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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for E2F3
Z-value: 2.88
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Transcription factors associated with E2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F3 | hg38_v1_chr6_+_20403679_20403735, hg38_v1_chr6_+_20401864_20401921 | 0.67 | 2.5e-29 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 425.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.9 | 280.9 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 2.7 | 235.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 2.5 | 170.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 14.0 | 153.9 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 1.6 | 136.1 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 3.2 | 134.2 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 4.5 | 131.6 | GO:0006465 | signal peptide processing(GO:0006465) |
| 1.8 | 116.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 2.4 | 114.3 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.6 | 352.3 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 3.0 | 307.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 5.8 | 299.0 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.2 | 248.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.5 | 205.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 3.1 | 196.9 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 17.4 | 156.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.9 | 155.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 19.2 | 153.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.4 | 142.3 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 630.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.8 | 202.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 6.0 | 168.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.9 | 156.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 19.2 | 153.9 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.3 | 112.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.5 | 107.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 13.1 | 91.4 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 3.0 | 90.0 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 87.0 | GO:0003723 | RNA binding(GO:0003723) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 346.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.1 | 135.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.2 | 108.5 | PID E2F PATHWAY | E2F transcription factor network |
| 2.6 | 102.8 | PID ATM PATHWAY | ATM pathway |
| 7.1 | 99.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 3.4 | 99.0 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 2.0 | 81.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 3.5 | 81.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 1.9 | 73.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 1.0 | 72.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 307.0 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 4.1 | 297.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 3.1 | 263.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 4.2 | 237.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 4.9 | 187.8 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 1.4 | 167.0 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 3.4 | 154.7 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 4.5 | 154.2 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 7.6 | 144.8 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 3.8 | 120.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |