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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EGR3_EGR2
Z-value: 0.81
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Transcription factors associated with EGR3_EGR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR3 | hg38_v1_chr8_-_22693469_22693487 | 0.10 | 1.3e-01 | Click! |
| EGR2 | hg38_v1_chr10_-_62816309_62816320, hg38_v1_chr10_-_62816341_62816388 | -0.05 | 4.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR3_EGR2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_124739927 Show fit | 13.29 |
ENST00000284292.11
ENST00000412681.2 |
neurogranin |
|
| chr4_-_25862979 Show fit | 10.88 |
ENST00000399878.8
|
SEL1L family member 3 |
|
| chr11_-_64745331 Show fit | 9.91 |
ENST00000377489.5
ENST00000354024.7 |
RAS guanyl releasing protein 2 |
|
| chr2_+_30231524 Show fit | 8.54 |
ENST00000395323.9
ENST00000406087.5 ENST00000404397.5 |
LBH regulator of WNT signaling pathway |
|
| chr19_+_35143237 Show fit | 7.56 |
ENST00000586063.5
ENST00000270310.7 ENST00000588265.1 |
FXYD domain containing ion transport regulator 7 |
|
| chrX_-_47619850 Show fit | 7.31 |
ENST00000295987.13
ENST00000340666.5 |
synapsin I |
|
| chr5_+_68288346 Show fit | 7.16 |
ENST00000320694.12
|
phosphoinositide-3-kinase regulatory subunit 1 |
|
| chr2_+_190880809 Show fit | 6.48 |
ENST00000320717.8
|
glutaminase |
|
| chr15_+_31326807 Show fit | 6.23 |
ENST00000307145.4
|
Kruppel like factor 13 |
|
| chr14_+_99684283 Show fit | 5.89 |
ENST00000261835.8
|
cytochrome P450 family 46 subfamily A member 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 2.3 | 13.8 | GO:0051621 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 0.3 | 12.3 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.6 | 10.9 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 0.5 | 9.5 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 3.1 | 9.4 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.0 | 9.2 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 1.7 | 8.5 | GO:1904674 | positive regulation of somatic stem cell population maintenance(GO:1904674) regulation of stem cell division(GO:2000035) |
| 1.4 | 8.1 | GO:1900369 | regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) |
| 1.0 | 8.0 | GO:0006013 | mannose metabolic process(GO:0006013) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.4 | 16.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 15.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.6 | 14.2 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.2 | 11.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 11.1 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.2 | 10.9 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 10.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 2.3 | 9.4 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.2 | 9.4 | GO:0097542 | ciliary tip(GO:0097542) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 15.7 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.7 | 15.1 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 1.1 | 14.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 2.3 | 13.8 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.4 | 13.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.2 | 10.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 9.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.0 | 9.4 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.9 | 9.3 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.8 | 8.7 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 18.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 13.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.6 | 12.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 10.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 8.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.2 | 8.4 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.2 | 8.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 7.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 6.7 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 16.3 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.3 | 14.7 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.4 | 14.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 11.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.4 | 11.5 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 10.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 9.7 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.4 | 9.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 8.9 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.3 | 8.2 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |