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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EMX2
Z-value: 1.00
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Transcription factors associated with EMX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EMX2 | hg38_v1_chr10_+_117543567_117543658, hg38_v1_chr10_+_117542721_117542754, hg38_v1_chr10_+_117542416_117542445 | 0.23 | 4.8e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EMX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 46.2 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 2.0 | 25.9 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.3 | 25.6 | GO:0007032 | endosome organization(GO:0007032) |
| 3.2 | 22.5 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.4 | 21.7 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.2 | 20.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 18.9 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.7 | 18.0 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.5 | 17.8 | GO:0048665 | neuron fate specification(GO:0048665) |
| 1.7 | 16.8 | GO:0009449 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.0 | 48.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.4 | 21.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 18.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.4 | 18.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.5 | 17.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 1.3 | 14.4 | GO:0043203 | axon hillock(GO:0043203) |
| 1.4 | 12.3 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.5 | 11.2 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 9.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 9.1 | GO:0043197 | dendritic spine(GO:0043197) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 48.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.2 | 40.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 40.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 31.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 4.5 | 26.9 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.5 | 26.2 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 1.1 | 18.0 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.3 | 17.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 1.2 | 16.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.2 | 15.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 13.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 10.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 9.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 9.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 7.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 7.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 6.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 6.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 5.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 47.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 1.3 | 26.9 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.3 | 22.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.8 | 18.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.5 | 18.0 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.5 | 17.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 15.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 13.5 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 12.6 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.3 | 11.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |