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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ELF2_GABPA_ELF5
Z-value: 4.88
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Transcription factors associated with ELF2_GABPA_ELF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF2 | hg38_v1_chr4_-_139084289_139084496 | 0.43 | 3.2e-11 | Click! |
| ELF5 | hg38_v1_chr11_-_34513785_34513805 | -0.33 | 7.9e-07 | Click! |
| GABPA | hg38_v1_chr21_+_25734948_25734988 | 0.30 | 5.9e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF2_GABPA_ELF5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.9 | 2690.1 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 15.6 | 2000.6 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 5.6 | 1565.2 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 16.0 | 1150.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 27.2 | 1141.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 11.4 | 914.4 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 24.0 | 673.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 8.5 | 663.3 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 9.3 | 656.9 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 15.3 | 627.1 | GO:0009452 | 7-methylguanosine mRNA capping(GO:0006370) 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 2579.4 | GO:0070062 | extracellular exosome(GO:0070062) |
| 17.8 | 1854.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.7 | 1391.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 7.9 | 1272.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 9.1 | 1115.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 100.7 | 1006.9 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 27.2 | 896.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 63.8 | 766.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 11.7 | 727.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 2.7 | 658.4 | GO:0019866 | organelle inner membrane(GO:0019866) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.5 | 2888.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.4 | 2670.4 | GO:0003723 | RNA binding(GO:0003723) |
| 4.6 | 1704.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 19.7 | 1316.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 44.5 | 1247.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 4.2 | 782.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 15.4 | 725.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 6.5 | 651.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 48.4 | 532.8 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 64.9 | 519.1 | GO:0070990 | snRNP binding(GO:0070990) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.1 | 888.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 6.8 | 857.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 12.8 | 654.9 | PID BARD1 PATHWAY | BARD1 signaling events |
| 7.7 | 581.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 6.9 | 510.2 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 9.5 | 492.3 | PID ATR PATHWAY | ATR signaling pathway |
| 5.1 | 442.8 | PID E2F PATHWAY | E2F transcription factor network |
| 8.4 | 377.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 2.5 | 358.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 5.2 | 352.7 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.0 | 2731.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 34.4 | 2373.8 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 26.7 | 1972.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 14.7 | 1691.7 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 5.9 | 892.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 18.0 | 844.0 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 9.4 | 786.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 10.4 | 585.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 24.9 | 572.1 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 15.9 | 539.5 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |