Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for E2F8
Z-value: 1.80
Motif logo
Transcription factors associated with E2F8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F8 | hg38_v1_chr11_-_19241598_19241628, hg38_v1_chr11_-_19240936_19240968 | 0.57 | 1.6e-20 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_10123171 Show fit | 72.11 |
ENST00000615152.5
|
ribonucleotide reductase regulatory subunit M2 |
|
| chr2_+_10122730 Show fit | 64.69 |
ENST00000304567.10
|
ribonucleotide reductase regulatory subunit M2 |
|
| chr4_-_173333672 Show fit | 56.55 |
ENST00000438704.6
|
high mobility group box 2 |
|
| chr2_-_135876382 Show fit | 51.46 |
ENST00000264156.3
|
minichromosome maintenance complex component 6 |
|
| chr6_+_135181268 Show fit | 47.17 |
ENST00000341911.10
ENST00000442647.7 ENST00000618728.4 ENST00000316528.12 ENST00000616088.4 |
MYB proto-oncogene, transcription factor |
|
| chr6_+_135181323 Show fit | 46.09 |
ENST00000367814.8
|
MYB proto-oncogene, transcription factor |
|
| chr20_+_43667105 Show fit | 38.98 |
ENST00000217026.5
|
MYB proto-oncogene like 2 |
|
| chr8_+_127736046 Show fit | 35.11 |
ENST00000641036.1
ENST00000377970.6 |
MYC proto-oncogene, bHLH transcription factor |
|
| chr1_-_159923717 Show fit | 35.08 |
ENST00000368096.5
|
transgelin 2 |
|
| chr3_+_127598400 Show fit | 34.55 |
ENST00000265056.12
|
minichromosome maintenance complex component 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 136.8 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 8.1 | 105.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 34.5 | 103.4 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 7.0 | 84.5 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.9 | 78.8 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 17.1 | 68.3 | GO:0090094 | metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 1.0 | 60.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 9.8 | 59.0 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 14.4 | 57.7 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.7 | 57.4 | GO:0043525 | positive regulation of neuron apoptotic process(GO:0043525) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.0 | 143.1 | GO:0042555 | MCM complex(GO:0042555) |
| 34.2 | 136.8 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.4 | 98.3 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.3 | 87.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 7.1 | 77.6 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 73.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.5 | 72.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.9 | 63.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 11.5 | 57.7 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 11.5 | 57.4 | GO:0031523 | Myb complex(GO:0031523) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 160.8 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 34.2 | 136.8 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 21.1 | 84.5 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 4.9 | 82.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 19.4 | 77.6 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) |
| 1.5 | 70.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 1.0 | 70.3 | GO:0070888 | E-box binding(GO:0070888) |
| 1.8 | 68.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.1 | 60.6 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 19.2 | 57.7 | GO:0003896 | DNA primase activity(GO:0003896) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 249.5 | PID E2F PATHWAY | E2F transcription factor network |
| 2.6 | 176.8 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 2.1 | 84.6 | PID BARD1 PATHWAY | BARD1 signaling events |
| 1.1 | 54.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.9 | 45.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.9 | 41.5 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 40.4 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.5 | 34.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 2.5 | 34.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 30.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.1 | 167.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 4.7 | 142.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.7 | 120.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 5.6 | 84.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.9 | 78.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 5.2 | 77.6 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.6 | 76.0 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.6 | 68.3 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 5.2 | 67.0 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.3 | 60.9 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |