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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EGR1_EGR4
Z-value: 1.15
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Transcription factors associated with EGR1_EGR4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR4 | hg38_v1_chr2_-_73293538_73293701 | 0.37 | 2.8e-08 | Click! |
| EGR1 | hg38_v1_chr5_+_138465472_138465487 | 0.28 | 2.3e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR1_EGR4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_197749855 Show fit | 27.67 |
ENST00000241502.9
|
forty-two-three domain containing 1 |
|
| chr15_+_72118392 Show fit | 23.04 |
ENST00000340912.6
|
SUMO peptidase family member, NEDD8 specific |
|
| chr12_+_76764241 Show fit | 19.88 |
ENST00000550876.1
|
zinc finger DHHC-type palmitoyltransferase 17 |
|
| chr11_-_64745331 Show fit | 18.54 |
ENST00000377489.5
ENST00000354024.7 |
RAS guanyl releasing protein 2 |
|
| chr11_-_73142308 Show fit | 18.17 |
ENST00000409418.9
|
FCH and double SH3 domains 2 |
|
| chr16_-_352714 Show fit | 15.92 |
ENST00000262320.8
|
axin 1 |
|
| chr5_-_131796921 Show fit | 15.85 |
ENST00000307968.11
ENST00000307954.12 |
folliculin interacting protein 1 |
|
| chr5_-_131797030 Show fit | 15.03 |
ENST00000615660.4
|
folliculin interacting protein 1 |
|
| chr1_-_9129085 Show fit | 14.99 |
ENST00000377411.5
|
G protein-coupled receptor 157 |
|
| chr7_-_44325490 Show fit | 14.31 |
ENST00000350811.7
|
calcium/calmodulin dependent protein kinase II beta |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 56.1 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 2.2 | 44.0 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 2.5 | 41.8 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 8.1 | 40.5 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 4.6 | 27.9 | GO:0016926 | protein desumoylation(GO:0016926) |
| 6.4 | 19.3 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.4 | 18.8 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 1.1 | 18.4 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 18.1 | GO:0007601 | visual perception(GO:0007601) |
| 0.4 | 17.9 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 79.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 49.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.6 | 38.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 31.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 31.6 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.3 | 30.4 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.5 | 26.2 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.3 | 25.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.2 | 23.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.4 | 23.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 57.6 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 1.1 | 53.6 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 2.5 | 41.8 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 10.1 | 40.5 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 34.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 4.6 | 27.9 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 2.0 | 27.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 27.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 22.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.9 | 19.7 | GO:0001223 | transcription coactivator binding(GO:0001223) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 95.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.8 | 43.7 | PID REELIN PATHWAY | Reelin signaling pathway |
| 1.1 | 42.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.5 | 32.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.5 | 29.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.2 | 23.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 20.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 17.2 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.3 | 14.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 12.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 55.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.3 | 42.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.6 | 36.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.5 | 33.9 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.6 | 28.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.6 | 24.5 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 1.0 | 23.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.5 | 20.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.1 | 16.7 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 16.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |