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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for E2F3
Z-value: 2.88
Motif logo
Transcription factors associated with E2F3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
E2F3
|
ENSG00000112242.15 | E2F3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F3 | hg38_v1_chr6_+_20403679_20403735, hg38_v1_chr6_+_20401864_20401921 | 0.67 | 2.5e-29 | Click! |
Activity profile of E2F3 motif
Sorted Z-values of E2F3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.5 | 94.5 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 23.1 | 69.2 | GO:0046080 | dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081) |
| 18.2 | 54.7 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 16.9 | 101.4 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 16.1 | 48.3 | GO:1904772 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 15.9 | 47.8 | GO:0051793 | medium-chain fatty acid catabolic process(GO:0051793) |
| 15.7 | 47.0 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 15.0 | 59.8 | GO:1903755 | regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755) |
| 14.0 | 153.9 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 13.4 | 53.4 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 13.0 | 13.0 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 12.6 | 37.7 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 12.5 | 100.1 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 12.5 | 37.5 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 12.3 | 49.2 | GO:0090579 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 12.3 | 36.8 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 11.8 | 11.8 | GO:0043504 | mitochondrial DNA repair(GO:0043504) |
| 11.4 | 11.4 | GO:0033512 | L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) |
| 10.8 | 54.0 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 10.4 | 31.2 | GO:1903778 | protein localization to vacuolar membrane(GO:1903778) |
| 10.3 | 61.8 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 10.3 | 41.2 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 10.2 | 20.5 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 10.0 | 30.0 | GO:0072019 | proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 9.8 | 78.1 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 9.3 | 9.3 | GO:1903181 | regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) |
| 9.2 | 27.7 | GO:0014810 | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014810) |
| 9.2 | 27.7 | GO:1900195 | spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195) |
| 9.2 | 36.9 | GO:0044837 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 9.2 | 46.0 | GO:0044209 | AMP salvage(GO:0044209) |
| 9.1 | 27.4 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 8.7 | 43.3 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 8.4 | 25.1 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 8.4 | 25.1 | GO:0036265 | RNA (guanine-N7)-methylation(GO:0036265) rRNA (guanine-N7)-methylation(GO:0070476) |
| 8.3 | 50.0 | GO:0033490 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 8.2 | 16.4 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 7.9 | 31.8 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 7.7 | 30.9 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 7.6 | 30.5 | GO:1904924 | negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924) |
| 7.6 | 22.8 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 7.5 | 59.7 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 7.4 | 29.5 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 7.3 | 43.9 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 7.3 | 36.3 | GO:0009136 | purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188) |
| 7.1 | 21.4 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 7.1 | 14.2 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 7.0 | 20.9 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 6.9 | 13.9 | GO:1903595 | positive regulation of histamine secretion by mast cell(GO:1903595) |
| 6.8 | 20.3 | GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 6.7 | 39.9 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 6.6 | 19.9 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 6.6 | 52.8 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 6.6 | 39.5 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 6.5 | 45.7 | GO:1904431 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431) |
| 6.5 | 19.6 | GO:0072334 | UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334) |
| 6.5 | 65.0 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 6.5 | 32.3 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 6.4 | 89.4 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 6.4 | 31.8 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 6.4 | 19.1 | GO:2000374 | regulation of oxygen metabolic process(GO:2000374) |
| 6.3 | 31.4 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 6.2 | 43.5 | GO:1903333 | negative regulation of protein folding(GO:1903333) |
| 6.1 | 6.1 | GO:1900110 | negative regulation of histone H3-K9 dimethylation(GO:1900110) |
| 6.0 | 18.1 | GO:1903352 | ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352) |
| 6.0 | 66.2 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 6.0 | 18.0 | GO:0000472 | endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471) |
| 5.9 | 17.8 | GO:0006864 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 5.9 | 23.7 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 5.9 | 23.5 | GO:0036114 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 5.7 | 17.2 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 5.7 | 40.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 5.6 | 425.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 5.5 | 16.4 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 5.3 | 26.7 | GO:0071033 | nuclear retention of pre-mRNA at the site of transcription(GO:0071033) |
| 5.3 | 16.0 | GO:0009085 | lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) |
| 5.3 | 26.7 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 5.3 | 26.4 | GO:0043137 | DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137) |
| 5.2 | 20.9 | GO:0033313 | meiotic cell cycle checkpoint(GO:0033313) |
| 5.2 | 5.2 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) |
| 5.2 | 31.0 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
| 5.2 | 15.5 | GO:0001189 | RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189) |
| 5.0 | 30.2 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
| 5.0 | 40.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 5.0 | 15.0 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 4.9 | 14.7 | GO:0034635 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 4.9 | 29.1 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 4.8 | 67.5 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 4.8 | 19.2 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 4.8 | 19.1 | GO:0072526 | pyridine-containing compound catabolic process(GO:0072526) |
| 4.7 | 28.3 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 4.7 | 75.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 4.7 | 23.3 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 4.6 | 37.2 | GO:0048478 | replication fork protection(GO:0048478) |
| 4.6 | 9.2 | GO:0009838 | abscission(GO:0009838) |
| 4.6 | 23.0 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 4.6 | 13.7 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 4.5 | 131.6 | GO:0006465 | signal peptide processing(GO:0006465) |
| 4.5 | 31.5 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 4.5 | 94.2 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 4.5 | 17.9 | GO:0009440 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 4.4 | 31.0 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 4.4 | 52.3 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 4.3 | 13.0 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 4.2 | 71.7 | GO:0031163 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 4.2 | 16.8 | GO:0044789 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 4.2 | 4.2 | GO:0090235 | regulation of metaphase plate congression(GO:0090235) |
| 4.1 | 49.7 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 4.1 | 16.5 | GO:0048254 | snoRNA localization(GO:0048254) |
| 4.1 | 12.3 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 4.1 | 8.2 | GO:1903978 | regulation of microglial cell activation(GO:1903978) |
| 4.1 | 32.7 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 4.1 | 52.7 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 4.0 | 12.1 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 4.0 | 27.8 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 4.0 | 27.7 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 3.9 | 74.9 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 3.9 | 27.4 | GO:0045040 | protein import into mitochondrial outer membrane(GO:0045040) |
| 3.8 | 11.5 | GO:1904732 | regulation of electron carrier activity(GO:1904732) |
| 3.8 | 15.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 3.7 | 22.5 | GO:0015853 | adenine transport(GO:0015853) |
| 3.7 | 11.1 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 3.7 | 14.8 | GO:1901873 | regulation of post-translational protein modification(GO:1901873) |
| 3.7 | 3.7 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 3.7 | 11.0 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 3.6 | 14.6 | GO:1902775 | mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 3.6 | 36.4 | GO:0060717 | chorion development(GO:0060717) |
| 3.6 | 50.7 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 3.6 | 14.4 | GO:0016333 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 3.6 | 10.7 | GO:0098507 | polynucleotide 5' dephosphorylation(GO:0098507) |
| 3.5 | 42.3 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 3.5 | 17.3 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 3.4 | 17.2 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 3.4 | 13.7 | GO:0000961 | negative regulation of mitochondrial RNA catabolic process(GO:0000961) |
| 3.4 | 23.9 | GO:0032077 | positive regulation of deoxyribonuclease activity(GO:0032077) |
| 3.4 | 23.8 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 3.3 | 13.4 | GO:0042450 | arginine biosynthetic process via ornithine(GO:0042450) |
| 3.2 | 13.0 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 3.2 | 12.9 | GO:0003290 | atrial septum secundum morphogenesis(GO:0003290) |
| 3.2 | 134.2 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 3.2 | 9.6 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 3.2 | 15.9 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 3.2 | 34.8 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 3.2 | 28.5 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 3.2 | 12.6 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 3.2 | 9.5 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 3.1 | 9.4 | GO:0043634 | exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) polyadenylation-dependent ncRNA catabolic process(GO:0043634) nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046) |
| 3.1 | 59.0 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 3.1 | 46.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 3.1 | 6.1 | GO:0035511 | oxidative DNA demethylation(GO:0035511) |
| 3.1 | 30.7 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 3.1 | 15.4 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
| 3.1 | 9.2 | GO:0043461 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
| 3.1 | 15.3 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 3.0 | 36.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 3.0 | 15.1 | GO:0050428 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 3.0 | 39.0 | GO:0045008 | depyrimidination(GO:0045008) |
| 2.9 | 11.7 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) |
| 2.9 | 23.0 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 2.9 | 8.6 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 2.9 | 2.9 | GO:0021539 | subthalamus development(GO:0021539) |
| 2.8 | 8.4 | GO:1990535 | neuron projection maintenance(GO:1990535) |
| 2.8 | 35.8 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 2.7 | 235.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 2.7 | 13.5 | GO:0003164 | His-Purkinje system development(GO:0003164) |
| 2.7 | 5.4 | GO:0031126 | snoRNA 3'-end processing(GO:0031126) |
| 2.7 | 37.4 | GO:0030497 | fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761) |
| 2.7 | 48.0 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 2.7 | 18.7 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 2.7 | 31.9 | GO:0010917 | negative regulation of mitochondrial membrane potential(GO:0010917) |
| 2.7 | 2.7 | GO:0000960 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 2.6 | 21.0 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 2.6 | 18.2 | GO:0070200 | establishment of protein localization to telomere(GO:0070200) |
| 2.6 | 33.7 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 2.6 | 18.0 | GO:0042998 | regulation of Golgi to plasma membrane protein transport(GO:0042996) positive regulation of Golgi to plasma membrane protein transport(GO:0042998) |
| 2.6 | 10.3 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 2.6 | 5.1 | GO:0048319 | axial mesoderm morphogenesis(GO:0048319) |
| 2.5 | 30.5 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 2.5 | 52.9 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
| 2.5 | 7.6 | GO:0015746 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 2.5 | 170.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 2.5 | 10.0 | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport(GO:0090481) |
| 2.5 | 7.4 | GO:0033386 | geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386) |
| 2.4 | 19.5 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 2.4 | 9.7 | GO:0030047 | actin modification(GO:0030047) |
| 2.4 | 7.2 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 2.4 | 16.9 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 2.4 | 40.9 | GO:0051231 | mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) |
| 2.4 | 114.3 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 2.4 | 11.8 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 2.4 | 9.4 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 2.3 | 25.8 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 2.3 | 23.5 | GO:0000469 | cleavage involved in rRNA processing(GO:0000469) |
| 2.3 | 16.3 | GO:0000012 | single strand break repair(GO:0000012) |
| 2.3 | 30.2 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 2.3 | 11.6 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 2.3 | 6.9 | GO:0002314 | germinal center B cell differentiation(GO:0002314) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 2.3 | 16.0 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 2.3 | 25.0 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 2.3 | 22.6 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 2.3 | 20.3 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 2.3 | 20.3 | GO:0001866 | NK T cell proliferation(GO:0001866) |
| 2.3 | 9.0 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 2.2 | 15.7 | GO:1902188 | positive regulation of viral release from host cell(GO:1902188) |
| 2.2 | 11.2 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 2.2 | 11.0 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 2.2 | 15.3 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 2.2 | 6.6 | GO:0006059 | hexitol metabolic process(GO:0006059) |
| 2.2 | 10.9 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 2.2 | 2.2 | GO:1901187 | regulation of ephrin receptor signaling pathway(GO:1901187) |
| 2.1 | 6.4 | GO:0060739 | mesenchymal-epithelial cell signaling involved in prostate gland development(GO:0060739) |
| 2.1 | 10.7 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 2.1 | 6.3 | GO:0036233 | glycine import(GO:0036233) |
| 2.1 | 23.1 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 2.1 | 6.2 | GO:0031456 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 2.1 | 14.4 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 2.1 | 4.1 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
| 2.0 | 63.2 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 2.0 | 14.1 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 2.0 | 24.0 | GO:0046149 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 2.0 | 4.0 | GO:0060003 | copper ion export(GO:0060003) |
| 2.0 | 9.9 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 2.0 | 5.9 | GO:0042727 | flavin-containing compound biosynthetic process(GO:0042727) |
| 2.0 | 3.9 | GO:1903970 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
| 2.0 | 11.8 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 1.9 | 19.1 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) |
| 1.9 | 7.6 | GO:0009256 | 10-formyltetrahydrofolate metabolic process(GO:0009256) |
| 1.9 | 9.5 | GO:0034351 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 1.9 | 15.0 | GO:0021943 | formation of radial glial scaffolds(GO:0021943) |
| 1.9 | 7.5 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 1.8 | 5.5 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 1.8 | 60.7 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 1.8 | 9.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 1.8 | 23.7 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 1.8 | 9.1 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 1.8 | 12.7 | GO:0097680 | double-strand break repair via classical nonhomologous end joining(GO:0097680) |
| 1.8 | 116.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.8 | 63.9 | GO:0034080 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 1.7 | 31.4 | GO:0031639 | plasminogen activation(GO:0031639) |
| 1.7 | 8.7 | GO:0006574 | valine catabolic process(GO:0006574) |
| 1.7 | 15.5 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 1.7 | 13.8 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 1.7 | 44.7 | GO:0097340 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 1.7 | 8.4 | GO:1901159 | glucuronate catabolic process(GO:0006064) glucuronate catabolic process to xylulose 5-phosphate(GO:0019640) xylulose 5-phosphate metabolic process(GO:0051167) xylulose 5-phosphate biosynthetic process(GO:1901159) |
| 1.7 | 5.0 | GO:1902905 | positive regulation of fibril organization(GO:1902905) |
| 1.7 | 3.3 | GO:0006404 | RNA import into nucleus(GO:0006404) |
| 1.7 | 13.2 | GO:0009052 | pentose-phosphate shunt, non-oxidative branch(GO:0009052) |
| 1.6 | 136.1 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 1.6 | 24.5 | GO:0000338 | protein deneddylation(GO:0000338) |
| 1.6 | 6.5 | GO:0003409 | optic cup structural organization(GO:0003409) |
| 1.6 | 9.7 | GO:0035965 | cardiolipin acyl-chain remodeling(GO:0035965) |
| 1.6 | 6.4 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 1.6 | 19.1 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
| 1.6 | 7.8 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 1.6 | 3.1 | GO:0090169 | regulation of spindle assembly(GO:0090169) |
| 1.5 | 6.2 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 1.5 | 13.8 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
| 1.5 | 6.1 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 1.5 | 4.5 | GO:0031064 | negative regulation of histone deacetylation(GO:0031064) |
| 1.5 | 10.5 | GO:1905123 | regulation of glucosylceramidase activity(GO:1905123) |
| 1.5 | 3.0 | GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562) |
| 1.5 | 8.8 | GO:0006591 | ornithine metabolic process(GO:0006591) |
| 1.5 | 60.9 | GO:0006294 | nucleotide-excision repair, preincision complex assembly(GO:0006294) |
| 1.4 | 8.6 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 1.4 | 7.1 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 1.4 | 14.3 | GO:1903421 | regulation of synaptic vesicle recycling(GO:1903421) |
| 1.4 | 12.8 | GO:0048069 | eye pigmentation(GO:0048069) |
| 1.4 | 5.7 | GO:0032099 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
| 1.4 | 18.4 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.4 | 49.2 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 1.4 | 16.8 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 1.4 | 8.4 | GO:0045079 | negative regulation of chemokine biosynthetic process(GO:0045079) |
| 1.4 | 8.4 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 1.4 | 8.3 | GO:0017182 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 1.4 | 5.5 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 1.4 | 2.7 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 1.3 | 6.7 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 1.3 | 34.6 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 1.3 | 8.0 | GO:0032506 | cytokinetic process(GO:0032506) |
| 1.3 | 5.2 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 1.3 | 9.1 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 1.3 | 11.7 | GO:0042262 | DNA protection(GO:0042262) |
| 1.3 | 7.7 | GO:0002934 | desmosome organization(GO:0002934) |
| 1.3 | 5.1 | GO:0019418 | sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221) |
| 1.3 | 11.4 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 1.3 | 10.1 | GO:0009130 | pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) |
| 1.3 | 21.4 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
| 1.2 | 86.0 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 1.2 | 2.5 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 1.2 | 24.6 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 1.2 | 12.2 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 1.2 | 7.2 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 1.2 | 19.0 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 1.2 | 5.8 | GO:0098902 | regulation of membrane depolarization during action potential(GO:0098902) |
| 1.1 | 38.5 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 1.1 | 1.1 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 1.1 | 8.9 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 1.1 | 8.8 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 1.1 | 34.2 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 1.1 | 17.3 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 1.1 | 15.1 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 1.1 | 11.9 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 1.1 | 41.9 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 1.1 | 29.9 | GO:0002183 | cytoplasmic translational initiation(GO:0002183) |
| 1.0 | 6.3 | GO:0006264 | mitochondrial DNA replication(GO:0006264) |
| 1.0 | 5.2 | GO:0061738 | late endosomal microautophagy(GO:0061738) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 1.0 | 5.2 | GO:0038108 | negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019) |
| 1.0 | 12.4 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 1.0 | 2.0 | GO:0006550 | isoleucine catabolic process(GO:0006550) |
| 1.0 | 8.1 | GO:0035524 | proline transmembrane transport(GO:0035524) |
| 1.0 | 3.0 | GO:0019532 | oxalate transport(GO:0019532) dipeptide transport(GO:0042938) |
| 1.0 | 3.0 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 1.0 | 5.0 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 1.0 | 16.9 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 1.0 | 15.8 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 1.0 | 3.0 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 1.0 | 15.7 | GO:0031167 | rRNA methylation(GO:0031167) |
| 1.0 | 5.9 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 1.0 | 6.8 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 1.0 | 8.6 | GO:0046689 | response to mercury ion(GO:0046689) |
| 1.0 | 7.7 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 1.0 | 18.2 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 1.0 | 3.8 | GO:2000354 | regulation of ovarian follicle development(GO:2000354) |
| 0.9 | 2.8 | GO:0036510 | trimming of terminal mannose on C branch(GO:0036510) |
| 0.9 | 1.9 | GO:1901355 | response to rapamycin(GO:1901355) |
| 0.9 | 13.1 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.9 | 2.7 | GO:0019401 | alditol biosynthetic process(GO:0019401) |
| 0.9 | 3.6 | GO:1904977 | lymphatic endothelial cell migration(GO:1904977) |
| 0.9 | 10.9 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.9 | 7.1 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 0.9 | 280.9 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 0.9 | 12.4 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.9 | 22.0 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.9 | 11.3 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.9 | 38.7 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.9 | 25.8 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.9 | 3.4 | GO:0031179 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 0.8 | 3.3 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.8 | 33.6 | GO:0000070 | mitotic sister chromatid segregation(GO:0000070) |
| 0.8 | 2.4 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.8 | 2.4 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.8 | 3.2 | GO:0035814 | negative regulation of urine volume(GO:0035811) negative regulation of renal sodium excretion(GO:0035814) |
| 0.8 | 4.8 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.8 | 16.0 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.8 | 24.5 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.8 | 3.9 | GO:0006668 | sphinganine-1-phosphate metabolic process(GO:0006668) |
| 0.8 | 35.3 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.8 | 3.9 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.8 | 3.1 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.8 | 4.5 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.8 | 1.5 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.7 | 3.7 | GO:0043128 | regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128) |
| 0.7 | 6.6 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.7 | 4.4 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.7 | 10.2 | GO:0051024 | positive regulation of immunoglobulin secretion(GO:0051024) |
| 0.7 | 8.7 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.7 | 7.2 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.7 | 15.7 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.7 | 12.7 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.7 | 2.8 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
| 0.7 | 6.2 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 0.7 | 2.0 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
| 0.7 | 8.8 | GO:0032310 | prostaglandin secretion(GO:0032310) |
| 0.7 | 18.0 | GO:1903205 | regulation of hydrogen peroxide-induced cell death(GO:1903205) |
| 0.7 | 10.0 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.7 | 1.3 | GO:0040031 | snRNA modification(GO:0040031) |
| 0.7 | 0.7 | GO:1904432 | antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) response to iron(III) ion(GO:0010041) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) cellular response to iron(III) ion(GO:0071283) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) |
| 0.7 | 17.8 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.7 | 2.6 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.7 | 8.5 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949) |
| 0.6 | 11.0 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.6 | 7.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.6 | 3.2 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.6 | 3.2 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.6 | 8.1 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.6 | 9.8 | GO:0040032 | parathyroid hormone secretion(GO:0035898) post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828) |
| 0.6 | 1.8 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.6 | 6.7 | GO:1904322 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.6 | 6.1 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.6 | 68.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.6 | 1.8 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.6 | 4.2 | GO:0071352 | interleukin-2-mediated signaling pathway(GO:0038110) cellular response to interleukin-2(GO:0071352) |
| 0.6 | 4.1 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.6 | 24.6 | GO:0008033 | tRNA processing(GO:0008033) |
| 0.6 | 5.8 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.6 | 22.0 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.6 | 3.4 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.6 | 5.6 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.5 | 18.7 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.5 | 7.6 | GO:0036109 | alpha-linolenic acid metabolic process(GO:0036109) |
| 0.5 | 30.7 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.5 | 2.6 | GO:0009048 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.5 | 17.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.5 | 24.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.5 | 5.5 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.5 | 4.0 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.5 | 57.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.5 | 3.4 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.5 | 12.6 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.5 | 11.6 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 0.5 | 12.5 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.5 | 15.8 | GO:0043496 | regulation of protein homodimerization activity(GO:0043496) |
| 0.5 | 6.0 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.5 | 29.7 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.4 | 5.8 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.4 | 3.9 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.4 | 3.4 | GO:0060413 | atrial septum morphogenesis(GO:0060413) |
| 0.4 | 10.1 | GO:0006289 | nucleotide-excision repair(GO:0006289) |
| 0.4 | 6.3 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.4 | 2.4 | GO:0006549 | isoleucine metabolic process(GO:0006549) |
| 0.4 | 2.0 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) |
| 0.4 | 6.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.4 | 9.1 | GO:0006378 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 0.4 | 2.0 | GO:0048840 | otolith development(GO:0048840) |
| 0.4 | 0.4 | GO:0032423 | regulation of mismatch repair(GO:0032423) positive regulation of mismatch repair(GO:0032425) |
| 0.4 | 12.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.4 | 0.8 | GO:0046222 | mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376) |
| 0.4 | 4.2 | GO:0061001 | regulation of dendritic spine morphogenesis(GO:0061001) |
| 0.4 | 17.2 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.3 | 12.4 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.3 | 10.9 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.3 | 9.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 3.1 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.3 | 3.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.3 | 2.0 | GO:0061767 | negative regulation of cardiac muscle adaptation(GO:0010616) positive regulation of transforming growth factor beta3 production(GO:0032916) negative regulation of lung blood pressure(GO:0061767) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243) |
| 0.3 | 2.6 | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.3 | 8.9 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.3 | 6.3 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.3 | 1.9 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.3 | 26.5 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.3 | 8.1 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.3 | 2.1 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.3 | 6.0 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.3 | 4.3 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
| 0.3 | 12.2 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.3 | 2.0 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.3 | 3.9 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.3 | 31.7 | GO:0031424 | keratinization(GO:0031424) |
| 0.3 | 2.1 | GO:0009597 | detection of virus(GO:0009597) |
| 0.3 | 3.6 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.3 | 0.5 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.3 | 3.6 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.3 | 2.8 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.2 | 5.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.2 | 16.8 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.2 | 3.9 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.2 | 0.7 | GO:0010626 | regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.2 | 4.2 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.2 | 1.2 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.2 | 1.6 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.2 | 4.4 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.2 | 19.6 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.2 | 0.6 | GO:1904058 | positive regulation of sensory perception of pain(GO:1904058) |
| 0.2 | 13.6 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.2 | 3.3 | GO:1900037 | regulation of cellular response to hypoxia(GO:1900037) |
| 0.2 | 0.4 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.2 | 2.1 | GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254) |
| 0.2 | 7.6 | GO:0045333 | cellular respiration(GO:0045333) |
| 0.2 | 0.5 | GO:0042137 | sequestering of neurotransmitter(GO:0042137) |
| 0.2 | 2.1 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 0.3 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.2 | 2.6 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.2 | 7.3 | GO:0010595 | positive regulation of endothelial cell migration(GO:0010595) |
| 0.2 | 1.4 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.2 | 0.8 | GO:0046654 | tetrahydrofolate biosynthetic process(GO:0046654) |
| 0.2 | 3.7 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.1 | 0.7 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.1 | 3.2 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.1 | 1.7 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.1 | 0.3 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.1 | 4.8 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 3.8 | GO:0050766 | positive regulation of phagocytosis(GO:0050766) |
| 0.1 | 0.2 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.1 | 1.0 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 0.7 | GO:1990592 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.1 | 1.7 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 9.7 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.1 | 1.0 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.1 | 3.8 | GO:0090003 | regulation of establishment of protein localization to plasma membrane(GO:0090003) |
| 0.1 | 0.2 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.1 | 0.5 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 0.1 | 3.3 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) |
| 0.1 | 1.0 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.1 | 1.3 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 0.2 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 0.1 | 1.2 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 2.1 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 0.4 | GO:0061205 | nose morphogenesis(GO:0043585) alveolar primary septum development(GO:0061143) paramesonephric duct development(GO:0061205) |
| 0.1 | 2.3 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.1 | 0.3 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.1 | 1.6 | GO:0006414 | translational elongation(GO:0006414) |
| 0.1 | 0.3 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.0 | 1.3 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation(GO:0033137) |
| 0.0 | 0.9 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 0.0 | 0.8 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.0 | 3.6 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.5 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 0.1 | GO:0071888 | macrophage apoptotic process(GO:0071888) |
| 0.0 | 0.2 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.1 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.3 | 20.3 | GO:0031261 | nuclear pre-replicative complex(GO:0005656) DNA replication preinitiation complex(GO:0031261) pre-replicative complex(GO:0036387) |
| 19.2 | 153.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 18.5 | 55.5 | GO:0033597 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 17.4 | 156.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 17.1 | 68.5 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 16.0 | 64.0 | GO:0000811 | GINS complex(GO:0000811) |
| 15.0 | 59.8 | GO:1990356 | sumoylated E2 ligase complex(GO:1990356) |
| 14.6 | 43.9 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 13.1 | 91.4 | GO:0090661 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 12.6 | 352.3 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 11.4 | 34.3 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 10.6 | 53.0 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 9.1 | 36.4 | GO:1990423 | RZZ complex(GO:1990423) |
| 8.7 | 43.4 | GO:0031523 | Myb complex(GO:0031523) |
| 7.8 | 93.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 7.8 | 38.8 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 7.6 | 30.2 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 7.5 | 82.9 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 7.4 | 44.6 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 7.4 | 29.6 | GO:0071942 | XPC complex(GO:0071942) |
| 7.1 | 28.4 | GO:0071920 | cleavage body(GO:0071920) |
| 6.6 | 19.8 | GO:0030689 | Noc complex(GO:0030689) |
| 6.4 | 32.0 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 6.3 | 37.6 | GO:0061617 | MICOS complex(GO:0061617) |
| 6.2 | 43.1 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 5.8 | 299.0 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 5.7 | 23.0 | GO:0035363 | histone locus body(GO:0035363) |
| 5.7 | 28.3 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 5.5 | 71.7 | GO:0005688 | U6 snRNP(GO:0005688) |
| 5.5 | 22.0 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 5.4 | 75.3 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 5.2 | 15.5 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 5.1 | 15.2 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 5.1 | 81.1 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 4.9 | 49.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 4.8 | 38.3 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 4.8 | 76.0 | GO:0045120 | pronucleus(GO:0045120) |
| 4.7 | 66.3 | GO:0070938 | contractile ring(GO:0070938) |
| 4.6 | 77.4 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 4.4 | 22.1 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 4.4 | 39.7 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 4.4 | 39.5 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 4.3 | 17.3 | GO:1990246 | uniplex complex(GO:1990246) |
| 4.2 | 21.1 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 4.2 | 21.0 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 4.2 | 12.6 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) Ndc80 complex(GO:0031262) |
| 4.1 | 41.5 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 4.1 | 16.4 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 4.0 | 48.5 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 4.0 | 12.1 | GO:0034677 | integrin alpha7-beta1 complex(GO:0034677) |
| 4.0 | 40.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 4.0 | 15.9 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 3.9 | 50.7 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 3.6 | 28.6 | GO:0031931 | TORC1 complex(GO:0031931) |
| 3.4 | 3.4 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 3.4 | 13.5 | GO:0070876 | SOSS complex(GO:0070876) |
| 3.4 | 47.0 | GO:0001741 | XY body(GO:0001741) |
| 3.3 | 20.1 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 3.3 | 16.4 | GO:0001651 | dense fibrillar component(GO:0001651) granular component(GO:0001652) |
| 3.3 | 13.1 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 3.2 | 6.4 | GO:1903349 | omegasome membrane(GO:1903349) |
| 3.1 | 27.9 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 3.1 | 9.3 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 3.1 | 196.9 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 3.1 | 33.8 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 3.1 | 15.3 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 3.0 | 307.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.9 | 14.4 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 2.9 | 14.3 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 2.9 | 59.9 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 2.8 | 16.5 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 2.7 | 13.7 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 2.7 | 58.8 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 2.6 | 34.3 | GO:0042555 | MCM complex(GO:0042555) |
| 2.6 | 21.1 | GO:0000796 | condensin complex(GO:0000796) |
| 2.6 | 5.2 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 2.5 | 12.6 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 2.5 | 25.2 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 2.5 | 7.5 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 2.5 | 12.4 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
| 2.4 | 7.2 | GO:0018444 | translation release factor complex(GO:0018444) |
| 2.3 | 16.3 | GO:1990635 | proximal dendrite(GO:1990635) |
| 2.2 | 29.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 2.2 | 71.2 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 2.2 | 19.8 | GO:0005732 | small nucleolar ribonucleoprotein complex(GO:0005732) |
| 2.2 | 32.9 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 2.2 | 6.6 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 2.2 | 6.6 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 2.2 | 19.6 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 2.1 | 14.8 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 2.1 | 22.7 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 2.1 | 14.4 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 2.0 | 6.1 | GO:0000939 | condensed chromosome inner kinetochore(GO:0000939) |
| 2.0 | 14.2 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 2.0 | 14.2 | GO:0016272 | prefoldin complex(GO:0016272) |
| 2.0 | 38.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 2.0 | 18.0 | GO:1990630 | IRE1-RACK1-PP2A complex(GO:1990630) |
| 2.0 | 32.0 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 1.9 | 9.7 | GO:0016589 | NURF complex(GO:0016589) |
| 1.9 | 7.7 | GO:0036452 | ESCRT complex(GO:0036452) |
| 1.9 | 11.6 | GO:0005839 | proteasome core complex(GO:0005839) |
| 1.9 | 45.7 | GO:0016469 | proton-transporting two-sector ATPase complex(GO:0016469) |
| 1.9 | 9.5 | GO:0042825 | TAP complex(GO:0042825) |
| 1.9 | 50.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 1.9 | 9.4 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 1.9 | 9.3 | GO:0097422 | tubular endosome(GO:0097422) |
| 1.8 | 3.7 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 1.8 | 23.9 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 1.8 | 71.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 1.8 | 16.2 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 1.8 | 57.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 1.8 | 17.8 | GO:0051286 | cell tip(GO:0051286) |
| 1.7 | 12.2 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 1.7 | 38.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 1.7 | 5.2 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 1.7 | 33.8 | GO:0030686 | 90S preribosome(GO:0030686) |
| 1.7 | 16.9 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 1.7 | 65.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.7 | 30.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 1.6 | 28.8 | GO:0032433 | filopodium tip(GO:0032433) |
| 1.6 | 14.4 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 1.6 | 17.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 1.6 | 15.5 | GO:0010369 | chromocenter(GO:0010369) |
| 1.5 | 9.2 | GO:0090543 | Flemming body(GO:0090543) |
| 1.5 | 10.6 | GO:0031371 | ubiquitin conjugating enzyme complex(GO:0031371) |
| 1.5 | 12.0 | GO:0070652 | HAUS complex(GO:0070652) |
| 1.5 | 25.2 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 1.5 | 7.4 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 1.5 | 17.5 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 1.5 | 7.3 | GO:0089701 | U2AF(GO:0089701) |
| 1.5 | 7.3 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 1.4 | 17.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 1.4 | 7.1 | GO:0044327 | dendritic spine head(GO:0044327) |
| 1.4 | 48.2 | GO:0000502 | proteasome complex(GO:0000502) |
| 1.4 | 28.3 | GO:0005686 | U2 snRNP(GO:0005686) |
| 1.4 | 12.6 | GO:0042382 | paraspeckles(GO:0042382) |
| 1.4 | 25.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 1.4 | 42.2 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 1.3 | 14.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.3 | 101.6 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 1.3 | 17.1 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 1.3 | 76.0 | GO:0005876 | spindle microtubule(GO:0005876) |
| 1.3 | 10.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 1.3 | 37.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 1.3 | 6.4 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 1.3 | 2.6 | GO:0000805 | X chromosome(GO:0000805) |
| 1.3 | 21.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 1.3 | 8.8 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 1.2 | 2.4 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 1.2 | 31.6 | GO:0031264 | death-inducing signaling complex(GO:0031264) |
| 1.2 | 9.5 | GO:0008274 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 1.2 | 13.1 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 1.2 | 9.3 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 1.2 | 48.8 | GO:0045095 | keratin filament(GO:0045095) |
| 1.2 | 8.1 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 1.1 | 12.0 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 1.1 | 17.3 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 1.0 | 4.0 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 1.0 | 4.9 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 1.0 | 4.9 | GO:0035061 | interchromatin granule(GO:0035061) |
| 1.0 | 7.8 | GO:0097526 | U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526) |
| 1.0 | 15.5 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.9 | 155.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.9 | 12.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.9 | 7.4 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.9 | 11.0 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.9 | 9.0 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.9 | 9.9 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.9 | 4.4 | GO:0032044 | DSIF complex(GO:0032044) |
| 0.9 | 30.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.9 | 11.4 | GO:0033202 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.9 | 12.2 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.9 | 10.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.9 | 14.6 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.8 | 2.4 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.8 | 0.8 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.8 | 17.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.8 | 8.7 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.8 | 9.4 | GO:0071203 | WASH complex(GO:0071203) |
| 0.8 | 16.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.7 | 35.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.7 | 16.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.7 | 21.1 | GO:0030057 | desmosome(GO:0030057) |
| 0.7 | 32.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.7 | 13.0 | GO:0000776 | kinetochore(GO:0000776) |
| 0.7 | 10.9 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.7 | 6.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.7 | 2.6 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.6 | 18.0 | GO:0005844 | polysome(GO:0005844) |
| 0.6 | 46.2 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.6 | 6.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.6 | 1.9 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.6 | 20.1 | GO:0032592 | integral component of mitochondrial membrane(GO:0032592) |
| 0.6 | 1.8 | GO:0035517 | PR-DUB complex(GO:0035517) |
| 0.6 | 32.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.6 | 11.8 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.6 | 3.5 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.6 | 88.1 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.6 | 9.9 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.5 | 4.9 | GO:0000938 | GARP complex(GO:0000938) |
| 0.5 | 10.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.5 | 205.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.5 | 5.5 | GO:0097433 | dense body(GO:0097433) |
| 0.5 | 7.4 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.5 | 17.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.5 | 4.5 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.4 | 3.6 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.4 | 15.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.4 | 1.3 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.4 | 4.6 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.4 | 11.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.4 | 8.2 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.4 | 1.9 | GO:0031673 | H zone(GO:0031673) |
| 0.4 | 5.5 | GO:0032059 | bleb(GO:0032059) |
| 0.4 | 142.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.4 | 24.0 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.4 | 0.7 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.4 | 2.8 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.3 | 20.1 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.3 | 56.3 | GO:0031968 | organelle outer membrane(GO:0031968) |
| 0.3 | 9.1 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.3 | 5.0 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.3 | 8.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.3 | 10.6 | GO:0002102 | podosome(GO:0002102) |
| 0.3 | 2.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 22.3 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.3 | 19.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.3 | 3.1 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.3 | 6.9 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.3 | 7.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 248.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 2.9 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.2 | 3.5 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.2 | 2.0 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.2 | 18.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 6.1 | GO:0071564 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.2 | 8.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 20.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 1.1 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 34.6 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.2 | 13.4 | GO:0005840 | ribosome(GO:0005840) |
| 0.2 | 1.0 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.2 | 6.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.2 | 5.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 0.7 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 17.4 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.1 | 1.0 | GO:0031932 | TORC2 complex(GO:0031932) TOR complex(GO:0038201) |
| 0.1 | 26.0 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 16.6 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.1 | 5.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.1 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.0 | 0.6 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.0 | 1.5 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 8.2 | GO:0005730 | nucleolus(GO:0005730) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 23.1 | 69.2 | GO:0004170 | dUTP diphosphatase activity(GO:0004170) |
| 19.2 | 153.9 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 18.9 | 75.7 | GO:0004146 | dihydrofolate reductase activity(GO:0004146) |
| 15.9 | 47.8 | GO:0070991 | medium-chain-acyl-CoA dehydrogenase activity(GO:0070991) |
| 15.0 | 59.8 | GO:0061656 | SUMO conjugating enzyme activity(GO:0061656) |
| 14.6 | 43.7 | GO:0008988 | rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) |
| 13.7 | 54.9 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) |
| 13.1 | 91.4 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 11.8 | 35.3 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
| 11.6 | 46.5 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 10.7 | 10.7 | GO:0004651 | polynucleotide 5'-phosphatase activity(GO:0004651) |
| 10.3 | 30.9 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 10.3 | 10.3 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 10.2 | 40.9 | GO:0070404 | NADH binding(GO:0070404) |
| 9.9 | 29.6 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 9.8 | 49.2 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 9.8 | 39.1 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 9.6 | 57.4 | GO:0044388 | small protein activating enzyme binding(GO:0044388) |
| 9.3 | 27.9 | GO:0080023 | 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023) |
| 9.2 | 46.2 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 9.2 | 27.7 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
| 9.0 | 36.1 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 8.7 | 26.1 | GO:0031403 | lithium ion binding(GO:0031403) |
| 8.4 | 25.1 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 8.3 | 33.3 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 8.2 | 32.7 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 7.9 | 31.8 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 7.9 | 31.8 | GO:0002060 | purine nucleobase binding(GO:0002060) |
| 7.8 | 38.8 | GO:0000104 | succinate dehydrogenase activity(GO:0000104) |
| 7.7 | 23.1 | GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) |
| 7.7 | 30.7 | GO:0047676 | arachidonate-CoA ligase activity(GO:0047676) |
| 7.6 | 30.2 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 7.4 | 29.8 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 7.1 | 28.4 | GO:0033677 | DNA/RNA helicase activity(GO:0033677) |
| 7.0 | 21.0 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
| 6.5 | 32.7 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 6.5 | 19.6 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 6.3 | 63.5 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 6.3 | 19.0 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 6.1 | 24.6 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 6.1 | 24.5 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 6.0 | 18.1 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 6.0 | 168.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 6.0 | 18.0 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 6.0 | 53.6 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 5.9 | 17.8 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 5.9 | 17.7 | GO:0016784 | 3-mercaptopyruvate sulfurtransferase activity(GO:0016784) |
| 5.8 | 63.8 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 5.8 | 69.2 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 5.6 | 33.8 | GO:0030620 | U2 snRNA binding(GO:0030620) |
| 5.6 | 61.8 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 5.6 | 22.5 | GO:0015207 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 5.6 | 73.0 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 5.6 | 39.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 5.5 | 27.7 | GO:0050610 | glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
| 5.2 | 52.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 5.2 | 15.6 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 5.1 | 36.0 | GO:0004457 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 5.1 | 5.1 | GO:0016672 | oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) |
| 5.0 | 24.8 | GO:0008263 | pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263) |
| 4.9 | 29.1 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 4.8 | 19.4 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 4.8 | 53.2 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 4.8 | 19.3 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 4.8 | 86.8 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 4.8 | 14.4 | GO:0033699 | DNA 5'-adenosine monophosphate hydrolase activity(GO:0033699) |
| 4.8 | 57.2 | GO:0031386 | protein tag(GO:0031386) |
| 4.8 | 14.3 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 4.7 | 18.7 | GO:0070363 | mitochondrial light strand promoter sense binding(GO:0070363) |
| 4.6 | 13.9 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 4.6 | 41.5 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 4.6 | 18.3 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 4.6 | 22.9 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 4.5 | 63.4 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 4.5 | 13.6 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 4.5 | 13.4 | GO:0004566 | beta-glucuronidase activity(GO:0004566) |
| 4.5 | 13.4 | GO:0004056 | argininosuccinate lyase activity(GO:0004056) |
| 4.4 | 26.5 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
| 4.4 | 26.4 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 4.4 | 39.5 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 4.4 | 21.8 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 4.3 | 43.0 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 4.3 | 21.4 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 4.2 | 8.4 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 4.2 | 12.6 | GO:0009032 | thymidine phosphorylase activity(GO:0009032) pyrimidine-nucleoside phosphorylase activity(GO:0016154) |
| 4.1 | 12.2 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 4.0 | 12.1 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 4.0 | 71.7 | GO:0035173 | histone kinase activity(GO:0035173) |
| 3.9 | 23.4 | GO:0016435 | rRNA (guanine) methyltransferase activity(GO:0016435) |
| 3.9 | 11.7 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 3.9 | 11.6 | GO:0070704 | C-5 sterol desaturase activity(GO:0000248) sterol desaturase activity(GO:0070704) |
| 3.9 | 61.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 3.8 | 30.5 | GO:0015288 | porin activity(GO:0015288) |
| 3.7 | 15.0 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 3.7 | 11.2 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
| 3.6 | 43.6 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 3.6 | 21.7 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 3.6 | 14.3 | GO:0102345 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 3.6 | 14.2 | GO:0097506 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 3.5 | 21.2 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 3.3 | 13.3 | GO:0001512 | dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408) |
| 3.3 | 36.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 3.3 | 9.8 | GO:0000773 | phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101) |
| 3.3 | 35.8 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 3.2 | 9.7 | GO:0055100 | adiponectin binding(GO:0055100) |
| 3.2 | 6.4 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 3.2 | 22.1 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 3.1 | 55.8 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 3.0 | 12.2 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 3.0 | 12.1 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 3.0 | 90.0 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 3.0 | 630.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.9 | 156.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 2.9 | 14.7 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 2.9 | 17.3 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 2.9 | 8.7 | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity(GO:0003860) |
| 2.9 | 11.4 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 2.8 | 14.1 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 2.8 | 16.8 | GO:0036033 | mediator complex binding(GO:0036033) |
| 2.8 | 8.4 | GO:1903135 | cupric ion binding(GO:1903135) |
| 2.8 | 22.1 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 2.7 | 35.5 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 2.7 | 8.2 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 2.7 | 13.6 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 2.7 | 29.7 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 2.6 | 70.5 | GO:0048156 | tau protein binding(GO:0048156) |
| 2.6 | 23.5 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 2.6 | 15.6 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 2.6 | 28.3 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 2.5 | 12.6 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 2.5 | 7.6 | GO:0015137 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 2.5 | 12.6 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
| 2.5 | 15.0 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 2.5 | 27.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 2.4 | 7.3 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 2.4 | 53.4 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 2.4 | 36.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 2.4 | 50.3 | GO:0070878 | primary miRNA binding(GO:0070878) |
| 2.4 | 12.0 | GO:0004471 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948) |
| 2.3 | 30.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 2.3 | 9.4 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 2.3 | 28.0 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 2.3 | 23.3 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 2.3 | 14.0 | GO:0015266 | protein channel activity(GO:0015266) |
| 2.3 | 11.5 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 2.2 | 22.2 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 2.2 | 6.7 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 2.2 | 26.6 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 2.1 | 27.7 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 2.1 | 52.9 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 2.0 | 2.0 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 2.0 | 2.0 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 2.0 | 10.0 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 2.0 | 4.0 | GO:0043682 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 2.0 | 9.9 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 2.0 | 7.9 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 2.0 | 46.9 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 1.9 | 19.1 | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242) |
| 1.9 | 22.9 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 1.9 | 11.4 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 1.9 | 58.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 1.9 | 9.5 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) |
| 1.9 | 9.4 | GO:1990254 | keratin filament binding(GO:1990254) |
| 1.9 | 5.6 | GO:0034736 | sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736) |
| 1.9 | 14.8 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 1.8 | 5.5 | GO:0098918 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 1.8 | 25.8 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 1.8 | 12.9 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 1.8 | 21.9 | GO:0031404 | chloride ion binding(GO:0031404) |
| 1.8 | 7.3 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 1.8 | 9.0 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 1.8 | 23.3 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 1.8 | 202.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.8 | 8.9 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 1.8 | 15.8 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 1.7 | 15.6 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 1.7 | 6.9 | GO:0050211 | procollagen galactosyltransferase activity(GO:0050211) |
| 1.7 | 19.0 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 1.7 | 10.3 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 1.7 | 13.4 | GO:0030911 | TPR domain binding(GO:0030911) |
| 1.7 | 14.9 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 1.6 | 3.3 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 1.6 | 13.1 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 1.6 | 57.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 1.6 | 62.0 | GO:0005123 | death receptor binding(GO:0005123) |
| 1.6 | 9.5 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 1.6 | 17.1 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) |
| 1.5 | 15.5 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 1.5 | 107.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.5 | 9.1 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 1.5 | 10.5 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 1.5 | 7.4 | GO:0004161 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 1.5 | 11.7 | GO:0050733 | RS domain binding(GO:0050733) |
| 1.5 | 14.7 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 1.4 | 23.0 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 1.4 | 7.2 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 1.4 | 8.6 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 1.4 | 39.6 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 1.4 | 7.0 | GO:0004082 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 1.4 | 8.4 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 1.4 | 29.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 1.4 | 18.2 | GO:0016840 | carbon-nitrogen lyase activity(GO:0016840) |
| 1.4 | 19.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 1.4 | 12.3 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 1.4 | 24.5 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 1.4 | 12.2 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 1.3 | 12.1 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 1.3 | 12.1 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 1.3 | 10.7 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 1.3 | 4.0 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 1.3 | 6.6 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 1.3 | 34.2 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 1.3 | 34.9 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 1.3 | 29.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 1.3 | 33.0 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 1.3 | 21.5 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 1.3 | 3.8 | GO:0034046 | poly(G) binding(GO:0034046) |
| 1.3 | 37.7 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 1.2 | 8.7 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 1.2 | 3.6 | GO:0033858 | N-acetylgalactosamine kinase activity(GO:0033858) |
| 1.2 | 7.3 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 1.2 | 3.6 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 1.2 | 7.2 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 1.2 | 9.5 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 1.2 | 2.3 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 1.1 | 14.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.1 | 20.5 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 1.1 | 29.1 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 1.1 | 8.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 1.1 | 56.2 | GO:0031491 | nucleosome binding(GO:0031491) |
| 1.1 | 4.4 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 1.1 | 7.6 | GO:0052832 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 1.1 | 38.7 | GO:0008143 | poly(A) binding(GO:0008143) |
| 1.0 | 6.3 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 1.0 | 8.4 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 1.0 | 53.0 | GO:0019894 | kinesin binding(GO:0019894) |
| 1.0 | 12.4 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 1.0 | 11.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 1.0 | 8.1 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 1.0 | 8.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 1.0 | 7.0 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 1.0 | 10.0 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 1.0 | 18.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 1.0 | 54.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.0 | 51.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 1.0 | 7.7 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 1.0 | 10.6 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 1.0 | 3.8 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 1.0 | 5.8 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 1.0 | 4.8 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.9 | 15.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.9 | 25.6 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.9 | 4.5 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.9 | 0.9 | GO:0016419 | [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420) |
| 0.9 | 17.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.9 | 38.4 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.9 | 6.0 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.8 | 14.3 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.8 | 4.2 | GO:0008410 | CoA-transferase activity(GO:0008410) |
| 0.8 | 11.7 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.8 | 5.8 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.8 | 14.0 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
| 0.8 | 16.3 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.8 | 2.4 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.8 | 17.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.8 | 30.8 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.8 | 16.9 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.8 | 6.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.8 | 16.7 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.8 | 7.1 | GO:0050145 | nucleoside phosphate kinase activity(GO:0050145) |
| 0.8 | 11.0 | GO:0043495 | protein anchor(GO:0043495) |
| 0.8 | 17.2 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.8 | 48.4 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.8 | 9.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.8 | 79.1 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.7 | 3.0 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.7 | 18.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.7 | 3.7 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.7 | 4.3 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.7 | 7.1 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.7 | 7.7 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.7 | 4.2 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.7 | 12.7 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.7 | 35.3 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.7 | 11.8 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.7 | 3.9 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.6 | 3.2 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
| 0.6 | 14.7 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.6 | 19.1 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
| 0.6 | 2.4 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.6 | 26.3 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.6 | 1.7 | GO:0047223 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223) |
| 0.6 | 9.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.6 | 3.4 | GO:0038049 | transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) |
| 0.6 | 4.6 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.6 | 3.4 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.6 | 26.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.6 | 33.9 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.5 | 4.8 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.5 | 6.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.5 | 1.6 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.5 | 19.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.5 | 2.0 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.5 | 6.8 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.5 | 2.4 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.5 | 31.5 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.5 | 13.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.5 | 5.7 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.5 | 2.8 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.5 | 9.9 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.5 | 8.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.5 | 3.2 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.5 | 4.1 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.4 | 2.7 | GO:0008381 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.4 | 6.9 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.4 | 5.1 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.4 | 7.1 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.4 | 6.3 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.4 | 26.4 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.4 | 2.8 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.4 | 2.0 | GO:0052656 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.4 | 3.2 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
| 0.4 | 10.5 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617) |
| 0.4 | 5.2 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.4 | 17.4 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.4 | 4.3 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.4 | 5.8 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.4 | 4.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.4 | 3.1 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.4 | 6.8 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.4 | 8.5 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.4 | 36.2 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.4 | 2.8 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.3 | 58.0 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.3 | 12.7 | GO:0032451 | demethylase activity(GO:0032451) |
| 0.3 | 14.6 | GO:0061650 | ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.3 | 112.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.3 | 0.7 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.3 | 39.7 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.3 | 3.9 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.3 | 3.2 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.3 | 8.2 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.3 | 13.5 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.3 | 1.5 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.3 | 10.8 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.3 | 1.2 | GO:0070513 | death domain binding(GO:0070513) |
| 0.3 | 13.2 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.3 | 12.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.3 | 3.4 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.3 | 8.6 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.3 | 5.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.3 | 42.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 2.1 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.3 | 1.5 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.2 | 8.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.2 | 8.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 1.1 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.2 | 2.1 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.2 | 1.6 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.2 | 0.8 | GO:0033897 | ribonuclease T2 activity(GO:0033897) |
| 0.2 | 0.8 | GO:0016742 | hydroxymethyl-, formyl- and related transferase activity(GO:0016742) |
| 0.2 | 4.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 5.2 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.2 | 10.9 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.2 | 1.4 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 2.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 1.1 | GO:0030228 | low-density lipoprotein receptor activity(GO:0005041) lipoprotein particle receptor activity(GO:0030228) |
| 0.1 | 3.8 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 0.5 | GO:0015222 | serotonin transmembrane transporter activity(GO:0015222) |
| 0.1 | 3.3 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 1.6 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.1 | 5.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 1.3 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 1.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 87.0 | GO:0003723 | RNA binding(GO:0003723) |
| 0.1 | 3.2 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 3.4 | GO:0004950 | G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950) |
| 0.1 | 0.6 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 1.3 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.1 | 0.3 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.1 | 1.7 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 0.3 | GO:0005497 | androgen binding(GO:0005497) |
| 0.1 | 1.1 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 0.5 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.1 | GO:0036505 | prosaposin receptor activity(GO:0036505) |
| 0.0 | 0.3 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 0.8 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 1.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 1.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 99.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 3.5 | 81.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 3.4 | 99.0 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 3.1 | 9.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 2.6 | 102.8 | PID ATM PATHWAY | ATM pathway |
| 2.4 | 346.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.1 | 135.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 2.0 | 81.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 1.9 | 73.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 1.6 | 12.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 1.4 | 26.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 1.4 | 57.3 | PID ATR PATHWAY | ATR signaling pathway |
| 1.3 | 23.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 1.2 | 108.5 | PID E2F PATHWAY | E2F transcription factor network |
| 1.2 | 49.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.1 | 38.2 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 1.1 | 4.3 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 1.0 | 72.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.9 | 63.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.9 | 7.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.8 | 32.9 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.8 | 8.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.7 | 30.4 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.7 | 47.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.7 | 24.2 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.7 | 58.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.7 | 8.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.6 | 17.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.6 | 16.4 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.6 | 3.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.6 | 5.3 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.6 | 24.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.6 | 6.8 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.6 | 10.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.6 | 9.5 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.5 | 52.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.5 | 21.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.5 | 27.1 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.5 | 26.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.5 | 6.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.5 | 23.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.5 | 24.1 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.5 | 2.9 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.4 | 8.4 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.4 | 10.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.4 | 16.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 16.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 18.0 | PID P73PATHWAY | p73 transcription factor network |
| 0.3 | 6.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 11.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.3 | 2.3 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.3 | 0.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 7.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.2 | 10.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 4.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.2 | 6.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 13.0 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.2 | 2.7 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 2.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 2.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 30.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 8.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 6.3 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 1.0 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 2.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 3.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 3.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 3.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 3.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.3 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.4 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 0.1 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 104.9 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 7.6 | 144.8 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 6.8 | 115.7 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 6.7 | 100.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 4.9 | 187.8 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 4.5 | 31.8 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 4.5 | 154.2 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 4.4 | 65.8 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 4.2 | 237.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 4.1 | 297.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 4.0 | 27.7 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 3.8 | 120.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 3.7 | 54.9 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 3.4 | 154.7 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 3.3 | 92.6 | REACTOME GLOBAL GENOMIC NER GG NER | Genes involved in Global Genomic NER (GG-NER) |
| 3.1 | 263.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 3.1 | 64.3 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 3.0 | 98.1 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 3.0 | 50.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 3.0 | 26.6 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 2.9 | 48.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 2.8 | 14.0 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 2.6 | 85.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 2.6 | 30.8 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 2.4 | 67.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 2.4 | 57.6 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 2.4 | 44.7 | REACTOME G2 M CHECKPOINTS | Genes involved in G2/M Checkpoints |
| 2.3 | 75.0 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 2.3 | 86.2 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 2.2 | 69.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 2.2 | 120.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 2.2 | 34.6 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 2.1 | 29.2 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 2.0 | 30.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 2.0 | 62.3 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 2.0 | 19.7 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 1.9 | 29.2 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 1.9 | 13.1 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 1.8 | 40.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.8 | 23.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 1.7 | 307.0 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 1.6 | 29.3 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 1.6 | 63.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 1.6 | 20.4 | REACTOME P75NTR SIGNALS VIA NFKB | Genes involved in p75NTR signals via NF-kB |
| 1.5 | 43.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 1.4 | 24.6 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 1.4 | 17.2 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 1.4 | 167.0 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.3 | 38.7 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 1.3 | 34.2 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 1.2 | 86.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.1 | 63.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 1.1 | 11.1 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 1.0 | 36.3 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 1.0 | 7.2 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 1.0 | 6.8 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.9 | 11.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.9 | 15.8 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.9 | 18.1 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.8 | 18.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.8 | 22.6 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.8 | 26.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.8 | 27.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.8 | 22.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.8 | 16.3 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.8 | 26.9 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.7 | 4.4 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.7 | 30.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.7 | 27.9 | REACTOME CHROMOSOME MAINTENANCE | Genes involved in Chromosome Maintenance |
| 0.7 | 11.9 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.7 | 15.6 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.7 | 6.8 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.7 | 23.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.7 | 8.5 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.7 | 5.2 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.6 | 31.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.6 | 5.0 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.6 | 5.6 | REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 0.6 | 8.3 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.6 | 35.0 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.5 | 9.3 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 0.5 | 14.7 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.5 | 14.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.5 | 7.6 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.5 | 2.6 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.5 | 6.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.5 | 10.1 | REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 0.4 | 13.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.4 | 17.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.4 | 9.9 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.4 | 10.6 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.4 | 7.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.4 | 14.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.4 | 6.7 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.4 | 3.2 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.3 | 5.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.3 | 13.6 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.3 | 11.4 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.3 | 3.8 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.3 | 6.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 33.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 9.0 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.3 | 5.7 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.3 | 5.2 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.2 | 5.0 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.2 | 6.6 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.2 | 7.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.2 | 6.9 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.2 | 35.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 2.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 2.8 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.2 | 1.5 | REACTOME SIGNALING BY WNT | Genes involved in Signaling by Wnt |
| 0.2 | 2.1 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 1.0 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.1 | 3.1 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 2.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 2.8 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.1 | 4.7 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 2.6 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 3.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 3.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 1.9 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.5 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 14.7 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.1 | 1.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.4 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.6 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.1 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.0 | 0.8 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 4.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.8 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.2 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |