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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for E4F1
Z-value: 0.65
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Transcription factors associated with E4F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E4F1 | hg38_v1_chr16_+_2223555_2223636 | 0.35 | 1.4e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E4F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.7 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.8 | 14.4 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 3.5 | 13.9 | GO:2000173 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 2.0 | 12.1 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.0 | 8.9 | GO:0030323 | respiratory tube development(GO:0030323) |
| 0.4 | 7.8 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 1.8 | 7.4 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.1 | 6.6 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.3 | 5.5 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 1.1 | 5.3 | GO:0051415 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 19.7 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 15.0 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 14.2 | GO:0044297 | cell body(GO:0044297) |
| 0.1 | 9.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 8.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 6.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.3 | 5.3 | GO:0008275 | gamma-tubulin small complex(GO:0008275) |
| 0.1 | 4.9 | GO:0071437 | invadopodium(GO:0071437) |
| 0.1 | 4.4 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.6 | 4.3 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 13.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 12.4 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.4 | 12.1 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.0 | 9.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 7.8 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 7.5 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 1.1 | 7.4 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.5 | 5.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.8 | 4.9 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 12.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 9.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 9.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 7.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.2 | 6.4 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.1 | 4.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 4.3 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 3.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 2.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.5 | PID IL12 2PATHWAY | IL12-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.5 | 12.1 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.1 | 9.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 7.9 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.1 | 5.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.5 | 5.3 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.2 | 4.9 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.2 | 4.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 4.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |