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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EGR1_EGR4
Z-value: 1.15
Motif logo
Transcription factors associated with EGR1_EGR4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
EGR1
|
ENSG00000120738.8 | EGR1 |
|
EGR4
|
ENSG00000135625.8 | EGR4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR4 | hg38_v1_chr2_-_73293538_73293701 | 0.37 | 2.8e-08 | Click! |
| EGR1 | hg38_v1_chr5_+_138465472_138465487 | 0.28 | 2.3e-05 | Click! |
Activity profile of EGR1_EGR4 motif
Sorted Z-values of EGR1_EGR4 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR1_EGR4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 40.5 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 6.4 | 19.3 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 5.4 | 16.1 | GO:1902595 | regulation of DNA replication origin binding(GO:1902595) |
| 5.3 | 15.9 | GO:0048319 | axial mesoderm morphogenesis(GO:0048319) |
| 4.6 | 27.9 | GO:0016926 | protein desumoylation(GO:0016926) |
| 4.6 | 13.8 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 4.0 | 12.1 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
| 3.9 | 15.7 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 3.3 | 9.9 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 3.3 | 13.1 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021) |
| 3.2 | 9.7 | GO:0034148 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) |
| 3.1 | 12.5 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 3.1 | 9.3 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 3.0 | 9.0 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 3.0 | 9.0 | GO:0006864 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 2.9 | 8.8 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 2.9 | 8.6 | GO:0099557 | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission(GO:0099557) |
| 2.7 | 10.9 | GO:0072237 | metanephric proximal tubule development(GO:0072237) |
| 2.7 | 10.8 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
| 2.5 | 7.4 | GO:0072716 | response to actinomycin D(GO:0072716) |
| 2.5 | 41.8 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 2.4 | 2.4 | GO:1904674 | positive regulation of somatic stem cell population maintenance(GO:1904674) |
| 2.4 | 9.6 | GO:1901339 | regulation of store-operated calcium channel activity(GO:1901339) |
| 2.3 | 2.3 | GO:1902303 | negative regulation of potassium ion export(GO:1902303) |
| 2.2 | 9.0 | GO:1903116 | positive regulation of actin filament-based movement(GO:1903116) positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
| 2.2 | 6.6 | GO:0008355 | olfactory learning(GO:0008355) |
| 2.2 | 44.0 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 2.2 | 17.3 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 2.1 | 8.4 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 2.0 | 8.2 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
| 2.0 | 2.0 | GO:0034146 | toll-like receptor 5 signaling pathway(GO:0034146) |
| 2.0 | 9.9 | GO:1901907 | diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 1.9 | 5.8 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 1.9 | 7.7 | GO:0006258 | UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879) negative regulation of type B pancreatic cell development(GO:2000077) |
| 1.9 | 5.7 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582) |
| 1.8 | 8.8 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 1.7 | 6.8 | GO:0014859 | negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) |
| 1.7 | 6.8 | GO:0002357 | defense response to tumor cell(GO:0002357) |
| 1.7 | 6.7 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 1.7 | 6.7 | GO:0052552 | induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) |
| 1.7 | 8.3 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 1.6 | 9.8 | GO:0061092 | involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 1.6 | 4.8 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 1.6 | 8.0 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 1.6 | 4.7 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 1.6 | 6.3 | GO:0051697 | protein delipidation(GO:0051697) |
| 1.5 | 6.0 | GO:2000327 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 1.5 | 6.0 | GO:1902617 | response to fluoride(GO:1902617) |
| 1.5 | 10.4 | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 1.5 | 5.9 | GO:0031161 | phosphatidylinositol catabolic process(GO:0031161) |
| 1.4 | 2.9 | GO:0090219 | negative regulation of lipid kinase activity(GO:0090219) |
| 1.4 | 8.5 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 1.4 | 4.2 | GO:2000969 | positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969) |
| 1.4 | 4.2 | GO:0021718 | pons maturation(GO:0021586) superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 1.4 | 2.8 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 1.4 | 4.2 | GO:0045643 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 1.4 | 16.6 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 1.4 | 6.8 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 1.3 | 13.4 | GO:1902525 | regulation of protein monoubiquitination(GO:1902525) |
| 1.3 | 1.3 | GO:1901979 | regulation of inward rectifier potassium channel activity(GO:1901979) |
| 1.3 | 15.7 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 1.3 | 3.9 | GO:0060903 | positive regulation of meiosis I(GO:0060903) |
| 1.3 | 3.8 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 1.2 | 15.9 | GO:0043320 | natural killer cell degranulation(GO:0043320) |
| 1.2 | 3.6 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 1.2 | 4.8 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 1.2 | 7.2 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.2 | 7.0 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 1.2 | 9.2 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 1.2 | 3.5 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 1.1 | 6.9 | GO:0061152 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 1.1 | 3.4 | GO:0048073 | regulation of eye pigmentation(GO:0048073) |
| 1.1 | 10.1 | GO:0042670 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 1.1 | 6.7 | GO:0051585 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 1.1 | 3.3 | GO:0098528 | skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809) |
| 1.1 | 4.4 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 1.1 | 18.4 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 1.1 | 4.3 | GO:0060734 | regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 1.0 | 3.1 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 1.0 | 8.0 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 1.0 | 13.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 1.0 | 3.0 | GO:0003358 | noradrenergic neuron development(GO:0003358) |
| 1.0 | 4.9 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 1.0 | 2.9 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 1.0 | 7.8 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 1.0 | 14.6 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 1.0 | 4.8 | GO:0030070 | insulin processing(GO:0030070) |
| 1.0 | 8.6 | GO:0033578 | protein glycosylation in Golgi(GO:0033578) |
| 1.0 | 5.7 | GO:0090116 | C-5 methylation of cytosine(GO:0090116) |
| 0.9 | 3.8 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.9 | 15.0 | GO:0032025 | response to cobalt ion(GO:0032025) |
| 0.9 | 3.7 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.9 | 4.7 | GO:0030311 | poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.9 | 2.8 | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation(GO:1905064) |
| 0.9 | 14.5 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
| 0.9 | 8.1 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.9 | 2.7 | GO:1904616 | regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616) |
| 0.9 | 9.0 | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.9 | 3.6 | GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 0.9 | 4.4 | GO:0072366 | regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366) |
| 0.9 | 3.5 | GO:1904924 | negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924) |
| 0.9 | 2.6 | GO:0090187 | positive regulation of pancreatic juice secretion(GO:0090187) |
| 0.9 | 4.3 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.9 | 4.3 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.8 | 3.4 | GO:0072103 | glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104) |
| 0.8 | 2.5 | GO:0032776 | DNA methylation on cytosine(GO:0032776) |
| 0.8 | 3.3 | GO:1990834 | negative regulation of T-helper 1 cell differentiation(GO:0045626) response to odorant(GO:1990834) |
| 0.8 | 1.6 | GO:0015959 | diadenosine polyphosphate metabolic process(GO:0015959) |
| 0.8 | 2.4 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 0.8 | 2.4 | GO:1900239 | phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239) |
| 0.8 | 9.8 | GO:0060019 | radial glial cell differentiation(GO:0060019) |
| 0.8 | 4.8 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.8 | 6.4 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.8 | 6.4 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.8 | 3.2 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.8 | 8.7 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.8 | 10.9 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.8 | 0.8 | GO:0090598 | male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598) |
| 0.8 | 10.8 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.8 | 3.1 | GO:0050916 | sensory perception of sweet taste(GO:0050916) |
| 0.8 | 4.5 | GO:0034128 | negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) |
| 0.7 | 12.6 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.7 | 6.6 | GO:0007135 | meiosis II(GO:0007135) |
| 0.7 | 7.3 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.7 | 2.2 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.7 | 2.1 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 0.7 | 1.4 | GO:0043974 | histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674) |
| 0.7 | 1.3 | GO:0070346 | positive regulation of fat cell proliferation(GO:0070346) |
| 0.7 | 13.9 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.7 | 1.3 | GO:0002537 | nitric oxide production involved in inflammatory response(GO:0002537) |
| 0.7 | 5.9 | GO:0097688 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.6 | 5.8 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.6 | 5.8 | GO:0035865 | cellular response to potassium ion(GO:0035865) |
| 0.6 | 1.9 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.6 | 2.6 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.6 | 7.0 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.6 | 56.1 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.6 | 11.4 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 0.6 | 1.9 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 0.6 | 5.0 | GO:0021873 | forebrain neuroblast division(GO:0021873) |
| 0.6 | 3.1 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
| 0.6 | 1.9 | GO:0006172 | ADP biosynthetic process(GO:0006172) purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183) |
| 0.6 | 3.1 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
| 0.6 | 4.8 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.6 | 1.8 | GO:0001757 | somite specification(GO:0001757) |
| 0.6 | 8.5 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.6 | 0.6 | GO:0061056 | sclerotome development(GO:0061056) |
| 0.6 | 6.6 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.6 | 4.8 | GO:0034625 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.6 | 4.7 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.6 | 4.6 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.6 | 3.4 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.6 | 4.6 | GO:0061368 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.6 | 6.8 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.6 | 2.3 | GO:0071110 | protein biotinylation(GO:0009305) histone biotinylation(GO:0071110) |
| 0.6 | 1.1 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.6 | 8.4 | GO:0010918 | positive regulation of mitochondrial membrane potential(GO:0010918) |
| 0.5 | 3.3 | GO:0033152 | immunoglobulin V(D)J recombination(GO:0033152) |
| 0.5 | 1.6 | GO:0098935 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 0.5 | 5.4 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.5 | 1.6 | GO:2001033 | oncogene-induced cell senescence(GO:0090402) negative regulation of double-strand break repair via nonhomologous end joining(GO:2001033) |
| 0.5 | 1.6 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.5 | 2.1 | GO:0044026 | DNA hypermethylation(GO:0044026) |
| 0.5 | 4.7 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.5 | 5.2 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.5 | 1.0 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.5 | 1.5 | GO:1900425 | negative regulation of defense response to bacterium(GO:1900425) |
| 0.5 | 4.6 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.5 | 7.2 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.5 | 2.6 | GO:0090118 | receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) |
| 0.5 | 6.6 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.5 | 2.0 | GO:0010868 | negative regulation of triglyceride biosynthetic process(GO:0010868) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.5 | 11.0 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.5 | 3.4 | GO:0010694 | positive regulation of alkaline phosphatase activity(GO:0010694) |
| 0.5 | 2.4 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.5 | 1.5 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.5 | 8.7 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.5 | 1.9 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.5 | 2.9 | GO:0050893 | sensory processing(GO:0050893) |
| 0.5 | 1.4 | GO:0032223 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.5 | 1.4 | GO:0042412 | taurine biosynthetic process(GO:0042412) |
| 0.4 | 2.6 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.4 | 1.3 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.4 | 1.3 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) |
| 0.4 | 1.7 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.4 | 1.3 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
| 0.4 | 0.8 | GO:0060061 | Spemann organizer formation(GO:0060061) |
| 0.4 | 2.1 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.4 | 4.2 | GO:2000318 | positive regulation of T-helper 17 type immune response(GO:2000318) |
| 0.4 | 11.3 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.4 | 1.2 | GO:0060684 | epithelial-mesenchymal cell signaling(GO:0060684) |
| 0.4 | 17.9 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.4 | 3.6 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.4 | 4.0 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.4 | 2.4 | GO:0042636 | negative regulation of hair cycle(GO:0042636) |
| 0.4 | 14.4 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.4 | 4.8 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 0.4 | 0.8 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.4 | 18.8 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.4 | 7.7 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.4 | 1.2 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.4 | 2.7 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 0.4 | 1.9 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.4 | 6.4 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.4 | 4.8 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.4 | 2.6 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.4 | 2.2 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.4 | 4.0 | GO:0021694 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.4 | 3.7 | GO:0045945 | positive regulation of transcription from RNA polymerase III promoter(GO:0045945) |
| 0.4 | 6.5 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.4 | 2.5 | GO:1905232 | cellular response to L-glutamate(GO:1905232) |
| 0.4 | 3.9 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.4 | 1.8 | GO:0030538 | embryonic genitalia morphogenesis(GO:0030538) |
| 0.4 | 1.1 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.4 | 2.1 | GO:0097029 | mature conventional dendritic cell differentiation(GO:0097029) |
| 0.4 | 4.6 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.3 | 1.7 | GO:0038163 | thrombopoietin-mediated signaling pathway(GO:0038163) |
| 0.3 | 2.1 | GO:0034141 | positive regulation of toll-like receptor 3 signaling pathway(GO:0034141) |
| 0.3 | 8.6 | GO:0060008 | Sertoli cell differentiation(GO:0060008) |
| 0.3 | 7.7 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.3 | 1.3 | GO:0035900 | response to isolation stress(GO:0035900) |
| 0.3 | 2.3 | GO:1902949 | positive regulation of tau-protein kinase activity(GO:1902949) |
| 0.3 | 2.3 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.3 | 3.3 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.3 | 2.3 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.3 | 2.9 | GO:0070444 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.3 | 2.2 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.3 | 3.7 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571) |
| 0.3 | 2.1 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.3 | 3.1 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.3 | 1.2 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 0.3 | 1.2 | GO:0003431 | growth plate cartilage chondrocyte growth(GO:0003430) growth plate cartilage chondrocyte development(GO:0003431) trachea cartilage development(GO:0060534) Harderian gland development(GO:0070384) |
| 0.3 | 4.5 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
| 0.3 | 1.2 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
| 0.3 | 1.2 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.3 | 2.4 | GO:0060766 | negative regulation of androgen receptor signaling pathway(GO:0060766) |
| 0.3 | 1.2 | GO:1903182 | regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755) |
| 0.3 | 8.8 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.3 | 1.4 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.3 | 8.3 | GO:0090312 | positive regulation of protein deacetylation(GO:0090312) |
| 0.3 | 4.2 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.3 | 1.4 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.3 | 7.2 | GO:0009299 | mRNA transcription(GO:0009299) |
| 0.3 | 4.6 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.3 | 2.4 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.3 | 7.8 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.3 | 1.3 | GO:1905245 | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 0.3 | 2.1 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
| 0.3 | 1.8 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.3 | 2.1 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.3 | 4.6 | GO:0014898 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.3 | 6.5 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.3 | 3.3 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.2 | 1.5 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.2 | 1.5 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.2 | 1.0 | GO:0072301 | metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) regulation of metanephric glomerular mesangial cell proliferation(GO:0072301) |
| 0.2 | 1.9 | GO:0035524 | proline transmembrane transport(GO:0035524) |
| 0.2 | 4.6 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.2 | 3.2 | GO:0044126 | regulation of growth of symbiont in host(GO:0044126) |
| 0.2 | 0.7 | GO:0061011 | gall bladder development(GO:0061010) hepatic duct development(GO:0061011) |
| 0.2 | 7.1 | GO:0010719 | negative regulation of epithelial to mesenchymal transition(GO:0010719) |
| 0.2 | 2.1 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.2 | 2.1 | GO:0015871 | choline transport(GO:0015871) |
| 0.2 | 1.9 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.2 | 2.3 | GO:0010764 | negative regulation of fibroblast migration(GO:0010764) |
| 0.2 | 1.9 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.2 | 2.8 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.2 | 1.2 | GO:0001992 | regulation of systemic arterial blood pressure by vasopressin(GO:0001992) |
| 0.2 | 4.6 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.2 | 5.7 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.2 | 2.5 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.2 | 1.8 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.2 | 2.7 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
| 0.2 | 0.9 | GO:0015870 | acetylcholine transport(GO:0015870) |
| 0.2 | 4.8 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.2 | 0.7 | GO:1901874 | negative regulation of post-translational protein modification(GO:1901874) |
| 0.2 | 4.7 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.2 | 1.9 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.2 | 1.3 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 0.6 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.2 | 1.4 | GO:0032960 | regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.2 | 1.6 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.2 | 1.2 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.2 | 1.6 | GO:2000574 | regulation of microtubule motor activity(GO:2000574) |
| 0.2 | 1.2 | GO:0007549 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.2 | 3.6 | GO:0022011 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.2 | 2.0 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.2 | 0.8 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.2 | 0.6 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 0.2 | 12.4 | GO:0071364 | cellular response to epidermal growth factor stimulus(GO:0071364) |
| 0.2 | 3.5 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.2 | 1.5 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.2 | 2.8 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.2 | 1.5 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.2 | 2.2 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 0.2 | 2.8 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.2 | 2.0 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.2 | 1.6 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.2 | 0.9 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
| 0.2 | 2.2 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.2 | 3.6 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.2 | 1.6 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.2 | 3.5 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.2 | 1.0 | GO:0060482 | bronchus development(GO:0060433) lobar bronchus epithelium development(GO:0060481) lobar bronchus development(GO:0060482) |
| 0.2 | 1.5 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.2 | 4.0 | GO:0043949 | regulation of cAMP-mediated signaling(GO:0043949) |
| 0.2 | 0.8 | GO:0009450 | gamma-aminobutyric acid catabolic process(GO:0009450) |
| 0.2 | 0.7 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.2 | 1.8 | GO:0097106 | postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107) gephyrin clustering involved in postsynaptic density assembly(GO:0097116) neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.2 | 1.1 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 0.2 | 1.3 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.2 | 1.1 | GO:0051024 | positive regulation of immunoglobulin secretion(GO:0051024) |
| 0.2 | 7.6 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.2 | 2.0 | GO:0045879 | negative regulation of smoothened signaling pathway(GO:0045879) |
| 0.2 | 2.8 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.2 | 10.7 | GO:0008306 | associative learning(GO:0008306) |
| 0.2 | 1.7 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.2 | 1.6 | GO:0060068 | vagina development(GO:0060068) |
| 0.2 | 5.4 | GO:0090022 | regulation of neutrophil chemotaxis(GO:0090022) |
| 0.2 | 2.9 | GO:0021904 | dorsal/ventral neural tube patterning(GO:0021904) |
| 0.1 | 1.5 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
| 0.1 | 2.3 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 1.6 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.1 | 0.9 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.1 | 0.4 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.1 | 0.7 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.1 | 2.2 | GO:0030828 | positive regulation of cGMP biosynthetic process(GO:0030828) |
| 0.1 | 3.1 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 3.3 | GO:0030033 | microvillus assembly(GO:0030033) |
| 0.1 | 3.0 | GO:0097503 | sialylation(GO:0097503) |
| 0.1 | 3.7 | GO:0001510 | RNA methylation(GO:0001510) |
| 0.1 | 5.0 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.1 | 0.7 | GO:0014050 | negative regulation of glutamate secretion(GO:0014050) |
| 0.1 | 1.3 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.1 | 2.8 | GO:0035640 | exploration behavior(GO:0035640) |
| 0.1 | 1.4 | GO:0007625 | grooming behavior(GO:0007625) |
| 0.1 | 2.5 | GO:0006972 | hyperosmotic response(GO:0006972) |
| 0.1 | 0.5 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.1 | 2.8 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 7.8 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.1 | 2.8 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.1 | 0.9 | GO:1904293 | negative regulation of ERAD pathway(GO:1904293) |
| 0.1 | 4.5 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.1 | 3.4 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.1 | 1.2 | GO:0032494 | response to peptidoglycan(GO:0032494) |
| 0.1 | 2.3 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.1 | 2.8 | GO:0043243 | positive regulation of protein complex disassembly(GO:0043243) |
| 0.1 | 1.7 | GO:0051194 | positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) |
| 0.1 | 0.3 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.1 | 1.2 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 2.2 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
| 0.1 | 2.0 | GO:0003091 | renal water homeostasis(GO:0003091) |
| 0.1 | 1.7 | GO:0039694 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.1 | 5.2 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 5.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 0.5 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.1 | 11.1 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.1 | 0.7 | GO:0043586 | tongue development(GO:0043586) |
| 0.1 | 0.5 | GO:0055057 | neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057) |
| 0.1 | 0.8 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.1 | 1.1 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.1 | 1.8 | GO:0018023 | peptidyl-lysine trimethylation(GO:0018023) |
| 0.1 | 1.1 | GO:0099515 | vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515) |
| 0.1 | 1.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 1.0 | GO:0048485 | sympathetic nervous system development(GO:0048485) |
| 0.1 | 0.7 | GO:0035278 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.1 | 0.5 | GO:0048840 | otolith development(GO:0048840) |
| 0.1 | 0.4 | GO:0071386 | cellular response to corticosterone stimulus(GO:0071386) |
| 0.1 | 5.5 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.1 | 1.5 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.1 | 1.5 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 1.3 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 0.5 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.1 | 1.1 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 2.1 | GO:0050691 | regulation of defense response to virus by host(GO:0050691) |
| 0.1 | 4.9 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.1 | 0.6 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.1 | 1.0 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.1 | 1.6 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 1.6 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.1 | 1.9 | GO:0071218 | cellular response to misfolded protein(GO:0071218) |
| 0.1 | 3.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.3 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.1 | 3.1 | GO:0006306 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.1 | 18.1 | GO:0007601 | visual perception(GO:0007601) |
| 0.1 | 0.9 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.1 | 8.3 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 0.6 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.1 | 1.2 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.1 | 1.7 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.1 | 3.1 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.1 | 3.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 0.6 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 0.1 | 2.9 | GO:0050909 | sensory perception of taste(GO:0050909) |
| 0.1 | 0.4 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 0.4 | GO:0072502 | cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.1 | 1.3 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.1 | 2.2 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 0.1 | 1.6 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.1 | 2.3 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.1 | 3.8 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.1 | 0.9 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 0.1 | 0.5 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.1 | 4.8 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.1 | 0.7 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.1 | 1.1 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 0.5 | GO:0009052 | pentose-phosphate shunt, non-oxidative branch(GO:0009052) |
| 0.1 | 0.2 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.1 | 2.1 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.1 | 1.6 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.1 | 1.5 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.1 | 9.9 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.1 | 1.0 | GO:0009880 | embryonic pattern specification(GO:0009880) |
| 0.1 | 1.4 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 1.6 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 5.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.5 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.8 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 4.3 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.5 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.3 | GO:0045176 | apical protein localization(GO:0045176) |
| 0.0 | 1.1 | GO:1903861 | regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 0.5 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.0 | 0.2 | GO:1902857 | nonmotile primary cilium assembly(GO:0035058) regulation of nonmotile primary cilium assembly(GO:1902855) positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 2.3 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.0 | 2.5 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.0 | 1.8 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.5 | GO:0040020 | regulation of meiotic nuclear division(GO:0040020) |
| 0.0 | 1.2 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 1.5 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.0 | 0.8 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 2.0 | GO:0070671 | interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349) |
| 0.0 | 2.9 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.9 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.0 | 1.0 | GO:0000045 | autophagosome assembly(GO:0000045) |
| 0.0 | 0.5 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 1.3 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 2.7 | GO:0050709 | negative regulation of protein secretion(GO:0050709) |
| 0.0 | 0.4 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 1.7 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 1.8 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.1 | GO:1902659 | regulation of glucose mediated signaling pathway(GO:1902659) |
| 0.0 | 3.4 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.0 | 0.3 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.0 | 2.2 | GO:0071805 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 1.8 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
| 0.0 | 0.2 | GO:0015732 | prostaglandin transport(GO:0015732) |
| 0.0 | 0.0 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.0 | 2.2 | GO:0007586 | digestion(GO:0007586) |
| 0.0 | 0.1 | GO:0032228 | regulation of synaptic transmission, GABAergic(GO:0032228) synaptic transmission, GABAergic(GO:0051932) |
| 0.0 | 0.6 | GO:0048278 | vesicle docking(GO:0048278) |
| 0.0 | 1.0 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.2 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 0.9 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.2 | GO:0043293 | apoptosome(GO:0043293) |
| 3.4 | 13.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 2.8 | 8.3 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 2.3 | 9.3 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 2.2 | 10.8 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 1.8 | 9.0 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 1.7 | 11.7 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 1.3 | 3.9 | GO:0000805 | X chromosome(GO:0000805) |
| 1.3 | 15.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 1.3 | 6.4 | GO:1990031 | pinceau fiber(GO:1990031) |
| 1.1 | 10.1 | GO:0044327 | dendritic spine head(GO:0044327) |
| 1.1 | 8.9 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 1.1 | 6.5 | GO:0045298 | tubulin complex(GO:0045298) |
| 1.1 | 4.3 | GO:0070695 | FHF complex(GO:0070695) |
| 1.0 | 5.2 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 1.0 | 5.1 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 1.0 | 3.9 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.9 | 20.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.9 | 17.4 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.9 | 13.5 | GO:0097433 | dense body(GO:0097433) |
| 0.9 | 1.7 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.8 | 3.4 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.8 | 4.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.8 | 6.7 | GO:0097425 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.8 | 1.7 | GO:0044308 | axonal spine(GO:0044308) |
| 0.8 | 12.1 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.8 | 11.0 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.8 | 3.0 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.7 | 5.0 | GO:0032021 | NELF complex(GO:0032021) |
| 0.7 | 2.7 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.7 | 13.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.6 | 38.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.6 | 3.8 | GO:0031501 | mannosyltransferase complex(GO:0031501) |
| 0.6 | 2.9 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.6 | 6.4 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.6 | 4.5 | GO:0072487 | MSL complex(GO:0072487) |
| 0.6 | 11.6 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.5 | 7.1 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.5 | 26.2 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.5 | 16.2 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.5 | 10.6 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.5 | 3.7 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.5 | 5.1 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.5 | 11.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.5 | 6.5 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.5 | 5.0 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.5 | 1.5 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.5 | 79.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.5 | 7.7 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.5 | 1.8 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.5 | 8.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.4 | 3.3 | GO:0000243 | commitment complex(GO:0000243) |
| 0.4 | 20.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.4 | 2.4 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.4 | 6.4 | GO:0005883 | neurofilament(GO:0005883) |
| 0.4 | 4.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.4 | 23.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.4 | 4.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.4 | 1.8 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.4 | 2.2 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.4 | 1.8 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.4 | 5.8 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.4 | 0.4 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.4 | 4.7 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.4 | 1.1 | GO:0070701 | mucus layer(GO:0070701) |
| 0.3 | 30.4 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.3 | 2.4 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.3 | 16.6 | GO:0016235 | aggresome(GO:0016235) |
| 0.3 | 4.4 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.3 | 49.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.3 | 25.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.3 | 9.2 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.3 | 3.9 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.3 | 11.0 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.3 | 4.1 | GO:0008091 | spectrin(GO:0008091) |
| 0.3 | 1.2 | GO:1990356 | sumoylated E2 ligase complex(GO:1990356) |
| 0.3 | 2.0 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.3 | 1.1 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.3 | 12.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.3 | 4.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.3 | 2.8 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.2 | 1.7 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.2 | 3.9 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.2 | 1.4 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 31.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.2 | 4.2 | GO:0005922 | connexon complex(GO:0005922) |
| 0.2 | 2.8 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.2 | 3.2 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.2 | 11.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 23.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.2 | 2.3 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.2 | 2.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.2 | 5.7 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.2 | 1.9 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.2 | 4.5 | GO:0031312 | extrinsic component of organelle membrane(GO:0031312) |
| 0.2 | 6.4 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.2 | 5.4 | GO:0032420 | stereocilium(GO:0032420) |
| 0.2 | 1.2 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.2 | 3.0 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.2 | 2.4 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.2 | 2.8 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.2 | 1.0 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.2 | 4.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 1.7 | GO:0001741 | XY body(GO:0001741) |
| 0.2 | 6.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 1.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.1 | 1.2 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 4.1 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 1.5 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 31.6 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 18.6 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.1 | 1.0 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
| 0.1 | 1.3 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.1 | 0.9 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 2.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 1.4 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 1.6 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 2.8 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 11.0 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 4.0 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 3.3 | GO:0070461 | SAGA-type complex(GO:0070461) |
| 0.1 | 1.9 | GO:0000780 | condensed nuclear chromosome, centromeric region(GO:0000780) |
| 0.1 | 4.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 2.8 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 1.5 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 0.9 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.1 | 0.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.9 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 1.5 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.1 | 0.6 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.1 | 1.0 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 3.1 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.1 | 10.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 1.3 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 2.3 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 2.4 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 0.2 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 6.7 | GO:0098794 | postsynapse(GO:0098794) |
| 0.1 | 1.9 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.1 | 2.4 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.6 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.0 | 17.0 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 0.9 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.6 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.9 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 4.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.1 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 0.0 | 0.2 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 1.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.4 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 5.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.8 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 2.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.7 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.5 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 1.6 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.1 | 40.5 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 4.6 | 27.9 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 4.6 | 13.8 | GO:0019959 | interleukin-8 binding(GO:0019959) |
| 4.4 | 13.1 | GO:0031687 | A2A adenosine receptor binding(GO:0031687) |
| 4.0 | 16.1 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 3.1 | 12.5 | GO:0097001 | ceramide binding(GO:0097001) |
| 3.0 | 9.0 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 2.7 | 57.6 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 2.7 | 15.9 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 2.6 | 7.9 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 2.5 | 41.8 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 2.1 | 8.4 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 2.0 | 8.2 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 2.0 | 27.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 2.0 | 9.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 2.0 | 9.9 | GO:0034431 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848) |
| 1.8 | 7.1 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 1.8 | 15.9 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 1.7 | 6.7 | GO:0005471 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 1.7 | 8.3 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 1.6 | 9.8 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 1.6 | 8.1 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 1.6 | 8.0 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 1.5 | 4.6 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 1.5 | 15.1 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 1.5 | 4.5 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 1.4 | 4.2 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 1.4 | 4.1 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 1.3 | 10.4 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 1.3 | 3.8 | GO:0004584 | dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584) |
| 1.2 | 6.1 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 1.2 | 9.6 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 1.2 | 7.2 | GO:0008142 | oxysterol binding(GO:0008142) |
| 1.2 | 11.9 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
| 1.1 | 8.0 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 1.1 | 18.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 1.1 | 6.7 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 1.1 | 5.5 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 1.1 | 53.6 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 1.1 | 5.3 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 1.0 | 4.2 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 1.0 | 8.0 | GO:0016433 | rRNA (adenine) methyltransferase activity(GO:0016433) |
| 1.0 | 2.9 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 1.0 | 5.7 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.9 | 3.8 | GO:0034353 | RNA pyrophosphohydrolase activity(GO:0034353) |
| 0.9 | 14.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.9 | 4.7 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.9 | 5.4 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.9 | 7.1 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.9 | 0.9 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.9 | 4.3 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.9 | 19.7 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.8 | 3.3 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.8 | 2.5 | GO:0030290 | sphingolipid activator protein activity(GO:0030290) beta-N-acetylgalactosaminidase activity(GO:0032428) |
| 0.8 | 9.0 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.8 | 6.5 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.8 | 6.5 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.8 | 4.0 | GO:0031762 | alpha-1A adrenergic receptor binding(GO:0031691) follicle-stimulating hormone receptor binding(GO:0031762) |
| 0.8 | 19.2 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.8 | 13.4 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.8 | 19.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.8 | 4.7 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.8 | 2.3 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.8 | 17.8 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.8 | 9.2 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.8 | 1.5 | GO:0009008 | DNA-methyltransferase activity(GO:0009008) |
| 0.8 | 3.8 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.7 | 5.9 | GO:0052833 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.7 | 2.9 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.7 | 6.4 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.7 | 0.7 | GO:0097108 | smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108) |
| 0.7 | 2.1 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.7 | 17.5 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.7 | 2.8 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.7 | 2.8 | GO:0004513 | neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291) |
| 0.7 | 2.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) Toll-like receptor 2 binding(GO:0035663) |
| 0.7 | 4.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.6 | 5.8 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.6 | 4.3 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.6 | 4.8 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.6 | 12.0 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.6 | 2.3 | GO:0004077 | biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271) |
| 0.6 | 7.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.6 | 4.5 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.6 | 3.9 | GO:0005113 | patched binding(GO:0005113) |
| 0.5 | 2.2 | GO:0016520 | growth hormone-releasing hormone receptor activity(GO:0016520) |
| 0.5 | 2.2 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.5 | 7.2 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.5 | 2.0 | GO:0004306 | ethanolamine-phosphate cytidylyltransferase activity(GO:0004306) |
| 0.5 | 8.4 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.5 | 1.5 | GO:0008900 | hydrogen:potassium-exchanging ATPase activity(GO:0008900) |
| 0.5 | 3.9 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.5 | 1.9 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.5 | 1.8 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.5 | 16.5 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.5 | 1.8 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.5 | 1.4 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 0.4 | 1.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.4 | 2.2 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.4 | 3.5 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.4 | 1.3 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.4 | 1.7 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
| 0.4 | 0.4 | GO:0086059 | voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059) |
| 0.4 | 2.1 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.4 | 22.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.4 | 15.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.4 | 3.7 | GO:0009374 | biotin binding(GO:0009374) |
| 0.4 | 2.9 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.4 | 11.0 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.4 | 9.5 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.4 | 2.8 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.4 | 2.4 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.4 | 1.9 | GO:0005298 | proline:sodium symporter activity(GO:0005298) |
| 0.4 | 1.2 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.4 | 9.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.4 | 3.4 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.4 | 5.7 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.4 | 6.9 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.4 | 3.0 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.4 | 1.1 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.4 | 4.8 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.4 | 1.5 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.4 | 1.5 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.4 | 1.4 | GO:0003990 | acetylcholinesterase activity(GO:0003990) cholinesterase activity(GO:0004104) |
| 0.4 | 2.1 | GO:0039552 | RIG-I binding(GO:0039552) |
| 0.3 | 6.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.3 | 2.4 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.3 | 5.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.3 | 5.1 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.3 | 1.3 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.3 | 1.3 | GO:0051538 | 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.3 | 1.7 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.3 | 10.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.3 | 1.0 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 0.3 | 1.3 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.3 | 1.6 | GO:0070573 | metallodipeptidase activity(GO:0070573) |
| 0.3 | 3.1 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.3 | 9.1 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.3 | 3.3 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.3 | 3.6 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.3 | 1.8 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.3 | 2.0 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.3 | 0.9 | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089) |
| 0.3 | 6.6 | GO:0031005 | filamin binding(GO:0031005) |
| 0.3 | 1.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.3 | 2.0 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.3 | 4.2 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.3 | 1.7 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.3 | 2.2 | GO:0043996 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.3 | 3.6 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.3 | 8.7 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.3 | 2.8 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.2 | 2.2 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.2 | 3.0 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.2 | 7.9 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.2 | 2.2 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.2 | 7.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.2 | 6.8 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.2 | 18.1 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.2 | 9.8 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.2 | 1.6 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.2 | 4.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.2 | 2.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.2 | 9.7 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.2 | 2.5 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.2 | 2.5 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.2 | 7.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 4.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.2 | 0.9 | GO:1901375 | acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.2 | 0.6 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.2 | 1.0 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.2 | 5.1 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.2 | 5.8 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.2 | 1.2 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.2 | 3.1 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.2 | 0.8 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.2 | 0.8 | GO:0005497 | androgen binding(GO:0005497) |
| 0.2 | 10.5 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.2 | 6.2 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 1.5 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.2 | 3.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 5.5 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.2 | 9.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.2 | 6.6 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.2 | 5.6 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 0.9 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.2 | 3.9 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.2 | 1.1 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.2 | 0.5 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.2 | 6.4 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.2 | 0.7 | GO:0070905 | serine binding(GO:0070905) |
| 0.2 | 12.5 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.2 | 0.7 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) |
| 0.2 | 0.5 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.2 | 1.3 | GO:0008430 | selenium binding(GO:0008430) |
| 0.2 | 4.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 10.8 | GO:0008186 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.1 | 5.3 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 1.2 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
| 0.1 | 3.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 1.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 1.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 0.6 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.1 | 0.7 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 0.7 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 0.1 | 1.1 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 2.0 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.7 | GO:0004803 | transposase activity(GO:0004803) |
| 0.1 | 9.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 10.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 2.4 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 3.4 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.1 | 3.2 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.1 | 4.5 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 5.0 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 1.4 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.1 | 0.8 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 3.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 9.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 2.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 4.7 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 27.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 0.7 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.1 | 1.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 0.3 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.1 | 1.0 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.1 | 0.4 | GO:0022840 | leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842) |
| 0.1 | 1.9 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.1 | 12.3 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 34.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 0.5 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.1 | 3.7 | GO:0008173 | RNA methyltransferase activity(GO:0008173) |
| 0.1 | 1.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 5.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 4.7 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 4.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 1.7 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 3.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 0.4 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 1.9 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.1 | 0.9 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 3.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 1.2 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 1.1 | GO:0016278 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.1 | 2.0 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 0.2 | GO:0047493 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 4.1 | GO:0004521 | endoribonuclease activity(GO:0004521) |
| 0.1 | 1.5 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 3.8 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 0.9 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 4.1 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.1 | 1.3 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 16.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 0.9 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 1.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 1.0 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
| 0.1 | 0.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 1.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.5 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 0.4 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 4.3 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.9 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.0 | 0.8 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 0.7 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 1.1 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.1 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.0 | 3.9 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 1.0 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 1.0 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 1.2 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 0.2 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.0 | 0.3 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.0 | 0.1 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.0 | 0.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.1 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.0 | 1.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.1 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.0 | 0.3 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 1.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.5 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.1 | GO:0046790 | virion binding(GO:0046790) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 95.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 1.1 | 42.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.8 | 43.7 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.6 | 10.8 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.6 | 9.5 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.5 | 3.3 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.5 | 32.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.5 | 29.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.5 | 4.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.4 | 9.4 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.4 | 5.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.4 | 1.9 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.4 | 7.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.3 | 2.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.3 | 6.7 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.3 | 12.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 7.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 17.2 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.3 | 8.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.3 | 20.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 6.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 2.1 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.3 | 14.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 12.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.2 | 2.6 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.2 | 3.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 4.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.2 | 2.6 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.2 | 4.6 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.2 | 6.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.2 | 23.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 9.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 1.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 2.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 1.1 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.2 | 4.0 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.2 | 8.8 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 3.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.2 | 1.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 7.5 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 11.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 1.7 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 3.3 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 2.0 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 7.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 7.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 7.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.7 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 7.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 1.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 2.4 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.1 | 1.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 5.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 2.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 2.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 6.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 1.4 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 1.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 1.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 1.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 1.0 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 0.9 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 2.3 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 3.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.5 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.0 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.9 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 1.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.3 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.1 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 3.4 | REACTOME SIGNALING BY NOTCH3 | Genes involved in Signaling by NOTCH3 |
| 1.5 | 33.9 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 1.4 | 55.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.3 | 42.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 1.3 | 6.5 | REACTOME SIGNALING BY ERBB2 | Genes involved in Signaling by ERBB2 |
| 1.1 | 16.7 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 1.1 | 9.6 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 1.0 | 23.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.9 | 8.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.8 | 9.7 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.8 | 16.1 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.8 | 13.8 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.7 | 11.9 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.7 | 8.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.7 | 14.8 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.7 | 1.3 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.6 | 36.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.6 | 28.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.6 | 10.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.6 | 24.5 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.6 | 1.7 | REACTOME PLATELET AGGREGATION PLUG FORMATION | Genes involved in Platelet Aggregation (Plug Formation) |
| 0.6 | 8.4 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.5 | 20.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.5 | 10.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.5 | 7.7 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.5 | 2.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.4 | 6.6 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.4 | 16.3 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.4 | 8.4 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.4 | 9.8 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 7.1 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.3 | 7.2 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.3 | 3.4 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.3 | 6.4 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.3 | 5.1 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.3 | 13.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 1.7 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.2 | 7.6 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.2 | 7.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 5.1 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.2 | 7.2 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.2 | 14.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 3.1 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.2 | 4.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.2 | 12.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 6.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 0.6 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.2 | 2.7 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 2.6 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.2 | 2.8 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.2 | 4.8 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.2 | 3.6 | REACTOME FRS2 MEDIATED CASCADE | Genes involved in FRS2-mediated cascade |
| 0.2 | 5.1 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 11.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 3.5 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.2 | 2.0 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.2 | 4.2 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.2 | 4.1 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| 0.2 | 3.3 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.2 | 8.7 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.2 | 3.0 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.2 | 1.8 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 4.6 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 2.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 7.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 5.6 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 2.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 1.6 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.1 | 16.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 1.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.2 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 2.9 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.1 | 2.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 4.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 4.7 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 0.9 | REACTOME INFLUENZA LIFE CYCLE | Genes involved in Influenza Life Cycle |
| 0.1 | 2.3 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 0.9 | REACTOME SIGNALING BY SCF KIT | Genes involved in Signaling by SCF-KIT |
| 0.1 | 0.8 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 2.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 1.5 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.8 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 3.8 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 2.7 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 1.4 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 0.5 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 3.1 | REACTOME SIGNALING BY NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.1 | 1.5 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.1 | 0.7 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.1 | 1.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 2.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.3 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 1.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 4.2 | REACTOME GPCR LIGAND BINDING | Genes involved in GPCR ligand binding |
| 0.1 | 1.2 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 1.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.8 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.3 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.0 | 1.1 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 4.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.8 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.0 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.8 | REACTOME PLC BETA MEDIATED EVENTS | Genes involved in PLC beta mediated events |
| 0.0 | 0.3 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 1.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.6 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |