531072.1
ENST00000398846.6
SAC3 domain containing 1
chr1_+_212035717 48.72 ENST00000366991.5
denticleless E3 ubiquitin protein ligase homolog
chr2_-_46941710 46.42 ENST00000409207.5
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr22_+_35400115 45.90 ENST00000382011.9
ENST00000216122.9
ENST00000416905.1
minichromosome maintenance complex component 5
chr7_-_158704740 45.51 ENST00000409339.3
ENST00000356309.8
ENST00000409423.5
non-SMC condensin II complex subunit G2
chr7_-_26201301 42.72 ENST00000608362.2
ENST00000676749.1
ENST00000677839.1
heterogeneous nuclear ribonucleoprotein A2/B1
chr5_+_36151989 42.59 ENST00000274254.9
S-phase kinase associated protein 2
chr10_+_110567666 42.44 ENST00000361804.5
structural maintenance of chromosomes 3
chrX_+_123961696 41.80 ENST00000371145.8
ENST00000371157.7
ENST00000371144.7
stromal antigen 2
chr1_-_25905989 41.30 ENST00000399728.5
stathmin 1
chr7_-_148884266 39.96 ENST00000483967.5
ENST00000320356.7
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr3_+_44761765 39.56 ENST00000326047.9
kinesin family member 15
chr13_+_113584683 39.46 ENST00000375370.10
transcription factor Dp-1
chr1_-_25906931 39.46 ENST00000357865.6
stathmin 1
chr10_-_56361235 38.68 ENST00000373944.8
ENST00000361148.6
ENST00000395405.5
ZW10 interacting kinetochore protein
chr14_+_51240205 38.37 ENST00000457354.7
thioredoxin related transmembrane protein 1
chr20_-_33686371 36.54 ENST00000343380.6
E2F transcription factor 1
chr7_-_148884159 36.02 ENST00000478654.5
ENST00000460911.5
ENST00000350995.6
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr9_-_35079923 33.24 ENST00000378643.8
ENST00000448890.1
FA complementation group G
chr19_+_36214602 33.23 ENST00000456324.5
zinc finger protein 146
chr9_+_97983332 33.15 ENST00000339399.5
acidic nuclear phosphoprotein 32 family member B
chr10_+_13161543 33.13 ENST00000378714.8
ENST00000479669.5
ENST00000484800.6
minichromosome maintenance 10 replication initiation factor
chr2_+_47783172 32.87 ENST00000540021.6
mutS homolog 6
chr16_+_88803776 32.75 ENST00000301019.9
chromatin licensing and DNA replication factor 1
chrX_-_53422170 30.93 ENST00000675504.1
structural maintenance of chromosomes 1A
chr3_-_133661896 30.34 ENST00000260810.10
DNA topoisomerase II binding protein 1
chr6_+_135181268 28.35 ENST00000341911.10
ENST00000442647.7
ENST00000618728.4
ENST00000316528.12
ENST00000616088.4
MYB proto-oncogene, transcription factor
chr2_+_231708511 27.97 ENST00000341369.11
ENST00000409115.8
ENST00000409683.5
prothymosin alpha
chr16_-_85688912 27.79 ENST00000253462.8
GINS complex subunit 2
chr22_+_20117734 27.40 ENST00000416427.5
ENST00000421656.5
ENST00000423859.5
ENST00000418705.2
RAN binding protein 1
chr19_+_36215096 27.30 ENST00000443387.3
zinc finger protein 146
chr6_-_18264175 26.97 ENST00000651992.1
ENST00000652576.1
DEK proto-oncogene
chr6_+_135181323 26.84 ENST00000367814.8
MYB proto-oncogene, transcription factor
chr12_-_31326111 26.61 ENST00000539409.5
SIN3-HDAC complex associated factor
chr12_-_31326142 26.31 ENST00000337682.9
SIN3-HDAC complex associated factor
chrX_+_21940693 26.04 ENST00000404933.7
ENST00000379404.5
spermine synthase
chr2_-_46941760 25.92 ENST00000444761.6
ENST00000409147.1
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr6_-_27146841 25.57 ENST00000356950.2
H2B clustered histone 12
chr7_-_94656197 25.47 ENST00000643903.1
ENST00000644122.1
ENST00000447873.6
ENST00000644816.1
ENST00000644375.1
sarcoglycan epsilon
chr15_+_52019206 25.46 ENST00000681888.1
ENST00000261845.7
ENST00000680066.1
ENST00000680777.1
ENST00000680652.1
mitogen-activated protein kinase 6
chr2_-_17753792 25.41 ENST00000448223.7
ENST00000621152.4
ENST00000351948.8
structural maintenance of chromosomes 6
chr5_+_36152077 25.02 ENST00000546211.6
ENST00000620197.5
ENST00000678270.1
ENST00000679015.1
ENST00000678580.1
ENST00000274255.11
ENST00000508514.5
S-phase kinase associated protein 2
chr16_-_2980282 24.38 ENST00000572619.1
ENST00000574415.5
ENST00000440027.6
ENST00000572059.1
protein kinase, membrane associated tyrosine/threonine 1
chr2_+_47403116 23.96 ENST00000645506.1
ENST00000406134.5
ENST00000233146.7
mutS homolog 2
chr17_+_31937033 23.94 ENST00000580398.1
SUZ12 polycomb repressive complex 2 subunit
chr16_-_2980406 23.80 ENST00000431515.6
ENST00000574385.5
ENST00000576268.1
ENST00000574730.5
ENST00000262300.13
ENST00000575632.5
ENST00000573944.5
protein kinase, membrane associated tyrosine/threonine 1
chrX_+_119574748 23.69 ENST00000628549.1
ubiquitin conjugating enzyme E2 A
chr7_-_94655993 23.65 ENST00000647110.1
ENST00000647048.1
ENST00000643020.1
ENST00000644682.1
ENST00000646119.1
ENST00000646265.1
ENST00000645445.1
ENST00000647334.1
ENST00000645262.1
ENST00000428696.7
ENST00000647096.1
ENST00000642394.1
ENST00000645725.1
ENST00000647351.1
ENST00000646943.1
ENST00000648936.2
ENST00000642707.1
ENST00000645109.1
ENST00000646489.1
ENST00000642933.1
ENST00000643128.1
ENST00000445866.7
ENST00000645101.1
ENST00000644116.1
ENST00000642441.1
ENST00000646879.1
ENST00000647018.1
sarcoglycan epsilon
chrX_+_107628428 23.42 ENST00000643795.2
ENST00000372418.4
ENST00000646815.1
ENST00000372435.10
ENST00000372419.3
ENST00000676092.1
phosphoribosyl pyrophosphate synthetase 1
chr7_+_94656325 23.13 ENST00000482108.1
ENST00000488574.5
ENST00000612748.1
ENST00000613043.1
paternally expressed 10
chr1_-_222712428 23.02 ENST00000355727.3
ENST00000340020.11
axin interactor, dorsalization associated
chr2_+_47403061 22.76 ENST00000543555.6
mutS homolog 2
chr17_-_17281232 22.63 ENST00000417352.5
ENST00000268717.10
COP9 signalosome subunit 3
chr8_+_127736046 22.44 ENST00000641036.1
ENST00000377970.6
MYC proto-oncogene, bHLH transcription factor
chr17_+_31936993 22.04 ENST00000322652.10
SUZ12 polycomb repressive complex 2 subunit
chr15_+_40695423 21.90 ENST00000526763.6
ENST00000532743.6
RAD51 recombinase
chr7_-_94656160 21.77 ENST00000644609.1
ENST00000643272.1
ENST00000646137.1
ENST00000646098.1
ENST00000643193.1
ENST00000437425.7
ENST00000644551.1
ENST00000415788.3
sarcoglycan epsilon
chr14_+_93207229 21.56 ENST00000554232.5
ENST00000556871.5
ENST00000013070.11
ENST00000555113.5
ubiquitin protein ligase E3 component n-recognin 7
chr8_+_127736220 21.47 ENST00000524013.2
ENST00000621592.8
MYC proto-oncogene, bHLH transcription factor
chr20_-_5119945 21.46 ENST00000379143.10
proliferating cell nuclear antigen
chr7_+_139359846 21.27 ENST00000619796.4
ENST00000354926.9
LUC7 like 2, pre-mRNA splicing factor
chr14_+_34982963 21.07 ENST00000678627.1
ENST00000216774.11
ENST00000555557.5
signal recognition particle 54
chr4_-_169757873 20.82 ENST00000393381.3
histone PARylation factor 1
chr11_+_47215032 20.78 ENST00000622090.4
ENST00000378600.7
ENST00000378603.7
damage specific DNA binding protein 2
chr9_+_104094557 20.52 ENST00000374787.7
structural maintenance of chromosomes 2
chr7_+_120951116 20.38 ENST00000431467.1
inhibitor of growth family member 3
chr1_+_149390612 20.28 ENST00000650865.1
ENST00000652191.1
ENST00000621744.4
notch 2 N-terminal like C
novel protein, identical to neuroblastoma breakpoint family, member 19 NBPF19
chr4_+_128809684 20.09 ENST00000226319.11
ENST00000511647.5
jade family PHD finger 1
chr11_+_9384621 19.98 ENST00000379719.8
ENST00000527431.1
ENST00000630083.1
importin 7
chr22_+_20117497 19.91 ENST00000331821.7
ENST00000411892.5
RAN binding protein 1
chr11_+_47214937 19.78 ENST00000256996.9
damage specific DNA binding protein 2
chr1_-_205750167 19.22 ENST00000367142.5
nuclear casein kinase and cyclin dependent kinase substrate 1
chr3_+_52685995 19.05 ENST00000394799.6
ENST00000418458.6
G protein nucleolar 3
chr14_+_74881887 18.85 ENST00000334220.9
ENST00000626051.1
ENST00000554806.5
dihydrolipoamide S-succinyltransferase
chr11_-_119095456 18.82 ENST00000530167.1
H2A.X variant histone
chr12_+_132687570 18.63 ENST00000317479.8
ENST00000543589.5
peroxisomal membrane protein 2
chr4_+_70993542 18.61 ENST00000504730.5
ENST00000504952.1
ENST00000286648.10
deoxycytidine kinase
chr12_+_109098118 18.34 ENST00000336865.6
uracil DNA glycosylase
chrX_+_24693879 18.32 ENST00000379068.8
ENST00000677890.1
ENST00000379059.7
DNA polymerase alpha 1, catalytic subunit
chrX_+_119574530 17.71 ENST00000346330.6
ENST00000625938.2
ubiquitin conjugating enzyme E2 A
chr16_-_23596277 17.65 ENST00000562133.5
ENST00000570319.5
ENST00000007516.8
NADH:ubiquinone oxidoreductase subunit AB1
chr3_-_119677346 17.29 ENST00000484810.5
ENST00000497116.1
ENST00000261070.7
cytochrome c oxidase copper chaperone COX17
chrX_+_119574554 17.14 ENST00000371558.7
ENST00000630695.2
ENST00000631185.2
ubiquitin conjugating enzyme E2 A
chr7_-_44848021 17.06 ENST00000349299.7
ENST00000521529.5
ENST00000350771.7
ENST00000222690.10
ENST00000381124.9
ENST00000437072.5
ENST00000446531.1
ENST00000308153.9
H2A.Z variant histone 2
chr4_+_128809791 16.76 ENST00000452328.6
ENST00000504089.5
jade family PHD finger 1
chrX_-_53422644 16.67 ENST00000322213.9
ENST00000375340.10
ENST00000674590.1
structural maintenance of chromosomes 1A
chr8_+_47960883 16.48 ENST00000648407.1
ENST00000649838.1
ENST00000649919.1
ENST00000262105.6
ENST00000649973.1
minichromosome maintenance complex component 4
chrX_+_132023294 16.44 ENST00000481105.5
ENST00000354719.10
ENST00000394334.7
ENST00000394335.6
serine/threonine kinase 26
chr1_+_32651142 16.11 ENST00000414241.7
RB binding protein 4, chromatin remodeling factor
chr8_-_119855838 16.00 ENST00000313655.5
DNA replication and sister chromatid cohesion 1
chr3_+_14178808 15.97 ENST00000306024.4
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
chr7_+_120950763 15.66 ENST00000339121.9
ENST00000315870.10
ENST00000445699.5
inhibitor of growth family member 3
chr5_+_43121596 15.38 ENST00000505606.6
ENST00000509634.5
ENST00000509341.5
zinc finger protein 131
chr16_-_11915991 15.31 ENST00000420576.6
G1 to S phase transition 1
chr19_+_10655023 15.11 ENST00000590009.5
interleukin enhancer binding factor 3
chr12_+_109097568 14.86 ENST00000242576.7
uracil DNA glycosylase
chr1_-_23980345 14.82 ENST00000484146.6
serine and arginine rich splicing factor 10
chr16_-_50368920 14.74 ENST00000394688.8
bromodomain containing 7
chr11_+_63974578 14.57 ENST00000314133.4
ENST00000535431.1
cytochrome c oxidase subunit 8A
novel transcript
chr12_+_57230086 14.31 ENST00000414700.7
ENST00000557703.5
serine hydroxymethyltransferase 2
chr5_+_43120883 14.30 ENST00000515326.5
ENST00000682664.1
zinc finger protein 131
chr9_+_83980757 14.25 ENST00000325875.7
ENST00000445877.6
RecQ mediated genome instability 1
chr6_-_159789660 14.06 ENST00000538128.5
ENST00000537390.5
ENST00000392168.6
t-complex 1
chr8_+_47961028 13.42 ENST00000650216.1
minichromosome maintenance complex component 4
chr10_-_121975168 13.24 ENST00000369017.5
ENST00000369023.8
NSE4 homolog A, SMC5-SMC6 complex component
chr1_+_32651164 13.19 ENST00000373493.10
ENST00000373485.5
ENST00000458695.6
RB binding protein 4, chromatin remodeling factor
chr5_+_139293700 13.09 ENST00000504045.5
ENST00000504311.5
ENST00000502499.5
matrin 3
chr16_+_67562453 13.06 ENST00000646076.1
CCCTC-binding factor
chr11_-_19241598 12.86 ENST00000532666.1
ENST00000527884.5
ENST00000620009.4
E2F transcription factor 8
chr14_+_60249191 12.84 ENST00000395076.9
protein phosphatase, Mg2+/Mn2+ dependent 1A
chrX_-_153470555 12.69 ENST00000370211.10
ENST00000330912.7
ENST00000334497.7
ENST00000338525.7
ENST00000370232.4
HAUS augmin like complex subunit 7
three prime repair exonuclease 2
chr11_+_74592567 12.55 ENST00000263681.7
ENST00000527458.5
ENST00000532497.5
ENST00000530511.5
DNA polymerase delta 3, accessory subunit
chr17_-_58007217 12.53 ENST00000258962.5
ENST00000582730.6
ENST00000584773.5
ENST00000585096.1
serine and arginine rich splicing factor 1
chr5_+_140639494 12.29 ENST00000252100.6
transmembrane and coiled-coil domains 6
chr9_+_104094260 12.23 ENST00000286398.11
ENST00000440179.5
ENST00000374793.8
structural maintenance of chromosomes 2
chr16_+_67562514 11.97 ENST00000264010.10
ENST00000401394.6
ENST00000646771.1
CCCTC-binding factor
chr14_-_69398276 11.87 ENST00000557016.6
ENST00000555373.1
ERH mRNA splicing and mitosis factor
chr5_+_43121504 11.86 ENST00000509156.5
ENST00000508259.5
ENST00000306938.8
zinc finger protein 131
chr6_+_20401864 11.77 ENST00000346618.8
ENST00000613242.4
E2F transcription factor 3
chr14_-_67674583 11.50 ENST00000554659.6
vesicle transport through interaction with t-SNAREs 1B
chr10_-_13348270 11.20 ENST00000378614.8
ENST00000327347.10
ENST00000545675.5
selenophosphate synthetase 1
chr19_+_49085433 11.03 ENST00000221448.9
ENST00000598441.6
small nuclear ribonucleoprotein U1 subunit 70
chr3_-_185938006 10.86 ENST00000342294.4
ENST00000453386.7
ENST00000382191.4
transformer 2 beta homolog
chr1_+_120723939 10.84 ENST00000624419.2
ENST00000652763.1
ENST00000620612.5
notch 2 N-terminal like R (pseudogene)
NBPF member 26
chr5_+_74767234 10.79 ENST00000610426.5
NSA2 ribosome biogenesis factor
chr22_+_35257452 10.77 ENST00000420166.5
ENST00000216106.6
ENST00000455359.5
HMG-box containing 4
chr17_+_3668803 10.63 ENST00000248378.6
ENST00000397133.2
ER membrane protein complex subunit 6
chr6_+_31665234 10.58 ENST00000677536.1
ENST00000375885.8
casein kinase 2 beta
chr5_+_139293728 10.51 ENST00000510056.5
ENST00000511249.5
ENST00000394805.8
ENST00000503811.5
ENST00000618441.5
matrin 3
chr17_+_40287861 10.37 ENST00000209728.9
ENST00000580824.5
ENST00000577249.1
ENST00000649662.1
cell division cycle 6
chr2_-_99489955 10.02 ENST00000393445.7
ENST00000258428.8
REV1 DNA directed polymerase
chr16_+_28950807 9.81 ENST00000564978.5
ENST00000320805.8
nuclear factor of activated T cells 2 interacting protein
chr2_-_173965356 9.81 ENST00000310015.12
Sp3 transcription factor
chr17_+_50719565 9.79 ENST00000625349.2
ENST00000393227.6
ENST00000240304.5
ENST00000505658.6
ENST00000505619.5
ENST00000510984.5
LUC7 like 3 pre-mRNA splicing factor
chr2_-_27409523 9.77 ENST00000344034.5
protein phosphatase, Mg2+/Mn2+ dependent 1G
chr7_+_6009222 9.36 ENST00000400479.6
ENST00000223029.8
ENST00000395236.2
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
chr5_+_140639419 9.32 ENST00000513002.5
ENST00000394671.8
transmembrane and coiled-coil domains 6
chr20_-_63216102 9.20 ENST00000370339.8
ENST00000370334.4
YTH N6-methyladenosine RNA binding protein 1
chrX_+_71533095 9.17 ENST00000373719.8
ENST00000373701.7
O-linked N-acetylglucosamine (GlcNAc) transferase
chr6_+_87590067 9.09 ENST00000546266.5
ENST00000257789.4
ENST00000392844.8
origin recognition complex subunit 3
chr6_+_30345131 9.06 ENST00000433076.6
ENST00000442966.7
ENST00000428040.6
ENST00000436442.2
ribonuclease P/MRP subunit p21
chr3_-_142149515 8.95 ENST00000475734.5
ENST00000467072.5
ENST00000489671.6
transcription factor Dp-2
chr12_+_121888751 8.90 ENST00000261817.6
ENST00000538613.5
ENST00000542602.1
ENST00000541212.6
proteasome 26S subunit, non-ATPase 9
chr1_-_23344314 8.78 ENST00000374612.5
ENST00000675048.1
ENST00000478691.5
heterogeneous nuclear ribonucleoprotein R
chr18_-_56651122 8.74 ENST00000590954.5
thioredoxin like 1
chr13_+_97976632 8.62 ENST00000490680.5
ENST00000403772.8
importin 5
chr19_-_49929454 8.12 ENST00000597723.5
ENST00000599788.1
ENST00000352066.8
ENST00000596217.1
ENST00000593652.5
ENST00000599567.5
ENST00000600935.1
ENST00000596011.1
ENST00000596022.5
ENST00000597295.5
nucleoporin 62
interleukin 4 induced 1
chr1_-_23344259 8.07 ENST00000476451.2
ENST00000302271.11
ENST00000606561.5
ENST00000374616.7
heterogeneous nuclear ribonucleoprotein R
chr22_-_28741783 8.03 ENST00000439200.5
ENST00000405598.5
ENST00000398017.3
ENST00000649563.1
ENST00000650281.1
ENST00000425190.7
ENST00000404276.6
ENST00000650233.1
ENST00000348295.7
ENST00000382580.6
checkpoint kinase 2
chr12_+_57229694 7.98 ENST00000557487.5
ENST00000328923.8
ENST00000555634.5
ENST00000556689.5
serine hydroxymethyltransferase 2
chr1_+_226063466 7.91 ENST00000666609.1
ENST00000661429.1
H3.3 histone A
chr19_+_2236816 7.86 ENST00000221494.10
splicing factor 3a subunit 2
chr16_-_47461039 7.71 ENST00000320640.11
integrin alpha FG-GAP repeat containing 1
chr3_-_48188356 7.70 ENST00000351231.7
ENST00000437972.1
ENST00000302506.8
cell division cycle 25A
chr3_+_41199389 7.40 ENST00000396185.8
ENST00000642986.1
ENST00000644678.1
ENST00000396183.7
ENST00000643031.1
ENST00000645982.1
ENST00000453024.6
catenin beta 1
chr5_+_74766981 7.39 ENST00000296802.9
NSA2 ribosome biogenesis factor
chr13_+_45120493 7.27 ENST00000340473.8
general transcription factor IIF subunit 2
chr11_-_64778469 7.24 ENST00000377387.5
splicing factor 1
chr11_+_66616606 7.22 ENST00000393979.3
ENST00000409372.1
ENST00000310137.5
ENST00000443702.1
ENST00000409738.4
ENST00000412278.2
ENST00000500635.2
RNA binding motif protein 14
RBM14-RBM4 readthrough
chr11_-_64778747 7.14 ENST00000227503.13
ENST00000377394.7
ENST00000334944.9
splicing factor 1
chr6_+_36027796 7.08 ENST00000229794.9
mitogen-activated protein kinase 14
chr11_+_9573633 7.05 ENST00000450114.7
WEE1 G2 checkpoint kinase
chr12_+_53454718 7.00 ENST00000552819.5
ENST00000455667.7
poly(rC) binding protein 2
chrX_-_107000185 6.89 ENST00000355610.9
MORC family CW-type zinc finger 4
chr15_+_32615501 6.85 ENST00000361627.8
ENST00000567348.5
ENST00000563864.5
ENST00000543522.5
Rho GTPase activating protein 11A
chr16_+_47461290 6.77 ENST00000566044.5
phosphorylase kinase regulatory subunit beta
chr9_-_128128102 6.76 ENST00000617202.4
prostaglandin E synthase 2
chr17_-_59106801 6.66 ENST00000393065.6
ENST00000262294.12
ENST00000393066.7
tripartite motif containing 37
chr12_+_93572664 6.62 ENST00000551556.2
suppressor of cytokine signaling 2
chr21_-_28992815 6.46 ENST00000361371.10
listerin E3 ubiquitin protein ligase 1
chr19_+_50384323 6.35 ENST00000599857.7
ENST00000613923.6
ENST00000601098.6
ENST00000440232.7
ENST00000595904.6
ENST00000593887.1
DNA polymerase delta 1, catalytic subunit
chr3_-_9986682 6.30 ENST00000429759.5
ER membrane protein complex subunit 3
chr6_+_135181361 6.25 ENST00000527615.5
ENST00000420123.6
ENST00000525369.5
ENST00000528774.5
ENST00000533624.5
ENST00000534044.5
ENST00000534121.5
MYB proto-oncogene, transcription factor
chr16_-_11915878 6.19 ENST00000439887.6
ENST00000434724.7
G1 to S phase transition 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
45.3 226.6 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
37.1 111.3 GO:0046452 dihydrofolate metabolic process(GO:0046452)
35.2 457.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
30.0 239.7 GO:0090166 regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166)
25.3 76.0 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
20.5 61.4 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
18.1 217.6 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
17.0 84.8 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
16.5 65.9 GO:0035822 gene conversion(GO:0035822)
16.0 16.0 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
11.9 143.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
11.3 67.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
11.1 277.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
11.0 131.8 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
11.0 43.9 GO:0090096 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
11.0 87.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
10.7 21.5 GO:0006272 leading strand elongation(GO:0006272)
10.0 50.2 GO:0048478 replication fork protection(GO:0048478)
9.1 9.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
8.4 303.1 GO:0006270 DNA replication initiation(GO:0006270)
8.2 81.9 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
7.6 98.7 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
7.2 21.5 GO:0002184 cytoplasmic translational termination(GO:0002184)
7.1 42.7 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
6.9 20.8 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
6.3 18.8 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
5.8 17.3 GO:1904732 regulation of electron carrier activity(GO:1904732)
5.6 22.3 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
5.5 32.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
5.3 21.1 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
5.0 25.0 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
4.7 23.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) AMP biosynthetic process(GO:0006167) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
4.1 40.6 GO:0006290 pyrimidine dimer repair(GO:0006290)
4.0 27.8 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
4.0 31.8 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
3.9 35.3 GO:0000710 meiotic mismatch repair(GO:0000710)
3.8 250.6 GO:0006301 postreplication repair(GO:0006301)
3.7 26.0 GO:0008215 spermine metabolic process(GO:0008215)
3.7 29.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
3.3 9.8 GO:0042023 regulation of DNA endoreduplication(GO:0032875) DNA endoreduplication(GO:0042023)
3.2 25.4 GO:0000722 telomere maintenance via recombination(GO:0000722)
3.1 9.2 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
3.0 8.9 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
2.8 36.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
2.8 11.0 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
2.7 8.0 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
2.6 31.0 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
2.3 14.0 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
2.2 15.6 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
2.2 6.5 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
2.2 25.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
2.1 18.6 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157)
2.0 40.1 GO:0070734 histone H3-K27 methylation(GO:0070734)
2.0 14.0 GO:0006499 N-terminal protein myristoylation(GO:0006499)
2.0 17.6 GO:0009249 protein lipoylation(GO:0009249)
1.9 9.4 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
1.8 12.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
1.8 50.9 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
1.5 13.9 GO:0046600 negative regulation of centriole replication(GO:0046600)
1.5 22.6 GO:0000338 protein deneddylation(GO:0000338)
1.5 19.1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
1.4 11.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
1.4 11.2 GO:0001887 selenium compound metabolic process(GO:0001887)
1.4 36.0 GO:0043968 histone H2A acetylation(GO:0043968)
1.3 13.5 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
1.3 10.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
1.3 7.9 GO:0060356 leucine import(GO:0060356)
1.2 31.1 GO:0006376 mRNA splice site selection(GO:0006376)
1.1 33.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.9 54.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.9 16.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.9 2.6 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.8 10.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.8 2.4 GO:0003420 regulation of growth plate cartilage chondrocyte proliferation(GO:0003420)
0.8 64.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.8 14.2 GO:0000732 strand displacement(GO:0000732)
0.8 10.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.7 3.0 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.7 14.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.7 1.4 GO:0031393 negative regulation of prostaglandin biosynthetic process(GO:0031393)
0.7 9.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.6 16.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.6 16.9 GO:0061157 mRNA destabilization(GO:0061157)
0.6 53.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.6 18.2 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.6 5.9 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.5 23.0 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.5 1.9 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.4 7.0 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.4 14.7 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.4 2.6 GO:0033504 floor plate development(GO:0033504)
0.4 39.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 5.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.4 16.0 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.4 9.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.4 4.3 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.4 7.3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.4 6.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.4 11.9 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.3 27.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 4.3 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.3 9.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.3 5.9 GO:0033197 response to vitamin E(GO:0033197)
0.3 0.3 GO:0072387 flavin adenine dinucleotide metabolic process(GO:0072387)
0.3 7.7 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 20.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.2 37.7 GO:0006338 chromatin remodeling(GO:0006338)
0.2 4.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 3.1 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.2 11.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 15.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 5.9 GO:0015695 organic cation transport(GO:0015695)
0.2 11.8 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)
0.1 9.4 GO:0001541 ovarian follicle development(GO:0001541)
0.1 12.7 GO:0051225 spindle assembly(GO:0051225)
0.1 0.5 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 1.6 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 3.9 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 9.8 GO:0016925 protein sumoylation(GO:0016925)
0.1 9.8 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 3.9 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.1 28.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 0.8 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 2.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 5.8 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 2.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 2.8 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 1.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.4 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 4.1 GO:0008584 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 6.1 GO:0006364 rRNA processing(GO:0006364)
0.0 0.6 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
69.4 277.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
59.9 239.7 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
44.4 577.6 GO:0042555 MCM complex(GO:0042555)
30.2 120.9 GO:0000811 GINS complex(GO:0000811)
16.4 82.0 GO:0032301 MutSalpha complex(GO:0032301)
14.1 42.4 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
13.9 83.3 GO:0031298 replication fork protection complex(GO:0031298)
13.4 40.2 GO:0035189 Rb-E2F complex(GO:0035189)
11.9 47.6 GO:0030893 meiotic cohesin complex(GO:0030893)
11.7 58.5 GO:0033503 HULC complex(GO:0033503)
9.9 39.6 GO:0005873 plus-end kinesin complex(GO:0005873)
9.8 78.3 GO:0000796 condensin complex(GO:0000796)
9.7 38.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
9.1 9.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
9.0 36.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
8.9 70.9 GO:0016012 sarcoglycan complex(GO:0016012)
8.1 89.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
8.1 40.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
7.7 62.0 GO:0000243 commitment complex(GO:0000243)
7.6 159.8 GO:0005721 pericentric heterochromatin(GO:0005721)
7.3 29.3 GO:0033186 CAF-1 complex(GO:0033186)
7.2 21.5 GO:0018444 translation release factor complex(GO:0018444)
6.6 46.0 GO:0001739 sex chromatin(GO:0001739)
5.9 23.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
5.4 76.0 GO:0045120 pronucleus(GO:0045120)
4.3 21.5 GO:0070557 PCNA-p21 complex(GO:0070557)
3.8 18.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
3.7 18.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
3.5 10.6 GO:1903349 omegasome membrane(GO:1903349)
2.9 5.9 GO:0035061 interchromatin granule(GO:0035061)
2.7 18.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
2.7 16.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
2.7 16.0 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
2.4 7.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
2.3 21.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
2.3 30.3 GO:0001673 male germ cell nucleus(GO:0001673)
2.3 9.2 GO:0031510 SUMO activating enzyme complex(GO:0031510)
2.3 38.9 GO:0071004 U2-type prespliceosome(GO:0071004)
2.2 29.1 GO:0000800 lateral element(GO:0000800)
2.2 22.3 GO:0070552 BRISC complex(GO:0070552)
2.2 10.8 GO:0016589 NURF complex(GO:0016589)
1.6 9.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.5 10.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
1.4 12.7 GO:0070652 HAUS complex(GO:0070652)
1.3 67.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
1.2 15.6 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.1 14.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.1 11.9 GO:0034709 methylosome(GO:0034709)
1.1 83.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
1.0 10.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.9 9.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.9 6.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.8 131.1 GO:0016363 nuclear matrix(GO:0016363)
0.8 6.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.7 71.4 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.7 18.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.6 3.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.6 8.9 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.6 18.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.5 6.5 GO:0090543 Flemming body(GO:0090543)
0.5 22.6 GO:0008180 COP9 signalosome(GO:0008180)
0.5 86.8 GO:0005819 spindle(GO:0005819)
0.4 42.3 GO:0000775 chromosome, centromeric region(GO:0000775)
0.4 12.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.4 7.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.4 5.2 GO:0043601 nuclear replisome(GO:0043601)
0.4 37.2 GO:0036064 ciliary basal body(GO:0036064)
0.3 14.7 GO:0090544 BAF-type complex(GO:0090544)
0.3 152.7 GO:0005874 microtubule(GO:0005874)
0.3 28.6 GO:0005643 nuclear pore(GO:0005643)
0.3 20.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 5.8 GO:0044232 organelle membrane contact site(GO:0044232)
0.3 51.9 GO:0005681 spliceosomal complex(GO:0005681)
0.3 1.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 41.5 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.2 4.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 77.1 GO:0043292 contractile fiber(GO:0043292)
0.2 1.9 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.2 17.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 16.4 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.2 7.2 GO:0016592 mediator complex(GO:0016592)
0.2 6.7 GO:0016235 aggresome(GO:0016235)
0.1 8.7 GO:0000502 proteasome complex(GO:0000502)
0.1 93.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 19.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.8 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 6.4 GO:0016605 PML body(GO:0016605)
0.1 32.2 GO:0005635 nuclear envelope(GO:0005635)
0.1 1.4 GO:0034451 centriolar satellite(GO:0034451)
0.1 70.1 GO:0005730 nucleolus(GO:0005730)
0.1 7.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.4 GO:0000445 transcription export complex(GO:0000346) THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 41.1 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
69.4 277.5 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
27.8 111.3 GO:0004146 dihydrofolate reductase activity(GO:0004146)
16.4 82.0 GO:0032143 single thymine insertion binding(GO:0032143)
14.8 88.9 GO:0036033 mediator complex binding(GO:0036033)
14.1 84.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
10.9 239.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
10.4 177.6 GO:0003688 DNA replication origin binding(GO:0003688)
10.3 62.0 GO:1990446 U1 snRNP binding(GO:1990446)
10.1 120.9 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
8.7 122.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
8.6 343.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
8.3 25.0 GO:0043035 chromatin insulator sequence binding(GO:0043035)
8.3 75.0 GO:1990226 histone methyltransferase binding(GO:1990226)
7.2 21.5 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
6.7 20.0 GO:0045131 pre-mRNA branch point binding(GO:0045131)
5.9 17.6 GO:0000035 acyl binding(GO:0000035)
4.8 38.3 GO:0050733 RS domain binding(GO:0050733)
4.3 51.9 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
4.0 40.4 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
3.9 23.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
3.7 22.3 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
3.5 21.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
3.3 33.2 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
3.1 18.8 GO:0016748 succinyltransferase activity(GO:0016748)
3.1 21.5 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
3.1 9.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
2.8 80.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
2.7 18.6 GO:0004137 deoxycytidine kinase activity(GO:0004137)
2.6 28.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
2.2 17.3 GO:0016531 copper chaperone activity(GO:0016531)
2.1 12.7 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
1.8 198.8 GO:0070491 repressing transcription factor binding(GO:0070491)
1.7 8.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.6 377.5 GO:0042393 histone binding(GO:0042393)
1.6 38.4 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
1.6 14.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
1.4 14.0 GO:0051525 NFAT protein binding(GO:0051525)
1.4 19.0 GO:0031386 protein tag(GO:0031386)
1.4 6.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
1.3 58.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.3 15.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.2 31.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.0 10.2 GO:0004689 phosphorylase kinase activity(GO:0004689)
1.0 25.5 GO:0004707 MAP kinase activity(GO:0004707)
1.0 107.4 GO:0004386 helicase activity(GO:0004386)
0.9 1.9 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.9 3.7 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.9 7.0 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.8 6.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.8 16.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.8 9.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.7 37.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.7 6.0 GO:0034511 U3 snoRNA binding(GO:0034511)
0.7 4.6 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.7 6.5 GO:0051425 PTB domain binding(GO:0051425)
0.6 7.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.5 14.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 39.6 GO:0003777 microtubule motor activity(GO:0003777)
0.5 1.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.5 15.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.5 2.3 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.5 5.0 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.4 66.9 GO:0031072 heat shock protein binding(GO:0031072)
0.4 154.9 GO:0015631 tubulin binding(GO:0015631)
0.4 16.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 5.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.4 151.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 8.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.3 60.5 GO:0008201 heparin binding(GO:0008201)
0.3 26.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.3 15.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.3 34.6 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 2.8 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 3.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.3 51.8 GO:0001047 core promoter binding(GO:0001047)
0.2 7.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.2 8.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 15.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 5.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 16.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 18.3 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.8 GO:0005047 signal recognition particle binding(GO:0005047)
0.1 8.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 2.9 GO:0048038 quinone binding(GO:0048038)
0.1 28.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 10.3 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 7.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 14.1 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 23.0 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 3.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 14.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 5.9 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 23.6 GO:0005198 structural molecule activity(GO:0005198)
0.0 23.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 1.6 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
18.2 254.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
10.9 217.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
5.4 326.8 PID ATR PATHWAY ATR signaling pathway
5.1 616.7 PID E2F PATHWAY E2F transcription factor network
3.4 98.1 PID ATM PATHWAY ATM pathway
1.9 67.6 PID MYC PATHWAY C-MYC pathway
1.3 14.2 PID FANCONI PATHWAY Fanconi anemia pathway
1.1 61.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
1.1 100.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.7 41.8 PID PLK1 PATHWAY PLK1 signaling events
0.6 109.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.5 6.8 PID IFNG PATHWAY IFN-gamma pathway
0.5 9.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.4 16.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 10.6 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.3 6.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.3 24.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 7.4 PID AURORA B PATHWAY Aurora B signaling
0.1 9.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 5.6 PID LKB1 PATHWAY LKB1 signaling events
0.1 2.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.8 PID CMYB PATHWAY C-MYB transcription factor network
0.1 4.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 3.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
46.5 697.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
26.5 795.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
13.4 200.7 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
4.4 78.6 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
2.4 55.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
2.4 18.9 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
2.1 107.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
1.9 75.0 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
1.7 29.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
1.7 77.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
1.6 29.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
1.4 124.1 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
1.4 39.6 REACTOME KINESINS Genes involved in Kinesins
1.3 8.0 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
1.3 72.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
1.3 26.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.1 25.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.1 8.6 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
1.0 9.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.9 16.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.8 89.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.8 18.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.7 18.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.7 14.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.6 14.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.5 2.0 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.5 66.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.5 15.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4 38.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 35.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.4 9.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.4 10.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 28.1 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.3 62.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 7.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 10.6 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 3.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 21.1 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 2.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 5.9 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 0.9 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling