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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EBF3
Z-value: 0.89
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Transcription factors associated with EBF3
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153544997 Show fit | 12.63 |
ENST00000368715.5
|
S100 calcium binding protein A4 |
|
| chr8_+_22578735 Show fit | 9.68 |
ENST00000339162.11
ENST00000308354.11 |
PDZ and LIM domain 2 |
|
| chr19_-_2042066 Show fit | 8.70 |
ENST00000591588.1
ENST00000591142.5 |
MAPK interacting serine/threonine kinase 2 |
|
| chr8_+_22579100 Show fit | 8.36 |
ENST00000452226.5
ENST00000397760.8 |
PDZ and LIM domain 2 |
|
| chr16_+_32066065 Show fit | 8.08 |
ENST00000354689.6
|
immunoglobulin heavy variable 3/OR16-9 (non-functional) |
|
| chr7_-_101237760 Show fit | 7.82 |
ENST00000412417.1
ENST00000414035.5 |
claudin 15 |
|
| chr8_+_22579139 Show fit | 7.50 |
ENST00000397761.6
|
PDZ and LIM domain 2 |
|
| chr19_-_45322867 Show fit | 7.31 |
ENST00000221476.4
|
creatine kinase, M-type |
|
| chr1_-_112704921 Show fit | 7.21 |
ENST00000414971.1
ENST00000534717.5 |
ras homolog family member C |
|
| chr1_-_153550083 Show fit | 6.94 |
ENST00000368714.1
|
S100 calcium binding protein A4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 45.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.4 | 38.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 23.6 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.1 | 17.0 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.1 | 16.1 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 14.1 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.4 | 14.0 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.9 | 13.7 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 1.5 | 11.8 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 1.0 | 10.7 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 41.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 20.1 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 15.8 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.2 | 15.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.6 | 12.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 11.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 11.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.2 | 11.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 2.6 | 10.6 | GO:0071749 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 0.1 | 9.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 45.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 36.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.8 | 22.9 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 1.0 | 19.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.2 | 13.8 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.1 | 12.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 12.1 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.7 | 12.0 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 1.8 | 10.5 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.5 | 9.4 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.0 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 18.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 18.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 15.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 14.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 10.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 10.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 9.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 8.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 7.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 26.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 14.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 9.4 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 9.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 8.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 7.3 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.3 | 6.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 6.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 6.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |