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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for E2F6
Z-value: 1.26
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Transcription factors associated with E2F6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F6 | hg38_v1_chr2_-_11466156_11466177 | 0.16 | 1.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 54.2 | GO:0030421 | defecation(GO:0030421) |
| 9.7 | 38.8 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 2.9 | 32.4 | GO:0021740 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 2.4 | 28.6 | GO:0009414 | response to water deprivation(GO:0009414) |
| 1.1 | 26.4 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 1.8 | 24.8 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 2.0 | 20.2 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.3 | 20.2 | GO:1901016 | regulation of potassium ion transmembrane transporter activity(GO:1901016) |
| 4.9 | 19.4 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 3.8 | 18.8 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 43.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 2.2 | 37.4 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 36.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 35.9 | GO:0032432 | actin filament bundle(GO:0032432) |
| 1.5 | 31.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.8 | 30.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 2.7 | 27.0 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 1.9 | 25.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 3.1 | 24.7 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 22.5 | GO:0005925 | focal adhesion(GO:0005925) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 77.6 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.5 | 73.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 69.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 9.7 | 38.8 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 3.0 | 38.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.4 | 34.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 25.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.2 | 23.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.8 | 22.2 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.2 | 20.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 105.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 1.3 | 63.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.7 | 52.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.2 | 47.9 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.2 | 42.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 40.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 32.0 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.3 | 26.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 22.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 22.3 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 85.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 67.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.7 | 44.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 1.1 | 38.0 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.3 | 32.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.8 | 27.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.5 | 24.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.1 | 23.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.7 | 22.4 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.6 | 20.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |