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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ELF3_EHF
Z-value: 1.51
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Transcription factors associated with ELF3_EHF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF3 | hg38_v1_chr1_+_202010575_202010593 | 0.28 | 3.4e-05 | Click! |
| EHF | hg38_v1_chr11_+_34621065_34621099, hg38_v1_chr11_+_34621109_34621135 | 0.11 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF3_EHF
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.5 | 50.1 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
| 3.0 | 45.1 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) |
| 2.7 | 39.9 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 1.2 | 36.1 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 1.9 | 36.0 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.7 | 35.6 | GO:0021762 | substantia nigra development(GO:0021762) |
| 1.0 | 32.9 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.6 | 32.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 3.5 | 31.4 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 1.1 | 30.5 | GO:0006829 | zinc II ion transport(GO:0006829) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 243.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.5 | 68.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 57.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 48.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 2.8 | 44.5 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.3 | 33.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 30.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 30.0 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 29.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 28.7 | GO:0030424 | axon(GO:0030424) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 291.4 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 9.7 | 48.7 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 1.4 | 39.5 | GO:0071949 | FAD binding(GO:0071949) |
| 0.1 | 37.6 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.2 | 36.1 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.6 | 32.6 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.3 | 29.5 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.2 | 29.3 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.4 | 29.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 2.6 | 28.7 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 47.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.6 | 40.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 34.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 26.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.7 | 26.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.3 | 25.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.4 | 23.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 22.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 20.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 18.6 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 203.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.4 | 26.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 23.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 21.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 21.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.6 | 19.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.3 | 19.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.5 | 19.1 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.6 | 15.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.5 | 15.7 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |