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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for E2F7_E2F1
Z-value: 4.51
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F1 | hg38_v1_chr20_-_33686371_33686407 | 0.74 | 1.0e-39 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 28.5 | 626.2 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 45.2 | 587.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 11.6 | 473.6 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 76.8 | 307.0 | GO:0019860 | uracil metabolic process(GO:0019860) |
| 3.4 | 300.4 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 23.0 | 298.9 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 10.9 | 283.1 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 6.1 | 258.2 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 85.5 | 256.5 | GO:0006311 | meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520) |
| 3.3 | 249.2 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 57.9 | 753.1 | GO:0042555 | MCM complex(GO:0042555) |
| 135.1 | 540.5 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 64.5 | 322.5 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 3.4 | 311.5 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 26.5 | 291.9 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 18.1 | 289.6 | GO:0045120 | pronucleus(GO:0045120) |
| 35.3 | 282.7 | GO:0000796 | condensin complex(GO:0000796) |
| 16.4 | 279.1 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.7 | 244.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 2.2 | 230.1 | GO:0031970 | organelle envelope lumen(GO:0031970) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.3 | 693.6 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 135.1 | 540.5 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 38.5 | 500.9 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 2.4 | 389.1 | GO:0042393 | histone binding(GO:0042393) |
| 64.5 | 322.5 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 22.4 | 313.3 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 1.5 | 306.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 8.7 | 260.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 5.4 | 254.8 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.7 | 249.8 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.6 | 1859.2 | PID E2F PATHWAY | E2F transcription factor network |
| 10.2 | 568.6 | PID ATR PATHWAY | ATR signaling pathway |
| 2.4 | 460.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 15.3 | 306.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 2.3 | 237.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 4.0 | 230.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.1 | 191.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 4.8 | 190.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 5.4 | 189.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 1.6 | 172.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.5 | 974.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 59.4 | 890.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 5.6 | 860.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.3 | 498.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 4.6 | 445.3 | REACTOME S PHASE | Genes involved in S Phase |
| 29.3 | 381.1 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 2.4 | 367.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 21.9 | 328.5 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 8.9 | 293.8 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 8.5 | 253.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |