ISMARA results: EMX1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for EMX1

Z-value: 1.18

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Transcription factors associated with EMX1

Gene Symbol	Gene ID	Gene Info
EMX1 Ensembl NCBI GeneCards UniProt	ENSG00000135638.14	EMX1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EMX1	hg38_v1_chr2_+_72917489_72917525, hg38_v1_chr2_+_72916183_72916260	0.53	6.6e-17	Click!

Activity profile of EMX1 motif

Sorted Z-values of EMX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr11_-_111923722 Show fit	58.26	ENST00000527950.5	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr11_-_117877463 Show fit	41.78	ENST00000527717.5	FXYD6 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 6
chr12_-_91153149 Show fit	39.41	ENST00000550758.1	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr11_-_117876719 Show fit	35.69	ENST00000529335.6 ENST00000260282.8	FXYD6 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 6
chr11_-_117876892 Show fit	33.64	ENST00000539526.5	FXYD6 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 6
chr12_-_6124662 Show fit	32.61	ENST00000261405.10	VWF Ensembl NCBI GeneCards UniProt Show fit	von Willebrand factor
chr6_-_169250825 Show fit	25.31	ENST00000676869.1 ENST00000676760.1	THBS2 Ensembl NCBI GeneCards UniProt Show fit	thrombospondin 2
chr5_+_151025343 Show fit	24.00	ENST00000521632.1	GPX3 Ensembl NCBI GeneCards UniProt Show fit	glutathione peroxidase 3
chr12_-_91179355 Show fit	18.49	ENST00000550563.5 ENST00000546370.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr14_+_92323154 Show fit	18.04	ENST00000532405.6 ENST00000676001.1 ENST00000531433.5	SLC24A4 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 24 member 4

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	111.2	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
3.4	58.3	GO:0007021	tubulin complex assembly(GO:0007021)
4.5	57.9	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2	34.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.1	33.1	GO:0098828	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
1.4	32.9	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.3	28.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	25.3	GO:0043547	positive regulation of GTPase activity(GO:0043547)
2.5	25.1	GO:0036371	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
8.0	24.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)

Showing 1 to 10 of 225 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	144.4	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	93.1	GO:0005615	extracellular space(GO:0005615)
0.4	67.2	GO:0031091	platelet alpha granule(GO:0031091)
3.6	58.3	GO:0097512	cardiac myofibril(GO:0097512)
4.5	57.9	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	43.4	GO:0043209	myelin sheath(GO:0043209)
0.6	33.1	GO:0048786	presynaptic active zone(GO:0048786)
0.2	32.2	GO:0001650	fibrillar center(GO:0001650)
0.5	26.4	GO:0031430	M band(GO:0031430)
1.4	21.8	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)

Showing 1 to 10 of 101 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	114.5	GO:0017080	sodium channel regulator activity(GO:0017080)
2.2	66.0	GO:0005212	structural constituent of eye lens(GO:0005212)
0.3	55.5	GO:0051015	actin filament binding(GO:0051015)
0.6	48.6	GO:0050840	extracellular matrix binding(GO:0050840)
1.2	39.9	GO:0019865	immunoglobulin binding(GO:0019865)
0.4	38.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	38.7	GO:0008201	heparin binding(GO:0008201)
0.2	33.6	GO:0044325	ion channel binding(GO:0044325)
0.1	32.8	GO:0005096	GTPase activator activity(GO:0005096)
0.3	31.1	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)

Showing 1 to 10 of 157 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	61.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	35.5	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	34.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	33.0	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	30.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	23.3	PID CMYB PATHWAY	C-MYB transcription factor network
0.3	22.5	PID BMP PATHWAY	BMP receptor signaling
0.3	18.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	14.8	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.2	13.7	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	57.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
2.1	49.8	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.5	38.8	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.2	33.0	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.3	23.0	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.7	21.8	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.1	19.4	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.4	19.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	19.2	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.8	16.8	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle

Showing 1 to 10 of 73 entries

Results for EMX1

Z-value: 1.18

Motif logo

Transcription factors associated with EMX1

Activity-expression correlation:

Activity profile of EMX1 motif

Sorted Z-values of EMX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: